Abstract
Summary
We evaluated the association of bone mineral density (BMD) and osteoarthritis (OA) of the hip in elderly men. We found that elderly men with moderate to severe radiographic hip OA (RHOA) had significantly higher areal BMD (aBMD) and volumetric BMD (vBMD) at both the lumbar spine and hip compared to age similar controls without OA.
Introduction
We evaluated the association of BMD measured by dual energy X-ray absorptiometry (DXA) and quantitative computerized tomography (integral, cortical, and trabecular vBMD) and RHOA in a cohort of elderly men.
Methods
A cross-sectional analysis was conducted within the Study of Osteoporotic Fractures in Men, a prospective cohort study of 5,995 US men age ≥ 65 years. Standing pelvic x-rays were done in 4,024 subjects and scored for prevalent RHOA severity. DXA was done in 3,886 subjects, and aBMD and vBMD associations were compared with RHOA score using linear regression, adjusting for covariates.
Results
Both moderate and severe RHOA groups had significantly higher aBMD at all BMD sites (range, 3.7–10.0% difference; p value 0.0012 and p value < 0.005) compared to the control group with no RHOA. The difference remained strong after adjusting for covariates. While the total hip and lumbar spine cortical vBMD measurements of subjects with moderate or severe RHOA was increased compared to controls, trabecular vBMD was not.
Conclusion
Older men, with both moderate and severe RHOA, had significantly higher aBMD and integral vBMD at the hip and lumbar spine compared to controls without RHOA.
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References
Verbrugge LM, Patrick DL (1995) Seven chronic conditions: their impact on US activity levels and use of medical services. Am J Public Health 85(2):173–182
Felson D, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM et al (2000) Osteoarthritis: new insights. Ann Intern Med 133(8):635–646
Burger H, van Daele PL, Odding E, Valkenburg HA, Hofman A, Grobbee DE et al (1996) Association of radiographically evident osteoarthritis with higher bone mineral density and increased bone loss with age. The Rotterdam Study. Arthritis Rheum 39(1):81–86
Nevitt MC, Lane NE, Scott JC, Hochberg MC, Pressman AR, Genant HK et al (1995) Radiographic osteoarthritis of the hip and bone mineral density. Arthritis Rheum 38:907–916
Bergink AP, Uitterlinden AG, Van Leeuwen JP, Hofman A, Verhaar JA, Pols HA (2005) Bone mineral density and vertebral fracture history are associated with incident and progressive radiographic knee osteoarthritis in elderly men and women: the Rotterdam study. Bone 37:446–456
Hart DJ, Cronin C, Daniels M, Worthy T, Doyle DV, Spector TD (2002) The relationship of bone density and fracture to incident and progressive radiographic osteoarthritis of the knee. Arthritis Rheum 46(1):92–99
Hochberg MC, Lethbridge-Cejku M, Tobin JD (2004) Bone mineral density and osteoarthritis: data from the Baltimore longitudinal study of aging. Osteoarthr Cartil 12(Suppl A):S45–S48
Radin EL, Paul IL, Rose RM (1972) Role of mechanical factors in pathogenesis of primary osteoarthritis. Lancet 1(7749):519–522
Mansell JP, Collins C, Bailey AJ (2007) Bone, not cartilage, should be the major focus in osteoarthritis. Nat Clin Pract Rheumatol 3(6):306–307
Dixon T, Benjamin J, Lund P, Graham A, Krupinski E (2000) Femoral neck buttressing: a radiographic and histologic analysis. Skelet Radiol 29(10):587–592
Reid D (2003) An overview of osteoporosis, Chapter 1. In: New SA, Bonjour JP (eds) Nutritional aspects of bone health. Royal Society of Chemistry, Cambridge UK, pp 1–12
Lang T, Duryea J (2003) Peripheral bone mineral assessment of the axial skeleton, Chapter 4. In: Orwoll E, Bliziotes M (eds) Osteoporosis: pathophysiology and clinical management. Humana Press, New Jersey USA, pp 83–104
Arokoski JP, Arokoski MH, Jurvelin JS, Helminen HJ, Niemitukia LH, Kroger H (2002) Increased bone mineral content and bone size in the femoral neck of men with hip osteoarthritis. Ann Rheum Dis 61(2):145–150
Lane NE, Nevitt MC, Genant HK, Hochberg MC, Scott JC, Pressman AR et al (1993) Reliability of new indices of radiographic osteoarthritis of the hand and hip and lumbar disc degeneration. J Rheumatol 20(11):1911–1918
Lane NE, Nevitt MC, Hochberg MC, Hung YY, Palermo L (2004) Progression of radiographic hip osteoarthritis over eight years in a community sample of elderly white women. Arthritis Rheum 50(5):1360–1365
Croft P, Cooper C, Wickham C, Coggon D (1990) Defining osteoarthritis of the hip for epidemiologic studies. Am J Epidemiol 132(3):514–522
Orwoll ES, Blank JB, Barrett-Connor E, Cauley J, Cummings S, Ensrud K et al (2005) Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study. Contemp Clin Trials 26:569–585
Marshall LM, Lang TF, Lambert LC, Zmuda JM, Ensrud KE, Orwoll ES (2006) Dimensions and volumetric BMD of the proximal femur and their relation to age among older US men. J Bone Miner Res 21(8):1197–1206
