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Biological matrices for the evaluation of exposure to environmental tobacco smoke during prenatal life and childhood

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Abstract

The measurement of nicotine and its major metabolites cotinine and trans-3´-hydroxicotinine together with other minor metabolites (e.g., cotinine N-oxide, cotinine, and trans-3´-hydroxicotinine glucuronides) in conventional and nonconventional biological matrices has been used as a biomarker to assess the exposure to environmental tobacco smoke during childhood. The determination of these substances in matrices such as amniotic fluid, meconium, and fetal hair accounts for prenatal exposure to cigarette smoking at different stages of pregnancy. Nicotine and its metabolites in cord blood, neonatal urine, and breast milk are useful for determining acute exposure to drugs of abuse in the period immediately before and after delivery. Cotinine measurement in children’s blood and urine and nicotine and cotinine measurements in children’s hair constitute objective indexes of acute and chronic exposure during infancy, respectively. However, for monitoring and categorizing cumulative exposure to environmental tobacco smoke during the entire childhood, including the prenatal period, the assessment of nicotine in teeth has been proposed as a promising noninvasive tool. This article reviews the usefulness of measurement of nicotine and its metabolites in different fetal and pediatric biological matrices in light of noninvasive collection, time window of exposure detection, and finally clinical application in pediatrics.

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Abbreviations

APCI:

atmospheric pressure chemical ionization

ETS:

environmental tobacco smoke

GC:

gas chromatography

HPLC:

high-performance liquid chromatography

LC:

liquid chromatography

MS:

mass spectrometry

MS/MS:

tandem mass spectrometry

NPD:

nitrogen—phosphorus detection

PPHN:

persistent pulmonary hypertension of the newborn

RIA:

radioimmunoassay

SPE:

solid-phase extraction

References

  1. Jha P, Ranson M, Nguyen S, Yach D (2002) Am J Public Health 92:1002–1006

    Google Scholar 

  2. DiFranza J, Aligne C, Weitzman M (2004) Pediatrics 113:1007–1015

    Google Scholar 

  3. Koren G (1995) Curr Opin Pediatr 7:128–131

    CAS  Google Scholar 

  4. Weitzman M, Byrd A, Aligne M (2002) Neurotoxicol Teratol 24:397–406

    CAS  Google Scholar 

  5. Samet JM (1994) Future Child 4(3):94–114

    CAS  Google Scholar 

  6. Wells A, English S, Posner L et al (1998) Am J Public Health 88:1503–1509

    CAS  Google Scholar 

  7. Lozano J, García-Algar O, Vall O, de la Torre R, Scaravelli G, Pichini S (2007) Ther Drug Monit 29(6):711–734

    CAS  Google Scholar 

  8. Franchini M, Caruso C, Perico A, Pacifici R, Monleon T, Garcia-Algar O, Rossi S, Pichini S (2008) Acta Paediatr 97(5):546–550

    Google Scholar 

  9. Bearer C, Emerson RK, O’Riordan MA, Roitman E, Shackleton C (1997) Environ Health Perspect 105:202–206

    CAS  Google Scholar 

  10. Chazeron I, Daval S, Ughetto S, Richard D, Nicolay A, Lemery D, Llorca PM, Coudoré F (2008) Pulm Pharmacol Ther 21(3):485–488

    Google Scholar 

  11. Perkins SL, Belcher JM, Livesey JF (1997) Can J Public Health 88(4):232–237

    CAS  Google Scholar 

  12. Perkins SL, Livesey JF, Escares EA, Belcher JM, Dudley DK (1991) Clin Chem 37(11):1989–1993

    CAS  Google Scholar 

  13. Nafstad P, Kongerud J, Botten G, Urdal P, Silsand T, Pedersen BS, Jaakkola JJ (1996) Acta Obstet Gynecol Scand 75(10):902–907

    CAS  Google Scholar 

  14. Puig C, Garcia-Algar O, Monleon T, Pacifici R, Zuccaro P, Sunyer J, Figueroa C, Pichini S, Vall O (2008) BMC Public Health 8:47

    Google Scholar 

  15. Pichini S, Basagaña XB, Pacifici R, Garcia O, Puig C, Vall O, Harris J, Zuccaro P, Segura J, Sunyer J (2000) Environ Health Perspect 108(11):1079–1083

