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Effect of X-Ray Irradiation on Proliferation and Differentiation of Osteoblast

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We exposed the osteoblast-like cell line, MC3T3-E1, to 1-to 10-Gy X-ray. Irradiation at doses of 5-Gy dose or more decreased the DNA content of cells at the proliferation stage, confluence, and post-proliferation stages. The alkaline phosphatase activity, conversely, was increased by irradiation, and the calcium content of irradiated cells was greater than that of nonirradiated. These findings suggest that irradiation induces terminal differentiation and calcification of osteoblasts.

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Received: 13 January 1996 / Accepted: 29 May 1996

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Matsumura, S., Jikko, A., Hiranuma, H. et al. Effect of X-Ray Irradiation on Proliferation and Differentiation of Osteoblast. Calcif Tissue Int 59, 307–308 (1996). https://doi.org/10.1007/s002239900129

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  • DOI: https://doi.org/10.1007/s002239900129

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