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The 223A>G polymorphism of the leptin receptor gene and lipid-lowering efficacy of simvastatin in Chinese patients with coronary heart disease

  • Pharmacodynamics
  • Published:
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Abstract

Objective

To investigate whether leptin receptor (LEPR) 223A>G polymorphism influences serum lipid levels and whether this polymorphism affects the effectiveness of simvastatin in Chinese patients with coronary heart disease (CHD).

Methods

A total of 312 patients with CHD were treated with simvastatin 20 mg/day. Fasting serum lipids were determined before and after 12 weeks of treatment.

Results

Patients with AA genotype had significantly higher total cholesterol (TC) levels and lower high-density lipoprotein cholesterol (HDL-C) levels than those with GG genotype (P < 0.05) before simvastatin treatment. In addition, the ability of simvastatin to increase HDL-C levels was significantly lower in patients with AA genotype than those with GG genotype (P < 0.05).

Conclusions

The 223A>G polymorphism of LEPR significantly modulates the HDL-C response to simvastatin in Chinese patients with CHD.

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Authors and Affiliations

  1. Department of Cardiac Care Unit, First Clinical Hospital of Harbin Medical University, 23 Post Rd., Nangang Region, Harbin, 150001, China

    Yan-Ming Sun, Lan-Feng Wang, Jia Li, Zhu-Qin Li & Wei Pan

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  1. Yan-Ming Sun
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  2. Lan-Feng Wang
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  3. Jia Li
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  4. Zhu-Qin Li
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  5. Wei Pan
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Corresponding author

Correspondence to Lan-Feng Wang.

Additional information

Yan-Ming Sun and Jia Li contributed equally to this study.

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Sun, YM., Wang, LF., Li, J. et al. The 223A>G polymorphism of the leptin receptor gene and lipid-lowering efficacy of simvastatin in Chinese patients with coronary heart disease. Eur J Clin Pharmacol 65, 157–161 (2009). https://doi.org/10.1007/s00228-008-0578-3

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  • DOI: https://doi.org/10.1007/s00228-008-0578-3

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