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The response of human skeletal muscle tissue to hypoxia

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Abstract

Hypoxia refers to environmental or clinical settings that potentially threaten tissue oxygen homeostasis. One unique aspect of skeletal muscle is that, in addition to hypoxia, oxygen balance in this tissue may be further compromised when exercise is superimposed on hypoxia. This review focuses on the cellular and molecular responses of human skeletal muscle to acute and chronic hypoxia, with emphasis on physical exercise and training. Based on published work, it is suggested that hypoxia does not appear to promote angiogenesis or to greatly alter oxidative enzymes in skeletal muscle at rest. Although the HIF-1 pathway in skeletal muscle is still poorly documented, emerging evidence suggests that muscle HIF-1 signaling is only activated to a minor degree by hypoxia. On the other hand, combining hypoxia with exercise appears to improve some aspects of muscle O2 transport and/or metabolism.

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Authors and Affiliations

  1. The Copenhagen Muscle Research Centre, Rigshospitalet Sect. 7652, 2100, Copenhagen, Denmark

    Carsten Lundby

  2. Department of Sport Science, University of Århus, 8200, Århus N, Denmark

    Carsten Lundby

  3. Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain

    Jose A. L. Calbet

  4. Ecole Nationale de Ski et d’Alpinisme, 74401, Chamonix, France

    Paul Robach

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  1. Carsten Lundby
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  2. Jose A. L. Calbet
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  3. Paul Robach
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Correspondence to Carsten Lundby.

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Lundby, C., Calbet, J.A.L. & Robach, P. The response of human skeletal muscle tissue to hypoxia. Cell. Mol. Life Sci. 66, 3615–3623 (2009). https://doi.org/10.1007/s00018-009-0146-8

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  • DOI: https://doi.org/10.1007/s00018-009-0146-8

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