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Phosphatidylinositol Phosphate Kinases Put PI4,5P2 in Its Place

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Abstract

Phosphatidylinositol 4,5 bisphosphate (PI4,5P2) is a critical second messenger that regulates a myriad of diverse cellular activities including modulation of the actin cytoskeleton, vesicle trafficking, focal adhesion formation, and nuclear events. In order to effectively regulate these disparate cellular events, synthesis of PI4,5P2 by phosphatidylinositol phosphate kinases (PIP kinases) must be both spatially and temporally regulated. Two subfamilies of PIP kinases, types I and II, allow the generation of PI4,5P2 from independent pools of substrate, PI(4)P and PI(5)P respectively. In turn, type I and II PIP kinases show different subcellular localization and thus are involved in distinct signaling pathways. Additionally, several type I isoforms, and their splice variants, have now been shown to be differentially localized throughout the cell and to be involved in the synthesis of PI4,5P2 at distinct sites. These findings implicate PIP kinases as the major regulators of PI4,5P2-mediated events, making them key signaling enzymes in a variety of processes. Understanding the mechanisms regulating spatial and temporal synthesis of PI4,5P2 by PIP kinases is vital for understanding these processes as a whole. This review examines both structural and regulatory features that modulate activity, localization, and substrate usage of PIPKs.

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References

  1. R.A. Anderson I.V. Boronenkov S.D. Doughman J. Kunz J.C. Loijens (1999) ArticleTitlePhosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes. J. Biol. Chem. 274 9907–9910 Occurrence Handle10.1074/jbc.274.15.9907 Occurrence Handle1:CAS:528:DyaK1MXis1GjsL4%3D Occurrence Handle10187762

    Article  CAS  PubMed  Google Scholar 

  2. L.S. Arneson J. Kunz R.A. Anderson L.M. Traub (1999) ArticleTitleCoupled inositide phosphorylation and phospholipase D activation initiates clathrin-coat assembly on lysosomes. J. Biol. Chem. 274 17794–17805 Occurrence Handle10.1074/jbc.274.25.17794 Occurrence Handle1:CAS:528:DyaK1MXktVyls70%3D Occurrence Handle10364223

    Article  CAS  PubMed  Google Scholar 

  3. K.R. Auger L.A. Serunian S.P. Soltoff P. Libby L.C. Cantiey (1989) ArticleTitlePDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell 57 167–175 Occurrence Handle1:CAS:528:DyaL1MXkvFCktrc%3D

    CAS  Google Scholar 

  4. K.R. Ayscough (1998) ArticleTitleIn vivo functions of actin-binding proteins. Curr. Opin. Cell Biol. 10 102–111 Occurrence Handle10.1016/S0955-0674(98)80092-6 Occurrence Handle1:CAS:528:DyaK1cXhtFSjsr0%3D Occurrence Handle9484601

    Article  CAS  PubMed  Google Scholar 

  5. T. Balla T. Bondeva P. Varnai (2000) ArticleTitleHow accurately can we image inositol lipid in living cells? Trends Pharm. Sci. 21 238–241 Occurrence Handle10.1016/S0165-6147(00)01500-5 Occurrence Handle1:CAS:528:DC%2BD3cXkvVyrt78%3D Occurrence Handle10871889

    Article  CAS  PubMed  Google Scholar 

  6. M.A. Barbieri CM. Heath E.M. Peters A. Wells J.N. Davis P.D. Stahl (2001) ArticleTitlePhosphatidylinositol-4-phosphate 5-kinase-1beta is essential for epidermal growth factor receptor-mediated endocytosis. J. Biol. Chem. 276 47212–47216 Occurrence Handle10.1074/jbc.C100490200 Occurrence Handle1:CAS:528:DC%2BD3MXpt1Gnur8%3D Occurrence Handle11581249

    Article  CAS  PubMed  Google Scholar 

  7. I.V. Boronenkov J.C. Loijens M. Umeda R.A. Anderson (1998) ArticleTitlePhosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors. Mol. Biol. Cell. 9 3547–3560 Occurrence Handle1:CAS:528:DyaK1cXnvFOmtbg%3D Occurrence Handle9843587

    CAS  PubMed  Google Scholar 

  8. F.D. Brown A.L. Rozelle H.L. Yin T. Balla J.G. Donaldson (2001) ArticleTitlePhosphatidylinositol 4,5 bisphosphate and Arf6-regulated membrane traffic. J. Cell. Biol. 154 1007–1017 Occurrence Handle10.1083/jcb.200103107 Occurrence Handle1:CAS:528:DC%2BD3MXms1Slu7o%3D Occurrence Handle11535619