    CAS  Google Scholar 

  16. Chiu HT, Wu HDI, Kuo HW (2008) Sci Total Environ 406(1–2):331–336

    CAS  Google Scholar 

  17. Florek E, Breborowicz GH, Lechowicz W, Wachowiak A, Basior A, Wolna M, Hubert A, Seńczuk M (2006) Przegl Lek 63(10):900–906

    Google Scholar 

  18. Wu FY, Chiu HT, Wu HD, Lin CJ, Lai JS, Kuo HW (2008) Paediatr Perinat Epidemiol 22(3):296–301

    Google Scholar 

  19. Kuo HW, Yang JS, Chiu MC (2002) J Chromatogr B Anal Technol Biomed Life Sci 768(2):297–303

    CAS  Google Scholar 

  20. Mansi G, Raimondi F, Pichini S, Capasso L, Sarno M, Zuccaro P, Pacifici R, Garcia-Algar O, Romano A, Paludetto R (2007) Pediatr Res 61(2):257–261

    CAS  Google Scholar 

  21. Dahlström A, Lundell B, Curvall M, Thapper L (1990) Acta Paediatr Scand 79(2):142–147

    Google Scholar 

  22. Curvall M, Kazemi-Vala E, Enzell CR (1982) J Chromatogr 232:283–293

    CAS  Google Scholar 

  23. Van Vunakis H, Gijka HB, Langone JJ (1993) IARC Sci Publ 109:293–299

    Google Scholar 

  24. Köhler E, Bretschneider D, Rabsilber A, Weise W, Jorch G (2001) Hum Exp Toxicol 20(1):1–7

    Google Scholar 

  25. Zahlsen K, Nilsen OG (1994) Pharmacol Toxicol 75(3–4):143–149

    CAS  Google Scholar 

  26. Kintz P, Villain M, Cirimele V (2006) Ther Drug Monit 28(3):442–446

    CAS  Google Scholar 

  27. Kintz P, Kieffer I, Messer J, Mangin P (1993) J Forensic Sci 38(1):119–123

    CAS  Google Scholar 

  28. Kintz P, Mangin P (1993) Forensic Sci Int 63(1–3):99–104

    CAS  Google Scholar 

  29. Kintz P, Mangin P (1993) J Forensic Sci Soc 33(3):139–142

    CAS  Google Scholar 

  30. Nakahara Y (1999) J Chromatogr B Biomed Sci Appl 733(1–2):161–180

    CAS  Google Scholar 

  31. Eliopoulos C, Klein J, Phan MK, Knie B, Greenwald M, Chitayat D, Koren G (1994) JAMA 271(8):621–623

    CAS  Google Scholar 

  32. Eliopoulos C, Klein J, Chitayat D, Greenwald M, Koren G (1996) Clin Invest Med 19(4):231–242

    CAS  Google Scholar 

  33. Klein J, Koren G (1999) Hum Exp Toxicol 18(4):279–282

    CAS  Google Scholar 

  34. Jacqz-Aigrain E, Zhang D, Maillard G, Luton D, André J, Oury JF (2002) BJOG 109(8):909–911

    CAS  Google Scholar 

  35. Ryu HJ, Seong MW, Nam MH, Kong SY, Lee DH (2006) Rapid Commun Mass Spectrom 20(18):2781–2782

    CAS  Google Scholar 

  36. Seong MW, Hwang JH, Moon JS, Ryu HJ, Kong SY, Um TH, Park JG, Lee DH (2008) Am J Epidemiol 168(10):1140–1144

    Google Scholar 

  37. Palmeri A, Pichini S, Pacifici R, Zuccaro P, Lopez A (2000) Clin Pharmacokinet 38(2):95–110

    CAS  Google Scholar 

  38. Mari F, Politi L, Bertol E (2008) Forensic Sci Int 179(2–3):176–80

    CAS  Google Scholar 

  39. Langman J (1990) Langman’s medical embryology. Williams & Wilkins, Philadelphia, pp 106–123

    Google Scholar 

  40. Pichini S, Altieri I, Zuccaro P, Pacifici R (1996) Clin Pharmacokinet 130:211–228

