Abstract
The trafficking of macromolecules between the cytoplasm and the nucleus is controlled by the nuclear pore complexes (NPCs) and various transport factors that facilitate the movement of cargos through the NPCs and their accumulation in the target compartment. While their functions in transport are well established, an ever-growing number of observations have also linked components of the nuclear transport machinery to processes that control chromosome segregation during mitosis, including spindle assembly, kinetochore function, and the spindle assembly checkpoint. In this review, we will discuss this evolving area of study and emerging hypotheses that propose key roles for components of the nuclear transport apparatus in mitotic progression.
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Acknowledgments
The authors would like to thank “la Fondation des Treilles” (http://www.les-treilles.com) for organizing the first transport and cell cycle meeting in 2007 at the very time when most of the data and concepts now included in this review were emerging (http://www.les-treilles.com/ssimages/c_2007_09_Doye_Wozniak.html). The authors also wish to acknowledge the following agencies for funding: la Ligue Nationale contre le Cancer (V.D., Equipe Labellisée 2006–2009), the Agence Nationale de la Recherche (to V.D.), Canadian Institutes of Health Research (to R.W.W.), the Alberta Heritage Foundation for Medical Research (to R.W.W.), the Howard Hughes Medical Institute (to R.W.W.), and the National Institutes of Health (to B.B.).
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R. Wozniak, B. Burke, and V. Doye contributed equally to this review.
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Wozniak, R., Burke, B. & Doye, V. Nuclear transport and the mitotic apparatus: an evolving relationship. Cell. Mol. Life Sci. 67, 2215–2230 (2010). https://doi.org/10.1007/s00018-010-0325-7
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DOI: https://doi.org/10.1007/s00018-010-0325-7