    Article  CAS  PubMed  Google Scholar 

  9. R.J. Botelho M. Teruel R. Dierckman R. Anderson A. Wells J.D. York T. Meyer S. Grinstein (2000) ArticleTitleLocalized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. J. Cell. Biol. 151 1353–1368 Occurrence Handle10.1083/jcb.151.7.1353 Occurrence Handle1:CAS:528:DC%2BD3MXoslam Occurrence Handle11134066

    Article  CAS  PubMed  Google Scholar 

  10. A.M. Castellino G.J. Parker I.V. Boronenkov R.A. Anderson M.V. Chao (1997) ArticleTitleA novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. J. Biol. Chem. 272 5861–587 Occurrence Handle10.1074/jbc.272.9.5861 Occurrence Handle1:CAS:528:DyaK2sXhslartLc%3D Occurrence Handle9038203

    Article  CAS  PubMed  Google Scholar 

  11. N.E. Chatah C.S. Abrams (2001) ArticleTitleG-protein-coupled receptor activation induces the membrane translocation and activation of phosphatidylinositol-4-phosphate 5-kinase I alpha by a Rac- and Rho-dependent pathway. J. Biol. Chem. 276 34059–34065 Occurrence Handle10.1074/jbc.M104917200 Occurrence Handle1:CAS:528:DC%2BD3MXmslylur8%3D Occurrence Handle11431481

    Article  CAS  PubMed  Google Scholar 

  12. L.D. Chong A. Traynor-Kaplan G.M. Bokoch M.A. Schwartz (1994) ArticleTitleThe small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell 79 507–513 Occurrence Handle1:CAS:528:DyaK2cXmvFOrtbc%3D Occurrence Handle7954816

    CAS  PubMed  Google Scholar 

  13. S. Cockcroft M.A. De Matteis (2001) ArticleTitleInositol lipids as spatial regulators of membrane traffic. J. Membrane Biol. 180 187–194 Occurrence Handle10.1007/s002320010069 Occurrence Handle1:STN:280:DC%2BD3Mris1Gqsw%3D%3D

    Article  CAS  Google Scholar 

  14. M.G. Coppolino R. Dierckman J. Loijens R.F. Collins M. Pouladi J. Jongstra-Bilen A.D. Schreiber W.S. Trimble R. Anderson S. Grinstein (2002) ArticleTitleInhibition of phosphatidylinositol-4-phosphate 5-kinase Ia impairs localized actin remodelling and suppresses phagocytosis. J. Biol. Chem. 277 43849–43857 Occurrence Handle10.1074/jbc.M209046200 Occurrence Handle1:CAS:528:DC%2BD38Xos1aksrw%3D Occurrence Handle12223494

    Article  CAS  PubMed  Google Scholar 

  15. M.P. Czech (2000) ArticleTitlePI4,5P2 and PI4,5P3: complex roles at the cell surface. Cell 100 603–606 Occurrence Handle1:CAS:528:DC%2BD3cXitFeksrs%3D Occurrence Handle10761925

    CAS  PubMed  Google Scholar 

  16. J.N. Davis C.O. Rock M. Cheng J.B. Watson R.A. Ashmun H. Kirk R.J. Kay M.F. Roussel (1997) ArticleTitleComplementation of growth factor receptor-dependent mitogenic signaling by a truncated type I phosphatidylinositol-4-phosphate 5-kinase. Mol. Cell Biol. 17 7398–7406 Occurrence Handle1:CAS:528:DyaK2sXnsFWgtr8%3D Occurrence Handle9372970

    CAS  PubMed  Google Scholar 

  17. S. Desrivieres F.T. Cooke P.J. Parker M.N. Hall (1998) ArticleTitleMSS4, a phosphatidylinositol-4-phosphate 5-kinase required for organization of the actin cytoskeleton in Saccharomyces cerevisiae. J. Biol. Chem. 273 15787–15793 Occurrence Handle10.1074/jbc.273.25.15787 Occurrence Handle1:CAS:528:DyaK1cXktVSlsrc%3D Occurrence Handle9624178