    Google Scholar 

  41. Szeto HH (1993) Clin Obstet Gynecol 36:246–254

    CAS  Google Scholar 

  42. Pacifici CM, Nottoli R (1995) Clin Pharmacokinet 28:235–269

    CAS  Google Scholar 

  43. Karmowski A, Sobiech KA, Dobek D, Terpiłowski L, Pałczyński B, Miś-Michałek M (1998) Ginekol Pol 69(3):115–122

    CAS  Google Scholar 

  44. Dobek D, Karmowski A, Sobiech KA, Terpiłowski L, Miś-Michałek M (1998) Arch Immunol Ther Exp 46(1):59–61

    CAS  Google Scholar 

  45. Luck W, Nau H, Hansen R, Steldinger R (1985) Dev Pharmacol Ther 8(6):384–95

    CAS  Google Scholar 

  46. Jordanov JS (1990) Eur J Pediatr 149(10):734–737

    CAS  Google Scholar 

  47. Jauniaux E, Gulbis B, Acharya G, Thiry P, Rodeck C (1999) Obstet Gynecol 93(1):25–29

    CAS  Google Scholar 

  48. Ostrea EM Jr, Knapp DK, Romero A, Montes M, Ostrea AR (1994) J Pediatr 124(3):471–476

    CAS  Google Scholar 

  49. Dempsey D, Moore C, Deitermann D, Lewis D, Feeley B, Niedbala RS (1999) Forensic Sci Int 102(2–3):167–171

    CAS  Google Scholar 

  50. Derauf C, Katz AR, Easa D (2003) Am J Epidemiol 158(7):705–709

    Google Scholar 

  51. Sherif NA, Kamel SM, Al-Ashkar OS, Sharaki OA, Seif EA, Hegazy EA (2004) East Mediterr Health J 10(1–2):96–105

    CAS  Google Scholar 

  52. Baranowski J, Pochopie G, Baranowska I (1998) J Chromatogr B Biomed Sci Appl 707(1–2):317–321

    CAS  Google Scholar 

  53. Köhler E, Avenarius S, Rabsilber A, Gerloff C, Jorch C (2007) Hum Exp Toxicol 26(6):535–544

    Google Scholar 

  54. Gray TR, Shakleya DM, Huestis MA (2008) J Chromatogr B Anal Technol Biomed Life Sci 863(1):107–114

    CAS  Google Scholar 

  55. Gray TR, Magri R, Shakleya DM, Huestis MA (2008) Clin Chem 54(12):2018–2027

    CAS  Google Scholar 

  56. Atkinson HC, Begg EJ, Darlow BA (1988) Clin Pharmacokinet 14(4):217–240

    CAS  Google Scholar 

  57. Steldinger R (1988) J Perinat Med 16(3):261–262

    CAS  Google Scholar 

  58. Ferguson B, Wilson DJ, Schaffner W (1976) Am J Dis Child 130(8):837–839

    CAS  Google Scholar 

  59. Luck W, Nau H (1984) Br J Clin Pharmacol 18(1):9–15

    CAS  Google Scholar 

  60. Schwartz-Bickenbach D, Schulte-Hobein B, Abt S, Plum C, Nau H (1987) Toxicol Lett 35(1):73–81

    CAS  Google Scholar 

  61. Becker AB, Manfreda J, Ferguson AC, Dimich-Ward H, Watson WT, Chan-Yeung M (1999) Arch Pediatr Adolesc Med 153(7):689–91

    CAS  Google Scholar 

  62. Schulte-Hobein B, Schwartz-Bickenbach D, Abt S, Plum C, Nau H (1992) Acta Paediatr 81(6–7):550–557

    CAS  Google Scholar 

  63. Dickson PH, Lind A, Studts P, Nipper HC, Makoid M, Therkildsen D (1994) J Forensic Sci 39(1):207–214

    CAS  Google Scholar 

  64. Page-Sharp M, Hale TW, Hackett LP, Kristensen JH, Ilett KF (2003) J Chromatogr B Anal Technol Biomed Life Sci 796(1):173–180

