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Plasmatic cystatin C for the estimation of glomerular filtration rate in intensive care units

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Abstract

Objective

To compare the sensitivity of cystatin C and creatinine in detecting decreased glomerular filtration rate.

Design

Prospective observational study.

Setting

Medical intensive care unit at a university hospital.

Patients and participants

Fourteen patients hospitalised in a medical intensive care unit.

Interventions

Cystatin C and creatinine plasmatic levels were measured in 40 blood samples taken with an interval of at least 24 h.

Measurements and results

Glomerular filtration rate was estimated by creatinine clearance using 24-h urine collection and the classical Cockcroft-Gault equation. The ability of cystatin C to detect a glomerular filtration rate under 80 ml/min per 1.73 m2 was significantly better than that of creatinine (p<0.05).

Conclusions

Cystatin C, a new plasmatic marker of renal function, could be used to detect renal failure in intensive care in the future.

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References

  1. Perrone RD, Madias NE, Levey AS (1992) Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem 38:1933–1953

    CAS  PubMed  Google Scholar 

  2. Randers E, Kristensen JH, Erlandsen EJ, Danielsen H (1998) Serum cystatin C as a marker of the renal function. Scand J Clin Lab Invest 58:585–592

    Article  CAS  PubMed  Google Scholar 

  3. Uchida K, Gotoh A (2002) Measurement of cystatin-C and creatinine in urine. Clin Chim Acta 323:121–128

    Article  CAS  PubMed  Google Scholar 

  4. Mojiminiyi OA, Marouf R, Abdella N, Kortom M, Abdul-Razzak R (2002) Serum concentration of cystatin C is not affected by cellular proliferation in patients with proliferative haematological disorders. Ann Clin Biochem 39:308–310

    Article  CAS  PubMed  Google Scholar 

  5. Randers E, Kornerup K, Erlandsen EJ, Hasling C, Danielsen H (2001) Cystatin C levels in sera of patients with acute infectious diseases with high C-reactive protein levels. Scand J Clin Lab Invest 61:333–335

    Article  CAS  PubMed  Google Scholar 

  6. Vinge E, Lindergard B, Nilsson-Ehle P, Grubb A (1999) Relationships among serum cystatin C, serum creatinine, lean tissue mass and glomerular filtration rate in healthy adults. Scand J Clin Lab Invest 59:587–592

    Article  CAS  PubMed  Google Scholar 

  7. Dharnidharka VR, Kwon C, Stevens G (2002) Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis 40:221–226

    Article  CAS  PubMed  Google Scholar 

  8. Fricker M, Wiesli P, Brandle M, Schwegler B, Schmid C (2003) Impact of thyroid dysfunction on serum cystatin C. Kidney Int 63:1944–1947

    CAS  PubMed  Google Scholar 

  9. Risch L, Huber AR (2002) Glucocorticoids and increased serum cystatin C concentrations. Clin Chim Acta 320:133–134

    Article  CAS  PubMed  Google Scholar 

  10. Finney H, Newman DJ, Gruber W, Merle P, Price CP (1997) Initial evaluation of cystatin C measurement by particle-enhanced immunonephelometry on the Behring nephelometer systems (BNA, BN II). Clin Chem 43:1016–1022

    CAS  PubMed  Google Scholar 

  11. Galteau MM, Guyon M, Gueguen R, Siest G (2001) Determination of serum cystatin C: biological variation and reference values. Clin Chem Lab Med 39:850–857

    CAS  PubMed  Google Scholar 

  12. National Kidney Foundation (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification and stratification. Kidney Disease Outcome Quality Initiative. Am J Kidney Dis 39:S76-S110

    Article  Google Scholar 

  13. Cameron J, Greger R (1998) Renal function and testing of function. In: Davison AM, Grünfeld JP, Cameron JS (eds) Oxford textbook of clinical nephrology. Oxford University Press, Oxford, pp 39–69

  14. Erley CM, Bader BD, Berger ED, Vochazer A, Jorzik JJ, Dietz K, Risler T (2001) Plasma clearance of iodine contrast media as a measure of glomerular filtration rate in critically ill patients. Crit Care Med 29:1544–1550

    Article  CAS  PubMed  Google Scholar 

  15. Wharton WW III, Sondeen JL, McBiles M, Gradwohl SE, Wade CE, Ciceri DP, Lehmann HG, Stotler RE, Henderson TR, Whitaker WR et al. (1992) Measurement of glomerular filtration rate in ICU patients using 99mTc-DTPA and inulin. Kidney Int 42:174–178

    PubMed  Google Scholar 

  16. Zarowitz BJ, Robert S, Peterson EL (1992) Prediction of glomerular filtration rate using aminoglycoside clearance in critically ill medical patients. Ann Pharmacother 26:1205–1210

    CAS  PubMed  Google Scholar 

  17. Sladen RN, Endo E, Harrison T (1987) Two-hour versus 22-hour creatinine clearance in critically ill patients. Anesthesiology 67:1013–1016

    CAS  PubMed  Google Scholar 

  18. Wilson RF, Soullier G (1980) The validity of two-hour creatinine clearance studies in critically ill patients. Crit Care Med 8:281–284

    CAS  PubMed  Google Scholar 

  19. Robert S, Zarowitz BJ, Peterson EL, Dumler F (1993) Predictability of creatinine clearance estimates in critically ill patients. Crit Care Med 21:1487–1495

    CAS  PubMed  Google Scholar 

  20. Ronco C, Bellomo R (2003) Prevention of acute renal failure in the critically ill. Nephron 93:C13-C20

    Article  PubMed  Google Scholar 

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Acknowledgements

We want to thank Miss Emma Jones and Mrs Rosalie Bonmariage for their help in the manuscript redaction.

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Authors and Affiliations

  1. Nephrology, Department of Medicine, Liege University Hospital, CHU Sart Tilman (B35), 4000, Liege, Belgium

    Pierre Delanaye & Georges Rorive

  2. Medical Intensive Care Unit, Department of Medicine, Liege University Hospital, CHU Sart Tilman (B35), 4000, Liege, Belgium

    Bernard Lambermont

  3. Department of Clinical Chemistry, Liege University Hospital, CHU Sart Tilman (B35), 4000, Liege, Belgium

    Jean-Paul Chapelle & Jacques Gielen

  4. Department of Statistics, University of Liege, 4000, Liege, Belgium

    Paul Gerard

Authors
  1. Pierre Delanaye
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  2. Bernard Lambermont
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  3. Jean-Paul Chapelle
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  4. Jacques Gielen
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  5. Paul Gerard
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  6. Georges Rorive
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Corresponding author

Correspondence to Bernard Lambermont.

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Delanaye, P., Lambermont, B., Chapelle, JP. et al. Plasmatic cystatin C for the estimation of glomerular filtration rate in intensive care units. Intensive Care Med 30, 980–983 (2004). https://doi.org/10.1007/s00134-004-2189-5

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  • DOI: https://doi.org/10.1007/s00134-004-2189-5

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