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Thioredoxins in bacteria: functions in oxidative stress response and regulation of thioredoxin genes

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Abstract

Thioredoxins fulfill a number of different important cellular functions in all living organisms. In bacteria, thioredoxin genes are often regulated by external factors. In turn, thioredoxins influence the expression of many other genes. The multiple and important functions of thioredoxins in cells necessitate to appropriately adjust their level. This review outlines different strategies that have evolved for the regulation of bacterial thioredoxin genes. It also summarizes effects of thioredoxins on gene regulation and presents a recent model for a redox-dependent gene regulation that is mediated by thioredoxins.

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Acknowledgements

The work from the authors was supported by the Deutsche Forschungsgemeinschaft (Kl563/16), the Fonds der chemischen Industrie, the BMBF, and the DAAD.

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  1. Institut für Mikrobiologie und Molekularbiologie, University of Giessen, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany

    Tanja Zeller & Gabriele Klug

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Correspondence to Gabriele Klug.

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Zeller, T., Klug, G. Thioredoxins in bacteria: functions in oxidative stress response and regulation of thioredoxin genes. Naturwissenschaften 93, 259–266 (2006). https://doi.org/10.1007/s00114-006-0106-1

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