    CAS  Google Scholar 

  65. Ilett KF, Hale TW, Page-Sharp M, Kristensen JH, Kohan R, Hackett LP (2003) Clin Pharmacol Ther 74(6):516–524

    CAS  Google Scholar 

  66. Dahlström A, Ebersjö C, Lundell B (2004) Acta Paediatr 93(6):810–816

    Google Scholar 

  67. Aresta A, Palmisano F, Zambonin CG (2005) Food Chem 93(1):177–181

    CAS  Google Scholar 

  68. Pellegrini M, Marchei E, Rossi S, Vagnarelli F, Durgbanshi A, García-Algar O, Vall O, Pichini S (2007) Rapid Commun Mass Spectrom 21(16):2693–2703

    CAS  Google Scholar 

  69. Vagnarelli F, Amarri S, Scaravelli G, Pellegrini M, Garcia-Algar O, Pichini S (2006) Ther Drug Monit 28(5):585–588

    CAS  Google Scholar 

  70. Dahlström A, Ebersjö C, Lundell B (2008) Acta Paediatr 97(8):1075–1079

    Google Scholar 

  71. Kataoka H, Inoue R, Yagi K, Saito K (2009) J Pharm Biomed Anal 49(1):108–114

    CAS  Google Scholar 

  72. Man CN, Gam LH, Ismail S, Lajis R, Awang R (2006) J Chromatogr B Anal Technol Biomed Life Sci 844(2):322–327

    CAS  Google Scholar 

  73. Florescu A, Ferrence R, Einarson T, Selby P, Soldin O, Koren G (2009) Ther Drug Monit 31(1):14–30

    CAS  Google Scholar 

  74. Rop PP, Grimaldi F, Oddoze C, Viala A (1993) J Chromatogr 612:302–309

    CAS  Google Scholar 

  75. Nafstad P, Botten G, Hagen JA, Zahlsen K, Nilsen OG, Silsand T, Kongerud J (1995) Int J Epidemiol 24(1):88–94

    CAS  Google Scholar 

  76. Leong JW, Dore ND, Shelley K, Holt EJ, Laing IA, Palmer LJ, LeSouef PN (1998) Pulm Pharmacol Ther 11(4):287–290

    CAS  Google Scholar 

  77. Haufroid V, Lison D (1998) Int Arch Occup Environ Health 71(3):162–168

    CAS  Google Scholar 

  78. Heinrich-Ramm R, Wegner R, Garde AH, Baur X (2002) Int J Hyg Environ Health 205(6):493–499

    CAS  Google Scholar 

  79. Feyerabend C, Bryant AE, Jarvis MJ, Russell MA (1986) J Pharm Pharmacol 38(12):917–919

    CAS  Google Scholar 

  80. Langone JJ, Cook G, Bjercke RJ, Lifschitz MH (1988) J Immunol Methods 114(1–2):73–78

    CAS  Google Scholar 

  81. Langone JJ, Gijka HB, Van Vunakis H (1973) Biochemistry 12:500–530

    Google Scholar 

  82. Peterson EL, Johnson CC, Ownby DR (1997) J Clin Epidemiol 50(8):917–923

    CAS  Google Scholar 

  83. Henderson FW, Reid HF, Morris R, Wang OL, Hu PC, Helms RW, Forehand L, Mumford J, Lewtas J, Haley NJ (1989) Am Rev Respir Dis 140:197–201

    CAS  Google Scholar 

  84. Hariharan M, Van Noord T (1991) Clin Chem 37:1276–1280

    CAS  Google Scholar 

  85. Zuccaro P, Altieri I, Rosa M, Passa AR, Pichini S, Pacifici R (1995) J Chromatogr 668:187–188

    CAS  Google Scholar 

  86. Köhler E, Sollich V, Schuster R, Thal W (1999) Hum Exp Toxicol 18:212–217

    Google Scholar 

  87. Bazylak G, Brózik H, Sabanty W (2000) J Pharm Biomed Anal 24(1):113–123

    CAS  Google Scholar 

  88. James H, Tizabi Y, Taylor R (1998) J Chromatogr B Biomed Sci Appl 708(1–2):87–93

    CAS  Google Scholar 

  89. Stepans MB, Fuller SG (1999) Clin Nurs Res 8(3):198–218

    CAS  Google Scholar 

  90. Greenberg RA, Haley NJ, Etzel RA, Loda FA (1984) N Engl J Med 310(17):1075–1078

    CAS  Google Scholar 

  91. Matt GE, Quintana PJ, Hovell MF, Bernert JT, Song S, Novianti N, Juarez T, Floro J, Gehrman C, Garcia M, Larson S (2004) Tob Control 13(1):29–37