    Article  CAS  PubMed  Google Scholar 

  18. D. DeWald (2002) ArticleTitlePhosphoinositide signaling: vac to the future in fabl kinase regulation. Curr. Biol. 12 R491–R492 Occurrence Handle10.1016/S0960-9822(02)00966-1 Occurrence Handle1:CAS:528:DC%2BD38XmtlKgsL8%3D Occurrence Handle12176349

    Article  CAS  PubMed  Google Scholar 

  19. G. Di Paolo L. Pellegrini K. Letinic G. Cestra R. Zoncu S. Voronov S. Chang J. Guo M.R. Wenk P. De Camilli (2002) ArticleTitleRecruitment and regulation of phosphatidylinositol phosphate kinase type 1gamma by the FERM domain of talin. Nature 420 85–89 Occurrence Handle10.1038/nature01147 Occurrence Handle1:CAS:528:DC%2BD38XosVCmu7g%3D Occurrence Handle12422219

    Article  CAS  PubMed  Google Scholar 

  20. J.D. Gary A.E. Wurmser C.J. Bonangelino L.S. Weisman S.D. Emr (1998) ArticleTitleFab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vascuolar size and membrane homeostasis. J. Cell Biol. 143 65–79 Occurrence Handle10.1083/jcb.143.1.65 Occurrence Handle1:CAS:528:DyaK1cXmsFaltr8%3D Occurrence Handle9763421

    Article  CAS  PubMed  Google Scholar 

  21. A.P. Gilmore K. Burridge (1996) ArticleTitleRegulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate. Nature 381 531–535 Occurrence Handle10.1038/381531a0 Occurrence Handle1:CAS:528:DyaK28XjsVWisbg%3D Occurrence Handle8632828

    Article  CAS  PubMed  Google Scholar 

  22. A. Godi P. Pertile R. Meyers P. Marra G. Di Tullio C. Iurisci A. Luini D. Corda M.A. De Matteis (1999) ArticleTitleARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex. Nat. Cell Biol. 1 280–287 Occurrence Handle10.1038/12993 Occurrence Handle1:CAS:528:DyaK1MXlvFChu7s%3D Occurrence Handle10559940

    Article  CAS  PubMed  Google Scholar 

  23. J.R. Halstead M. Roefs C.D. Ellson S. D'Andrea C. Chen C.S. D'Santos N. Divecha (2001) ArticleTitleA novel pathway of cellular phosphatidylinositol(3,4,5)-trisphosphate synthesis is regulated by oxidative stress. Curr. Biol. 11 386–395 Occurrence Handle10.1016/S0960-9822(01)00121-X Occurrence Handle1:CAS:528:DC%2BD3MXis1Sjtr0%3D Occurrence Handle11301249

    Article  CAS  PubMed  Google Scholar 

  24. J.H. Hartwig D.J. Kwiatkowski (1991) ArticleTitleActin-binding proteins. Curr. Opin. Cell Biol. 3 87–97 Occurrence Handle1:CAS:528:DyaK3MXltlSisLc%3D Occurrence Handle1854489

    CAS  PubMed  Google Scholar 

  25. J.C. Hay P.L. Fisette G.H. Jenkins K. Fukami T. Takenawa R.A. Anderson T.F. Martin (1995) ArticleTitleATP-dependent inositide phosphorylation required for Ca2+-activated secretion. Nature 374 173–177 Occurrence Handle10.1038/374173a0 Occurrence Handle1:CAS:528:DyaK2MXkt1yisrY%3D Occurrence Handle7877690

    Article  CAS  PubMed  Google Scholar 

  26. H.N. Higgs T.D. Pollard (2000) ArticleTitleActivation by Cdc42 and PI4,5P(2) of Wiskott Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex. J. Cell Biol. 150 1311–1320 Occurrence Handle10.1083/jcb.150.6.1311 Occurrence Handle1:CAS:528:DC%2BD3cXmslGmur0%3D Occurrence Handle10995437

    Article  CAS  PubMed  Google Scholar 

  27. K. Homma S. Terui M. Minemura H. Qadota Y. Anraku Y. Kanaho Y. Ohya (1998) ArticleTitlePhosphatidylinositol-4-phosphate 5-kinase localized on the plasma membrane is essential for yeast cell morphogenesis. J. Biol. Chem. 273 15779–15786 Occurrence Handle10.1074/jbc.273.25.15779 Occurrence Handle1:CAS:528:DyaK1cXktVSlsrY%3D Occurrence Handle9624177

