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Alternative pathways for MHC class I presentation: a new function for autophagy

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Abstract

The classical view that endogenous antigens are processed by the proteasome and loaded on MHC class I molecules in the endoplasmic reticulum, while exogenous antigens taken up by endocytosis or phagocytosis are degraded and loaded on MHC class II in lysosome-derived organelles, has evolved along with the improvement of our understanding of the cell biology of antigen-presenting cells. In recent years, evidence for alternative presentation pathways has emerged. Exogenous antigens can be processed by the proteasome and loaded on MHC class I through a pathway called cross-presentation. Moreover, endogenous antigens can be targeted to lytic organelles for presentation on MHC class II through autophagy, a highly conserved cellular process of self-eating. Recent evidence indicates that the vacuolar degradation of endogenous antigens is also beneficial for presentation on MHC class I molecules. This review focuses on how various forms of autophagy participate to presentation of these antigens on MHC class I.

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Authors and Affiliations

  1. Département de pathologie et biologie cellulaire, Université de Montréal, Montreal, Canada

    Magali Chemali, Kerstin Radtke, Michel Desjardins & Luc English

  2. Département de microbiologie et immunologie, Université de Montréal, Montreal, Canada

    Michel Desjardins

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  1. Magali Chemali
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  2. Kerstin Radtke
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  3. Michel Desjardins
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  4. Luc English
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Correspondence to Luc English.

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M. Chemali and K. Radtke contributed equally to this work.

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Chemali, M., Radtke, K., Desjardins, M. et al. Alternative pathways for MHC class I presentation: a new function for autophagy. Cell. Mol. Life Sci. 68, 1533–1541 (2011). https://doi.org/10.1007/s00018-011-0660-3

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