Skip to main content
SpringerLink
Log in

Clinical evaluation of IDAS II, a new electronic device enabling drug adherence monitoring

  • Pharmacoepidemiology and Prescription
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Abstract

Objective

The goal of this study was to evaluate clinically the acceptability of the IDAS II (Intelligent Drug Administration System), a new electronic device that enables drug adherence monitoring.

Methods

IDAS II was compared to another electronic monitor, the Medication Event Monitoring System (MEMS) in a randomised two-way cross-over study involving 24 hypertensive patients treated with irbesartan. Patients used each device for 2 months. The main parameter of evaluation was the patients’ opinion on both devices. Rates of adherence and blood pressure were also assessed.

Results

Most patients considered both devices to be reliable reminders (IDAS II: 75%;MEMS: 84%, p = ns). Ten patients (42%) preferred the MEMS, while 11 (46%) preferred the IDAS II; three (12%) expressed no preference. Patients found the MEMS device easier to use than the IDAS device (p < 0.001) but appreciated the IDAS blister packs better than the MEMS bulk packaging (p < 0.01). Over the 4-month period, the median “taking adherence” was excellent (99.2%) and comparable with both devices. However, the regularity of drug intake timing was higher with the IDAS II (p < 0.01).

Conclusion

IDAS II, a new electronic device enabling drug adherence monitoring without reconditioning of the drugs appears to be a well-accepted device. Overall, practicability and acceptability of the IDAS II and the MEMS device were similar. Thus, IDAS II could be a useful tool for the management of long-term therapies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Andrade SE, Kahler KH, Frech F, Chan KA (2006) Methods for evaluation of medication adherence and persistence using automated databases. Pharmacoepidemiol Drug Saf 15:565–574

    Article  PubMed  Google Scholar 

  2. Bertholet N, Favrat B, Fallab-Stubi CL, Brunner HR, Burnier M (2000) Why Objective Monitoring of Compliance is Important in the Management of Hypertension. J Clin Hypertens 2:258–262

    Google Scholar 

  3. Burnier M, Santschi V, Favrat B, Brunner HR (2003) Monitoring compliance in resistant hypertension: an important step in patient management. J Hypertens [Suppl] 21:S37–S42

    Article  PubMed  CAS  Google Scholar 

  4. Burnier M, Schneider MP, Chiolero A, Stubi CL, Brunner HR (2001) Electronic compliance monitoring in resistant hypertension: the basis for rational therapeutic decisions. J Hypertens 19:335–341

    Article  PubMed  CAS  Google Scholar 

  5. Caro JJ, Speckman JL, Salas M, Raggio G, Jackson JD (1999) Effect of initial drug choice on persistence with antihypertensive therapy: the importance of actual practice data. Can Med Assoc J 160:41–46

    CAS  Google Scholar 

  6. Cramer JA, Mattson RH, Prevey ML, Scheyer RD, Ouellette VL (1989) How often is medication taken as prescribed? A novel assessment technique. JAMA 261:3273–3277

    Article  PubMed  CAS  Google Scholar 

  7. DiMatteo MR (2004) Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. Med Care 42:200–209

    Article  PubMed  Google Scholar 

  8. Fallab-Stubi CL, Zellweger JP, Sauty A, Uldry C, Iorillo D, Burnier M (1998) Electronic monitoring of adherence to treatment in the preventive chemotherapy of tuberculosis. Int J Tuberc Lung Dis 2:525–530

    PubMed  CAS  Google Scholar 

  9. Haynes RB, McDonald HP, Garg AX (2002) Helping patients follow prescribed treatment: clinical applications. JAMA 288:2880–2883

    Article  PubMed  Google Scholar 

  10. Inui TS, Carter WB, Pecoraro RE (1981) Screening for noncompliance among patients with hypertension: is self-report the best available measure? Med Care 19:1061–1064

    Article  PubMed  CAS  Google Scholar 

  11. Jones JK, Gorkin L, Lian JF, Staffa JA, Fletcher AP (1995) Discontinuation of and changes in treatment after start of new courses of antihypertensive drugs: a study of a United Kingdom population. Br Med J 311:293–295

    CAS  Google Scholar 

  12. Schneider MP, Despland PA, Buclin T, Burnier M (2003) Evaluation of online telemonitoring of drug adherence: a pilot randomised, controlled study in patients with epilepsy. J Inf Technol Healthcare 1:419–435

    Google Scholar 

  13. Urquhart J (1997) The electronic medication event monitor. Lessons for pharmacotherapy. Clin Pharmacokinet 32:345–356

    Article  PubMed  CAS  Google Scholar 

  14. World Health Organization (2003) Adherence to Long Term Therapies:eEvidence for Action. World Health Organization, Geneva, pp 1–194

Download references

Acknowledgements

Funding: This study was supported by a grant from Bang and Olufsen Medicom a/s, Denmark

Conflict of Interest Statement

The authors do not have any conflict of interest. The paper has been written and data analysed independently of BO Medicom, Denmark. There is no financial conflict of interest behind the fact that the study was sponsored by BO Medicom, Denmark.

Author information

Authors and Affiliations

  1. Policlinique Médicale Universitaire, Lausanne, Switzerland

    Valérie Santschi, Marie-Paule Schneider, Olivier Bugnon & Michel Burnier

  2. Division of Nephrology and Hypertension Consultation, Centre Hospitalier Universitaire Vaudois (CHUV), Rue du Bugnon 17, 1011, Lausanne, Switzerland

    Grégoire Wuerzner & Michel Burnier

Authors
  1. Valérie Santschi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Grégoire Wuerzner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marie-Paule Schneider
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Olivier Bugnon
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Michel Burnier
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michel Burnier.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Santschi, V., Wuerzner, G., Schneider, MP. et al. Clinical evaluation of IDAS II, a new electronic device enabling drug adherence monitoring. Eur J Clin Pharmacol 63, 1179–1184 (2007). https://doi.org/10.1007/s00228-007-0364-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00228-007-0364-7

Keywords

Search

Navigation