    Article  CAS  PubMed  Google Scholar 

  28. A. Honda M. Nogami T. Yokozeki M. Yamazaki H. Nakamura H. Watanabe K. Kawamoto K. Nakayama A.J. Morris M.A. Frohman Y. Kanaho (1999) ArticleTitlePhosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell 99 521–532 Occurrence Handle1:CAS:528:DyaK1MXnvVSisL0%3D Occurrence Handle10589680

    CAS  PubMed  Google Scholar 

  29. O.C. Ikonomov D. Sbrissa K. Mlak M. Kanzaki J. Pessin A. Shisheva (2002) ArticleTitleFunctional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity. J. Biol. Chem. 277 9206–9211 Occurrence Handle10.1074/jbc.M108750200 Occurrence Handle1:CAS:528:DC%2BD38Xitl2ksL4%3D Occurrence Handle11714711

    Article  CAS  PubMed  Google Scholar 

  30. H. Ishihara Y. Shibasaki N. Kizuki H. Katagiri Y. Yazaki T. Asano Y. Oka (1996) ArticleTitleCloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. J. Biol. Chem. 271 23611–23614 Occurrence Handle10.1074/jbc.271.39.23611 Occurrence Handle1:CAS:528:DyaK28XlvFSltrc%3D Occurrence Handle8798574

    Article  CAS  PubMed  Google Scholar 

  31. H. Ishihara Y. Shibasaki N. Kizuki T. Wada Y. Yazaki T. Asano Y. Oka (1998) ArticleTitleType I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. J. Biol. Chem. 273 8741–8748 Occurrence Handle10.1074/jbc.273.15.8741 Occurrence Handle1:CAS:528:DyaK1cXis1elt78%3D Occurrence Handle9535851

    Article  CAS  PubMed  Google Scholar 

  32. T. Itoh T. Ijuin T. Takenawa (1998) ArticleTitleA novel phosphatidylinositol-5-phosphate 4-kinase (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated in the endoplasmic reticulum in response to mitogenic signals. J. Biol. Chem. 273 20292–20299 Occurrence Handle10.1074/jbc.273.32.20292 Occurrence Handle1:CAS:528:DyaK1cXlsVWgt7c%3D Occurrence Handle9685379

    Article  CAS  PubMed  Google Scholar 

  33. T. Itoh H. Ishihara Y. Shibasaki Y. Oka T. Takenawa (2000) ArticleTitleAutophosphorylation of type I phosphatidylinositol phosphate kinase regulates its lipid kinase activity. J. Biol. Chem. 275 19389–19394 Occurrence Handle10.1074/jbc.M000426200 Occurrence Handle1:CAS:528:DC%2BD3cXksVGrsL4%3D Occurrence Handle10777481

    Article  CAS  PubMed  Google Scholar 

  34. G.H. Jenkins P.L. Fisette R.A. Anderson (1994) ArticleTitleType I phosphatidylinositol 4-phosphate 5-kinase isoforms are specifically stimulated by phosphatidic acid. J. Biol. Chem. 269 11547–11554 Occurrence Handle1:CAS:528:DyaK2cXktVeksrk%3D Occurrence Handle8157686

    CAS  PubMed  Google Scholar 

  35. R.P. Johnson S.W. Craig (2000) ArticleTitleActin activates a cryptic dimerization potential of the vinculin tail domain. J. Biol. Chem. 275 95–105 Occurrence Handle10.1074/jbc.275.1.95 Occurrence Handle1:CAS:528:DC%2BD3cXjvVGluw%3D%3D Occurrence Handle10617591

    Article  CAS  PubMed  Google Scholar 

  36. D.R. Jones M.A. Sanjuan I. Merida (2000) ArticleTitleType Ialpha phosphatidylinositol 4-phosphate 5-kinase is a putative target for increased intracellular phosphatidic acid. FEBS Lett. 476 160–165 Occurrence Handle10.1016/S0014-5793(00)01702-6 Occurrence Handle1:CAS:528:DC%2BD3cXksFeksLo%3D Occurrence Handle10913605

    Article  CAS  PubMed  Google Scholar 

  37. J. Kunz A. Fuelling L. Kolbe R.A. Anderson (2002) ArticleTitleStereo-specific substrate recognition by phosphatidylinositol phosphate kinases is swapped by changing a single amino acid residue. J. Biol. Chem. 277 5611–5619 Occurrence Handle10.1074/jbc.M110775200 Occurrence Handle1:CAS:528:DC%2BD38XhsFCjtLg%3D Occurrence Handle11733501

