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Angiotensin-converting enzyme D allele does not influence susceptibility to acute hypoxic respiratory failure in children

  • Pediatric Brief Report
  • Published:
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Abstract

Objective

The D allele of the I/D polymorphism in the angiotensin-converting enzyme (ACE) gene has been associated with an increased risk of ARDS in critically ill adults and severity of bronchopulmonary dysplasia in pre-term infants. We hypothesised that the presence of the hypoxia-associated ACE D allele would increase susceptibility to acute hypoxic respiratory failure (AHRF) in a cohort of critically ill children.

Design and setting

Single-centre prospective observational cohort study.

Patients

Children under 16 years of age requiring admission to a tertiary general PICU.

Measurements and results

A total of 216 Caucasian patients were enrolled. Thirty (13.9%) children developed AHRF and 13 were diagnosed with ARDS (6.0%). There was no significant difference in ACE D allele frequency between patient groups with or without AHRF (0.53 vs. 0.54).

Conclusions

Variation in ACE activity does not influence the development of paediatric AHRF. This may reflect a different pathogenesis from adult ARDS.

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Acknowledgments

This work was undertaken at Great Ormond Street Hospital/UCL Institute of Child Health, which received a proportion of funding from the Department of Health’s NIHR Biomedical Research Centres funding scheme. SEH and KL are supported by the British Heart Foundation (PG/2005/014). RA is supported by the Great Ormond Street Hospital Special Trustees.

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Authors and Affiliations

  1. Paediatric Intensive Care Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK

    Adrian Plunkett, Rachel S. Agbeko & Mark J. Peters

  2. Department of Medicine, Centre for Cardiovascular Genetics, University College London, London, UK

    KaWah Li & Steve E. Humphries

  3. Infectious Diseases and Microbiology Unit, Institute of Child Health, London, UK

    Nigel J. Klein

Authors
  1. Adrian Plunkett
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  2. Rachel S. Agbeko
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  3. KaWah Li
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  4. Steve E. Humphries
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  5. Nigel J. Klein
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  6. Mark J. Peters
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Corresponding author

Correspondence to Rachel S. Agbeko.

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Plunkett, A., Agbeko, R.S., Li, K. et al. Angiotensin-converting enzyme D allele does not influence susceptibility to acute hypoxic respiratory failure in children. Intensive Care Med 34, 2279–2283 (2008). https://doi.org/10.1007/s00134-008-1260-z

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  • DOI: https://doi.org/10.1007/s00134-008-1260-z

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