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Insect hemolymph clotting

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Abstract

The clot’s appearance in different large-bodied insects has been described, but until recently, little was known about any insect clot’s molecular makeup, and few experiments could directly test its function. Techniques have been developed in Drosophila (fruit fly) larvae to identify clotting factors that can then be tested for effects on hemostasis, healing, and immunity. This has revealed unanticipated complexity in the hemostatic mechanisms in these larvae. While the clot’s molecular structure is not yet fully understood, progress is being made, and the loss of clotting factors has been shown to cause subtle immune defects. The few similarities between coagulation in different insect species and life stages, and the current state of knowledge about coagulation in insects are discussed.

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Acknowledgments

I am grateful to anonymous reviewers for valuable comments. My work was supported by grants from the Swedish Research Council, the Swedish Animal Welfare Agency, the faculty of Uppsala University, and the Illinois Institute of Technology.

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  1. Department of BCPS, Illinois Institute of Technology, 3101 South Dearborn St., Chicago, IL, 60616, USA

    Mitchell S. Dushay

  2. Department of Comparative Physiology, EBC, Uppsala University, Norbyvägen 18A, 752 36, Uppsala, Sweden

    Mitchell S. Dushay

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Dushay, M.S. Insect hemolymph clotting. Cell. Mol. Life Sci. 66, 2643–2650 (2009). https://doi.org/10.1007/s00018-009-0036-0

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