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Reactive oxygen species-dependent signaling regulates cancer

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Abstract

Historically, it has been assumed that oxidative stress contributes to tumor initiation and progression solely by inducing genomic instability. Recent studies indicate that reactive oxygen species are upregulated in tumors and can lead to aberrant induction of signaling networks that cause tumorigenesis and metastasis. Here we review the role of redox-dependent signaling pathways and transcription factors that regulate tumorigenesis.

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Acknowledgements

This work was supported by NIH Grant R01CA123067-03 as well as the LUNGevity Foundation and a Consortium of Independent Lung Health Organizations convened by the Respiratory Health Association of Metropolitan Chicago to N.S.C.

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  1. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Medical School, Chicago, IL, USA

    Frank Weinberg & Navdeep S. Chandel

  2. Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL, 60611, USA

    Navdeep S. Chandel

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  1. Frank Weinberg
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  2. Navdeep S. Chandel
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Correspondence to Navdeep S. Chandel.

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Weinberg, F., Chandel, N.S. Reactive oxygen species-dependent signaling regulates cancer. Cell. Mol. Life Sci. 66, 3663–3673 (2009). https://doi.org/10.1007/s00018-009-0099-y

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