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Molecular and Cellular Basis of Regeneration and Tissue Repair

Wound epidermis formation and function in urodele amphibian limb regeneration

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Abstract.

Upon amputation of the urodele limb, the epidermal cells surrounding the amputation plane migrate to heal the wound. The resulting wound epidermis (WE) induces the regeneration process, resulting in blastema formation, cell division, and ultimately repatterning into a new limb. Despite its central role in the initiation of limb regeneration, little is known about how the WE forms. Here we discuss various models of WE formation and the experimental data in support of each. (Part of a Multi-author Review)

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Authors and Affiliations

  1. Department of Molecular, Cellular and Developmental Biology, Yale University, P. O. Box 208103, New Haven, CT, 06520-8103, USA

    L. J. Campbell & C. M. Crews

  2. Department of Pharmacology, Yale University, P. O. Box 208103, New Haven, CT, 06520-8103, USA

    C. M. Crews

  3. Department of Chemistry, Yale University, P. O. Box 208103, New Haven, CT, 06520-8103, USA

    C. M. Crews

Authors
  1. L. J. Campbell
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  2. C. M. Crews
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Correspondence to C. M. Crews.

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Campbell, L.J., Crews, C.M. Molecular and Cellular Basis of Regeneration and Tissue Repair. Cell. Mol. Life Sci. 65, 73–79 (2008). https://doi.org/10.1007/s00018-007-7433-z

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  • DOI: https://doi.org/10.1007/s00018-007-7433-z

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