    Article  CAS  PubMed  Google Scholar 

  38. J. Kunz M.P. Wilson M. Kisseleva J.H. Hurley P.W. Majerus R.A. Anderson (2000) ArticleTitleThe activation loop of phosphatidylinositol phosphate kinases determines signaling specificity. Mol. Cell 5 1–11 Occurrence Handle1:CAS:528:DC%2BD3cXpvFKgug%3D%3D Occurrence Handle10678164

    CAS  PubMed  Google Scholar 

  39. D.A. Lauffenburger A.F. Horwitz (1996) ArticleTitleCell migration: a physically integrated molecular process. Cell 84 359–369 Occurrence Handle1:CAS:528:DyaK28XhtFWqtr8%3D Occurrence Handle8608589

    CAS  PubMed  Google Scholar 

  40. E. Lee P. De Camilli (2002) ArticleTitleDynamin at actin tails. Proc. Natl. Acad. Sci. U SA 99 161–166 Occurrence Handle10.1073/pnas.012607799 Occurrence Handle1:CAS:528:DC%2BD38Xlt1CgsQ%3D%3D

    Article  CAS  Google Scholar 

  41. K. Ling R.L. Doughman A.J. Firestone M.W. Bunce R.A. Anderson (2002) ArticleTitleType Igamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature 420 89–93 Occurrence Handle10.1038/nature01082 Occurrence Handle1:CAS:528:DC%2BD38XosVCmurY%3D Occurrence Handle12422220

    Article  CAS  PubMed  Google Scholar 

  42. J.C. Loijens R.A. Anderson (1996) ArticleTitleType I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family. J. Biol. Chem. 271 32937–32943 Occurrence Handle10.1074/jbc.271.51.32937 Occurrence Handle1:CAS:528:DyaK2sXnt1am Occurrence Handle8955136

    Article  CAS  PubMed  Google Scholar 

  43. M. Maekawa T. Eshizaki S. Boku N. Watanabe A. Fujita A. Iwamatsu T. Obinata K. Ohashi K. Mizuno S. Narumiya (1999) ArticleTitleSignaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 285 895–898

    Google Scholar 

  44. T.F. Martin (2001) ArticleTitlePI(4,5)P(2) regulation of surface membrane traffic. Curr. Opin. Cell Biol. 13 493–499 Occurrence Handle10.1016/S0955-0674(00)00241-6 Occurrence Handle1:CAS:528:DC%2BD3MXltVGisb0%3D Occurrence Handle11454457

    Article  CAS  PubMed  Google Scholar 

  45. T. Matsui S. Yonemura S. Tsukita (1999) ArticleTitleActivation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases. Curr. Biol. 9 1259–1262 Occurrence Handle10.1016/S0960-9822(99)80508-9 Occurrence Handle1:CAS:528:DyaK1MXnt1yqu7c%3D Occurrence Handle10556088

    Article  CAS  PubMed  Google Scholar 

  46. R.K. McEwen S.K. Dove F.T. Cooke G.F. Painter A.B. Holmes A. Shisheva Y. Ohya P.J. Parker R.H. Michell (1999) ArticleTitleComplementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases. J. Biol. Chem. 274 3905–33912

    Google Scholar 

  47. S. McLaughlin J. Wang A. Gambhir D. Murray (2002) ArticleTitlePI4,5P(2) and proteins: interactions, organization, and information flow. Annu. Rev. Biophys. Biomol. Struct. 31 151–175 Occurrence Handle10.1146/annurev.biophys.31.082901.134259 Occurrence Handle1:CAS:528:DC%2BD38XltVynurs%3D Occurrence Handle11988466

    Article  CAS  PubMed  Google Scholar 

  48. A. Miyazawa M. Umeda T. Torikoshi K. Yanagisawa T. Yoshioka K. Inoue (1988) ArticleTitleProduction and characterization of monoclonal antibodies that bind to phosphatidylinositol 4,5 bisphosphate. Mol. Immunol. 25 1025–1031 Occurrence Handle10.1016/0161-5890(88)90010-7 Occurrence Handle1:CAS:528:DyaL1MXhtFakurc%3D Occurrence Handle2851103

    Article  CAS  PubMed  Google Scholar 

  49. C.D. Nobes A. Hall (1995) ArticleTitleRho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81 53–62 Occurrence Handle1:CAS:528:DyaK2MXkvFOisrs%3D Occurrence Handle7536630

