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The pneumococcus: why a commensal misbehaves

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Abstract

Several characteristics of Streptococcus pneumoniae (pneumococcus) combine to make it a particularly problematic pathogen. Firstly, the pneumococcus has the capacity to cause disease through the expression of virulence factors such as its polysaccharide capsule and pore-forming toxin. In addition, the pneumococcus is highly adaptable as demonstrated by its ability to acquire and disseminate resistance to multiple antibiotics. Although the pneumococcus is a major cause of disease, the organism is most commonly an “asymptomatic” colonizer of its human host (the carrier state), with transmission occurring exclusively from this reservoir of commensal organisms. Thus, it is unclear how the organism’s virulence and adaptability promote its persistence or host to host spread during its carrier state. This review summarizes current understanding of how these characteristics may contribute to the commensal lifestyle of the pneumococcus.

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Acknowledgments

The author is indebted to the current and former members of his laboratory contributing to these studies. This work was supported by grants from the U.S. Public Health Service (AI44231, AI38446, and AI78538).

Conflict of interest statement

The author declares no conflict of interest.

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Authors and Affiliations

  1. Department of Microbiology and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    Jeffrey N. Weiser

  2. University of Pennsylvania School of Medicine, 402A Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA, 19104-6076, USA

    Jeffrey N. Weiser

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Correspondence to Jeffrey N. Weiser.

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Weiser, J.N. The pneumococcus: why a commensal misbehaves. J Mol Med 88, 97–102 (2010). https://doi.org/10.1007/s00109-009-0557-x

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  • DOI: https://doi.org/10.1007/s00109-009-0557-x

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