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SUN-domain and KASH-domain proteins during development, meiosis and disease

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Abstract.

SUN-domain proteins interact directly with KASH-domain proteins to form protein complexes that connect the nucleus to every major cytoskeleton network. SUN-KASH protein complexes are also required for attaching centrosomes to the nuclear periphery and for alignment of homologous chromosomes, their pairing and recombination in meiosis. Other functions that require SUN-domain proteins include the regulation of apoptosis and maturation and survival of the germline. Laminopathic diseases affect the distribution of the SUN-KASH complexes, and mutations in KASH-domain proteins can cause Emery Dreifuss muscular dystrophy and recessive cerebellar ataxia. This review describes our current knowledge of the role of SUN-KASH domain protein complexes during development, meiosis and disease.

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Authors and Affiliations

  1. Department of Genetics, Hebrew University of Jerusalem, Jerusalem, 91904, Israel

    A. Fridkin & Y. Gruenbaum

  2. Department of Chromosome Biology, Max F. Perutz Laboratories University of Vienna, A-1030, Vienna, Austria

    A. Penkner & V. Jantsch

Authors
  1. A. Fridkin
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  2. A. Penkner
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  3. V. Jantsch
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  4. Y. Gruenbaum
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Corresponding authors

Correspondence to V. Jantsch or Y. Gruenbaum.

Additional information

All authors contributed equally to this manuscript.

Received 07 November 2008; received after revision 07 December 2008; accepted 09 December 2008

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Fridkin, A., Penkner, A., Jantsch, V. et al. SUN-domain and KASH-domain proteins during development, meiosis and disease. Cell. Mol. Life Sci. 66, 1518–1533 (2009). https://doi.org/10.1007/s00018-008-8713-y

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  • DOI: https://doi.org/10.1007/s00018-008-8713-y

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