    CAS  PubMed  Google Scholar 

  50. J.D. Orth E.W. Krueger H. Cao M.A. McNiven (2002) ArticleTitleThe large GTPase dynamin regulates actin comet formation and movement in living cells. Proc. Natl. Acad. Sci. US A 99 167–172 Occurrence Handle10.1073/pnas.012607899 Occurrence Handle1:CAS:528:DC%2BD38Xlt1Cgtg%3D%3D

    Article  CAS  Google Scholar 

  51. P.A. Oude Weernink P. Schulte Y. Guo J. Wetzel M. Amano K. Kaibuchi S. Haverland M. Voss M. Schmidt G.W. Mayr K.H. Jakobs (2000) ArticleTitleStimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase. J. Biol. Chem. 275 10168–10174 Occurrence Handle10.1074/jbc.275.14.10168 Occurrence Handle1:STN:280:DC%2BD3c3gvFertQ%3D%3D Occurrence Handle10744700

    Article  CAS  PubMed  Google Scholar 

  52. S.J. Park T. Itoh T. Takenawa (2001) ArticleTitlePhosphatidylinositol phosphate 5-kinase type I is regulated through phosphorylation response by extracellular stimuli. J. Biol. Chem. 276 4781–4787 Occurrence Handle10.1074/jbc.M010177200 Occurrence Handle1:CAS:528:DC%2BD3MXhtlOqt7k%3D Occurrence Handle11087761

    Article  CAS  PubMed  Google Scholar 

  53. L.E. Rameh K.F. Tolias B.C. Duckworth L.C. Cantley (1997) ArticleTitleA new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. Nature 390 192–196 Occurrence Handle10.1038/36621 Occurrence Handle1:CAS:528:DyaK2sXnsVOntL0%3D Occurrence Handle9367159

    Article  CAS  PubMed  Google Scholar 

  54. P.A. Randazzo Z. Nie K. Miura V.W. Hsu (2000) ArticleTitleMolecular aspects of the cellular activities of ADP-ribosylation factors. Sci STKE 2000 RE1 Occurrence Handle1:STN:280:DC%2BD38%2FotFejsg%3D%3D

    CAS  Google Scholar 

  55. V.D. Rao S. Misra I.V. Boronenkov R.A. Anderson J.H. Hurley (1998) ArticleTitleStructure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. Cell 94 829–839 Occurrence Handle1:CAS:528:DyaK1cXmtlCjsLo%3D Occurrence Handle9753329

    CAS  PubMed  Google Scholar 

  56. X.D. Ren G.M. Bokoch A. Traynor-Kaplan G.H. Jenkins R.A. Anderson M.A. Schwartz (1996) ArticleTitlePhysical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells. Mol. Biol. Cell 7 435–442 Occurrence Handle1:CAS:528:DyaK28XhvVSmtb0%3D Occurrence Handle8868471

    CAS  PubMed  Google Scholar 

  57. R. Rohatgi H.Y. Ho M.W. Kirschner (2000) ArticleTitleMechanism of N-WASP activation by CDC42 and phosphatidylinositol 4,5-bisphosphate. J. Cell Biol. 150 1299–1310 Occurrence Handle10.1083/jcb.150.6.1299 Occurrence Handle1:CAS:528:DC%2BD3cXmslGmurw%3D Occurrence Handle10995436

    Article  CAS  PubMed  Google Scholar 

  58. A.L. Rozelle L.M. Machesky M. Yamamoto M.H. Driessens R.H. Insall M.G. Roth K. Luby-Phelps G. Marriott A. Hall H.L. Yin (2000) ArticleTitlePhosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. Curr. Biol. 10 311–320 Occurrence Handle10.1016/S0960-9822(00)00384-5 Occurrence Handle1:CAS:528:DC%2BD3cXitFegtrk%3D Occurrence Handle10744973

    Article  CAS  PubMed  Google Scholar 

  59. D. Sbrissa O.C. Ikonomov A. Shisheva (1999) ArticleTitlePIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin. J. Biol. Chem. 274 21589–21597 Occurrence Handle10.1074/jbc.274.31.21589 Occurrence Handle1:CAS:528:DyaK1MXltVyms7w%3D Occurrence Handle10419465