Lang T, LeBlanc A, Evans H, Lu Y, Genant H, Yu A (2004) Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight. J Bone Miner Res 19(6):1006–1012
Washburn RA, Smith KW, Jette AM, Janney CA (1993) The physical activity scale for the elderly (PASE): development and evaluation. J Clin Epidemiol 46(2):153–162
Antoniades L, MacGregor AJ, Matson M, Spector TD (2000) A cotwin control study of the relationship between hip osteoarthritis and bone mineral density. Arthritis Rheum 43(7):1450–1455
Zhang Y, Hannan MT, Chaisson CE, McAlindon TE, Evans SR, Aliabadi P et al (2000) Bone mineral density and risk of incident and progressive radiographic knee osteoarthritis in women: the Framingham Study. J Rheumatol 27(4):1032–1037
Nevitt MC, Zhang Y, Javaid MK, Neogi T, Curtis J, McCullough CE, Wang N, Felson DT (2007) Systemic BMD and risk of incident and progressive tibiofemoral radiographic OA in white men and women: the MOST Study. Arthritis Rheum vol. 9, Suppl. 1, Abstract #2062
Lories RJ, Peeters J, Bakker A, Tylzanowski P, Derese I, Schrooten J et al (2007) Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Arthritis Rheum 56(12):4095–4103
Bodine PV, Zhao W, Kharode YP, Bex FJ, Lambert AJ, Goad MB et al (2004) The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Mol Endocrinol 18:1222–1237
Lane NE, Nevitt MC, Lui LY, de Leon P, Corr M (2007) Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women. Arthritis Rheum 56(10):3319–3325
Dell'Accio F, De Bari C, El Tawil NM, Barone F, Mitsiadis TA, O'Dowd J et al (2006) Activation of WNT and BMP signaling in adult human cartilage following mechanical injury. Arthritis Res Ther 8(5):R139
Sandini L, Arokoski JP, Jurvelin JS, Kroger H (2005) Increased bone mineral content but not bone mineral density in the hip in surgically treated knee and hip osteoarthritis. J Rheumatol 32(10):1951–1957
Genant HK, Block JE, Steiger P, Glueer CC, Smith R (1987) Quantitative computed tomography in assessment of osteoporosis. Semin Nucl Med 17(4):316–333
Li B, Aspden RM (1997) Composition and mechanical properties of cancellous bone from the femoral head of patients with osteoporosis or osteoarthritis. J Bone Miner Res 12(4):641–651
Fazzalari NL, Moore RJ, Manthey BA, Vernon-Roberts B (1992) Comparative study of iliac crest and subchondral femoral bone in osteoarthritic patients. Bone 13(4):331–335
Lian KC, Lang TF, Keyak JH, Modin GW, Rehman Q, Do L, Lane NE (2005) Differences in hip quantitative computed tomography (QCT) measurements of bone mineral density and bone strength between glucocorticoid-treated and glucocorticoid-naive postmenopausal women. Osteoporos Int 16(6):642–650
Fazzalari NL, Darracott J, Vernon-Roberts B (1985) Histomorphometric changes in the trabecular structure of a selected stress region in the femur in patients with osteoarthritis and fracture of the femoral neck. Bone 6(3):125–133
Jordan GR, Loveridge N, Bell KL, Power J, Dickson GR, Vedi S et al (2003) Increased femoral neck cancellous bone and connectivity in coxarthrosis (hip osteoarthritis). Bone 32(1):86–95
Chappard C, Peyrin F, Bonnassie A, Lemineur G, Brunet-Imbault B, Lespessailles E et al (2006) Subchondral bone micro-architectural alterations in osteoarthritis: a synchrotron micro-computed tomography study. Osteoarthr Cartil 14(3):215–223
Layton MW, Goldstein SA, Goulet RW, Feldkamp LA, Kubinski DJ, Bole GG (1988) Examination of subchondral bone architecture in experimental osteoarthritis by microscopic computed axial tomography. Arthritis Rheum 31(11):1400–1405
Carlson CS, Loeser RF, Jayo MJ, Weaver DS, Adams MR, Jerome CP (1994) Osteoarthritis in cynomolgus macaques: a primate model of naturally occurring disease. J Orthop Res 12(3):331–339
Poole et al (2008) Thresholds for the measurement of cortical thickness in-vivo using computed tomography (the 100 women study). Calcif Tissue Int 83(1):33–33
Acknowledgements
The Osteoporotic Fractures in Men (MrOS) Study is supported by National Institutes of Health (NIH) funding; the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute on Aging (NIA), the National Center for Research Resources (NCRR), and NIH Roadmap for Medical Research under the following grant numbers: U01 AR45580, U01 AR45614, U01 AR45632, U01 AR45647, U01 AR45654, U01 AR45583, U01 AG18197, U01-AG027810, and UL1 RR024140. The NIH and NIAMS provide funding for the MrOS Hip OA ancillary study “Epidemiology and Genetics of Hip OA in Elderly Men” under grant number R01 AR052000. We would like to acknowledge Chung Wu for his technical assistance in radiology reading.
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Chaganti, R.K., Parimi, N., Lang, T. et al. Bone mineral density and prevalent osteoarthritis of the hip in older men for the Osteoporotic Fractures in Men (MrOS) Study Group. Osteoporos Int 21, 1307–1316 (2010). https://doi.org/10.1007/s00198-009-1105-9
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DOI: https://doi.org/10.1007/s00198-009-1105-9