    CAS  Google Scholar 

  92. Bernert JT Jr, Turner WE, Pirkle JL, Sosnoff CS, Akins JR, Waldrep MK, Ann Q, Covey TR, Whitfield WE (1997) Clin Chem 43:2281–2291

    CAS  Google Scholar 

  93. Matt GE, Quintana PJ, Liles S, Hovell MF, Zakarian JM, Jacob P 3rd, Benowitz NL (2006) Biomarkers 11(6):507–523

    CAS  Google Scholar 

  94. Boyaci H, Etiler N, Duman C, Basyigit I, Pala A (2006) Pediatr Int 48:382–389

    CAS  Google Scholar 

  95. Joseph DV, Jackson JA, Westaway J, Taub NA, Petersen SA, Wailoo MP (2007) Arch Dis Child Fetal Neonatal 92(6):F484–488

    CAS  Google Scholar 

  96. Anuntaseree W, Mo-Suwan L, Ovatlarnporn C, Tantana C, Ma-a-Lee A (2008) Bull Environ Contam Toxicol 80(1):34–37

    CAS  Google Scholar 

  97. Ceppa F, El Jahiri Y, Mayaudon H, Dupuy O, Burnat P (2000) J Chromatogr 746:115–122

    CAS  Google Scholar 

  98. Luck W, Nau H (1987) Eur J Pediatr 146(1):21–26

    CAS  Google Scholar 

  99. Cone EJ (1993) Ann N Y Acad 694:91–127

    CAS  Google Scholar 

  100. Coultas DB, Howard CA, Peake GT, Skipper BJ (1987) Am Rev Respir Dis 136:305–309

    CAS  Google Scholar 

  101. Ronchetti R, Bonci E, de Castro G, Signoretti F, Macrì F, Ciofetta GC, Villa MP, Indinnimeo L, Martinez FD (1994) Eur Respir J 7(3):472–476

    CAS  Google Scholar 

  102. Jarvis MJ, Russell MA, Feyerabend C, Eiser JR, Morgan M, Gammage P, Gray EM (1985) Br Med J 291(6500):927–929

    CAS  Google Scholar 

  103. Feyerabend C, Russell MAH (1990) J Pharm Pharmacol 42:450–452

    CAS  Google Scholar 

  104. de Suárez López Vergara RG, Galván-Fernández C, Oliva-Hernández C, Domenech Martínez E, Barroso Guerrero F (1999) Rev Clin Esp 199(6):362–365

    Google Scholar 

  105. McAdams SA, Cordeiro ML (1993) J Chromatogr 615(1):148–153

    CAS  Google Scholar 

  106. Bentley MC, Abrar M, Kelk M, Cook J, Phillips K (1999) J Chromatogr B 723:185–194

    CAS  Google Scholar 

  107. Florescu A, Ferrence R, Einarson TR, Selby P, Kramer M, Woodruff S, Grossman L, Rankin A, Jacqz-Aigrain E, Koren G (2007) Ther Drug Monit 29(4):437–446

