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The expanding universe of hypoxia

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Abstract

Reduced oxygen availability (hypoxia) is sensed and transduced into changes in the activity or expression of cellular macromolecules. These responses impact on virtually all areas of biology and medicine. In this meeting report, we summarize major developments in the field that were presented at the 2008 Keystone Symposium on Cellular, Physiological, and Pathogenic Responses to Hypoxia.

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Acknowledgments

We thank our meeting co-organizers, Nanduri Prabhakar and Lorenz Poellinger; the Keystone Symposium; and all of the participants of this meeting. We regret that due to space limitations, we were unable to discuss the large number of truly outstanding workshop and poster presentations. We are also grateful to Mark W. Majesky, Peter M. Carmeliet and Luisa Iruela-Arispe, who were the organizers of the symposium entitled Molecular Mechanisms of Angiogenesis in Development and Disease, which was held concurrently with the Hypoxia symposium. The participants of these two meetings experienced the heartbreaking loss of M. Judah Folkman, the pioneer of angiogenesis research, who passed away while en route to Vancouver where he was to deliver a joint keynote address. The field will forever benefit from Dr. Folkman’s seminal contributions.

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Authors and Affiliations

  1. Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, 733 North Broadway, Suite 671, Baltimore, MD, 21205, USA

    Huafeng Zhang & Gregg L. Semenza

  2. Departments of Pediatrics, Medicine, Oncology, and Radiation Oncology, The Johns Hopkins University School of Medicine, 733 North Broadway, Suite 671, Baltimore, MD, 21205, USA

    Huafeng Zhang & Gregg L. Semenza

  3. McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, 733 North Broadway, Suite 671, Baltimore, MD, 21205, USA

    Huafeng Zhang & Gregg L. Semenza

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  1. Huafeng Zhang
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Correspondence to Gregg L. Semenza.

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Zhang, H., Semenza, G.L. The expanding universe of hypoxia. J Mol Med 86, 739–746 (2008). https://doi.org/10.1007/s00109-008-0364-9

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