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Measurement of indocyanine green plasma disappearance rate by two different dosages

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Abstract

Objective

While using a transcutaneous system for assessment of liver function by indocyanine green plasma disappearance rate (ICG-PDR) in critically ill patients, we compared the agreement between ICG-PDR obtained by the recommended standard ICG dosage (0.5 mg/kg) and a reduced dosage (0.25 mg/kg).

Design

Clinical study.

Setting

Intensive care unit of a university hospital.

Patients

Critically ill patients (n=16, 5 female, 11 male) who underwent liver function monitoring by ICG-PDR for clinical indication.

Measurements and results

We analyzed 31 pairs of ICG-PDR measurements by applying the recommended dosage (0.5 mg/kg, ICG-PDR0.5) and a reduced dosage (0.25 mg/kg, ICG-PDR0.25). For each comparative measurement either first 0.5 mg/kg or 0.25 mg/kg of ICG was injected in a random fashion and followed by the corresponding dosage 60 min later. All patients were sedated and mechanically ventilated via a tracheal tube. Each patient was monitored by an ICG finger clip which was connected to a liver function monitoring system (LiMon, Pulsion Medical Systems, Germany). ICG-PDR0.25 was 2.7–25.0 %/min and ICG-PDR0.5 4.5–24.5 %/min, respectively. Linear regression analysis revealed ICG-PDR0.25=1.13·ICG-PDR0.5−0.66 %/min (r=0.95, p<0.0001) with a mean bias 1.0 %/min (standard deviation 2.5 %/min). The 15 min residual rates were also highly correlated (r=0.92, p<0.0001) with a mean bias of 0.3%.

Conclusion

A reduced dosage of ICG (0.25 mg/kg) is sufficiently accurate for transcutaneous measurement of ICG-PDR in critically ill patients.

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Authors and Affiliations

  1. Department of Anesthesiology and Intensive Care Medicine, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 , Jena, Germany

    Samir G. Sakka & Heiko Koeck

  2. Department of Anesthesiology and Intensive Care Medicine, HELIOS-Klinikum, Erfurt, Germany

    Andreas Meier-Hellmann

Authors
  1. Samir G. Sakka
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  2. Heiko Koeck
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  3. Andreas Meier-Hellmann
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Corresponding author

Correspondence to Samir G. Sakka.

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Sakka, S.G., Koeck, H. & Meier-Hellmann, A. Measurement of indocyanine green plasma disappearance rate by two different dosages. Intensive Care Med 30, 506–509 (2004). https://doi.org/10.1007/s00134-003-2091-6

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  • DOI: https://doi.org/10.1007/s00134-003-2091-6

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