    CAS  Google Scholar 

  108. Pichini S, Altieri I, Pellegrini M, Pacifici R, Zuccaro P (1997) Forensic Sci Int 84(1–3):243–252

    CAS  Google Scholar 

  109. Nafstad P, Jaakkola JJ, Hagen JA, Zahlsen K, Magnus P (1997) J Expo Anal Environ Epidemiol 7(2):235–239

    CAS  Google Scholar 

  110. Al-Delaimy WK, Crane J, Woodward A (2000) J Expo Anal Environ Epidemiol 10(4):378–384

    CAS  Google Scholar 

  111. Al-Delaimy WK, Crane J, Woodward A (2001) Arch Environ Health 56(2):117–122

    Article  CAS  Google Scholar 

  112. Wood T, Wewers ME, Groner J, Ahijevych K (2004) Nicotine Tob Res 6(5):853–862

    CAS  Google Scholar 

  113. Al-Delaimy WK, Crane J, Woodward A (2002) J Epidemiol Community Health 56(1):66–71

    CAS  Google Scholar 

  114. Knight JM, Eliopoulos C, Klein J, Greenwald M, Koren G (1998) J Asthma 35(1):113–117

    CAS  Google Scholar 

  115. Spanier AJ, Hornung R, Lierl M, Lanphear BP (2006) J Pediatr 149(2):220–226

    CAS  Google Scholar 

  116. Conway TL, Woodruff SI, Edwards CC, Hovell MF, Klein J (2004) Tob Control 13:90–92

    CAS  Google Scholar 

  117. Woodruff SI, Conway TL, Elder JP, Hovell MF (2007) Am J Health Promot 22(2):93–97

    Google Scholar 

  118. Woodruff SI, Conway TL, Edwards CC, Hovell MF (2003) Nicotine Tob Res 5(3):375–385

    CAS  Google Scholar 

  119. Wilson SE, Kahn RS, Khoury J, Lanphear BP (2005) Environ Health Perspect 113(3):362–367

    Article  Google Scholar 

  120. Wilson SE, Kahn RS, Khoury J, Lanphear BP (2007) Chest 131(3):856–862

    CAS  Google Scholar 

  121. Groner JA, Hoshaw-Woodard S, Koren G, Klein J, Castile R (2005) Arch Pediatr Adolesc Med 159(5):450–455

    Google Scholar 

  122. Haustein KO (1994) Int J Clin Pharmacol Ther 32(9):483–487

    CAS  Google Scholar 

  123. Pascual JA, Diaz D, Segura J, Garcia-Algar O, Vall O, Zuccaro P, Pacifici R, Pichini S (2003) Rapid Commun Mass Spectrom 17:2853–2855

    Google Scholar 

  124. Garcia-Algar O, Vall O, Segura J, Pascual JA, Diaz D, Mutnoz L, Zuccaro P, Pacifici R, Pichini S (2003) JAMA 290(2):196–197

    Google Scholar 

  125. Marchei E, Joya X, Garcia-Algar O, Vall O, Pacifici R, Pichini S (2008) Rapid Commun Mass Spectrom 22:2609–2612

    CAS  Google Scholar 

  126. Gray T, Huestis M (2007) Anal Bioanal Chem 388:1455–1465

    CAS  Google Scholar 

  127. Kintz P (1992) J Chromatogr 580(1–2):347–353

    CAS  Google Scholar 

  128. Mahoney GN, Al-Delaimy W (2001) J Chromatogr B Biomed Sci Appl 753(2):179–187

    CAS  Google Scholar 

  129. Sorensen M, Bisgaard H, Stage M, Loft S (2007) Biomarkers 12(1):38–46

    CAS  Google Scholar 

  130. Maziak W, Ali RA, Fouad MF, Rastam S, Wipfli H, Travers MJ, Ward KD, Eissenberg T (2008) Inhal Toxicol 20:17–24

    CAS  Google Scholar 

  131. Wipfli H, Avila-Tang E, Navas-Acien A, Kim S, Onicescu G, Yuan J, Breysse P, Samet JM (2008) Am J Public Health 98(4):672–679

    Google Scholar 

  132. Hegstad S, Khiabani HZ, Kristoffersen L, Kunøe N, Lobmaier PP, Christophersen AS (2008) J Anal Toxicol 32(5):364–372

    CAS  Google Scholar 

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Authors and Affiliations

  1. Unitat de Recerca Infancia i Entorn, IMIM-Hospital del Mar, Pg. Maritim 25–29, 08003, Barcelona, Spain

    Heura Llaquet, Xavier Joya, Esther Papaseit, Oriol Vall & Oscar Garcia-Algar

  2. Departament de Pediatria, Universitat Autònoma Barcelona, Barcelona, Spain

    Heura Llaquet, Xavier Joya, Esther Papaseit, Oriol Vall & Oscar Garcia-Algar

  3. Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Rome, Italy

    Simona Pichini

  4. Drug Testing Consultants, Toronto, Canada

    Julia Klein

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  1. Heura Llaquet
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  2. Simona Pichini
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  3. Xavier Joya
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  4. Esther Papaseit
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  5. Oriol Vall
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  7. Oscar Garcia-Algar
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Correspondence to Oscar Garcia-Algar.

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Llaquet, H., Pichini, S., Joya, X. et al. Biological matrices for the evaluation of exposure to environmental tobacco smoke during prenatal life and childhood. Anal Bioanal Chem 396, 379–399 (2010). https://doi.org/10.1007/s00216-009-2831-8

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