    Article  CAS  PubMed  Google Scholar 

  60. D. Sbrissa O.C. Ikonomov A. Shisheva (2002) ArticleTitlePhosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomembrane localization. J. Biol. Chem. 277 6073–6079 Occurrence Handle10.1074/jbc.M110194200 Occurrence Handle1:CAS:528:DC%2BD38XhvFyrtLo%3D Occurrence Handle11706043

    Article  CAS  PubMed  Google Scholar 

  61. A.S. Sechi J. Wehland (2000) ArticleTitleThe actin cytoskeleton and plasma membrane connection: PtdIns(4,5)P(2) influences cytoskeletal protein activity at the plasma membrane. J. Cell Sci. 113 3685–3695 Occurrence Handle1:CAS:528:DC%2BD3cXosVGmtL0%3D Occurrence Handle11034897

    CAS  PubMed  Google Scholar 

  62. Y. Shibasaki H. Ishihara N. Kizuki T. Asano Y. Oka Y. Yazaki (1997) ArticleTitleMassive actin polymerization induced by phosphatidylinositol-4-phosphate 5-kinase in vivo. J. Biol. Chem. 212 7578–7581

    Google Scholar 

  63. S.L. Shyng A. Barbieri A. Gumusboga C. Cukras L. Pike J.N. Davis P.D. Stahl C.G. Nichols (2000) ArticleTitleModulation of nucleotide sensitivity of ATP-sensitive potassium channels by phosphatidylinositol-4-phosphate 5-kinase. Proc. Natl. Acad. Sci. USA 97 937–941 Occurrence Handle10.1073/pnas.97.2.937 Occurrence Handle1:CAS:528:DC%2BD3cXot1alug%3D%3D Occurrence Handle10639183

    Article  CAS  PubMed  Google Scholar 

  64. A. Skippen D.H. Jones C.P. Morgan M. Li S. Cockcroft (2002) ArticleTitleMechanism of ADP ribosylation factor-stimulated phosphatidylinositol 4,5-bisphosphate synthesis in HL60 cells. J. Biol. Chem. 277 5823–5831 Occurrence Handle10.1074/jbc.M110274200 Occurrence Handle1:CAS:528:DC%2BD38XhvFyrsbw%3D Occurrence Handle11744730

    Article  CAS  PubMed  Google Scholar 

  65. J.V. Small T. Stradal E. Vignal K. Rottner (2002) ArticleTitleThe lamellipodium: where motility begins. Trends Cell Biol. 12 112–120 Occurrence Handle10.1016/S0962-8924(01)02237-1 Occurrence Handle1:CAS:528:DC%2BD38XhtlSmtLk%3D Occurrence Handle11859023

    Article  CAS  PubMed  Google Scholar 

  66. C.S. Stripp T.V. Kolesnikova M.E. Hemler (2003) ArticleTitleFunctional domains in tetraspanin proteins. Trends Biochem. Sci. 28 106–112 Occurrence Handle10.1016/S0968-0004(02)00014-2 Occurrence Handle12575999

    Article  PubMed  Google Scholar 

  67. A. Toker (1998) ArticleTitleThe synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate. Curr. Opin. Cell Biol. 10 254–261 Occurrence Handle10.1016/S0955-0674(98)80148-8 Occurrence Handle1:CAS:528:DyaK1cXisFyntLc%3D Occurrence Handle9561850

    Article  CAS  PubMed  Google Scholar 

  68. K.F. Tolias L.C. Cantley C.L. Carpenter (1995) ArticleTitleRho family GTPases bind to phosphoinositide kinases. J. Biol. Chem. 270 17656–17659 Occurrence Handle10.1074/jbc.270.30.17656 Occurrence Handle1:CAS:528:DyaK2MXnt1Crsbc%3D Occurrence Handle7629060

    Article  CAS  PubMed  Google Scholar 

  69. K.F. Tolias A.D. Couvillon L.C. Cantley C.L. Carpenter (1998) ArticleTitleCharacterization of a Rac1- and RhoGDI-associated lipid kinase signaling complex. Mol. Cell Biol. 18 762–770 Occurrence Handle1:CAS:528:DyaK1cXltlGrsA%3D%3D Occurrence Handle9447972

    CAS  PubMed  Google Scholar 

  70. K.F. Tolias L.E. Rameh H. Ishihara Y. Shibasaki J. Chen G.D. Prestwich L.C. Cantley C.L. Carpenter (1998) ArticleTitleType I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate. J. Biol. Chem. 273 18040–18046 Occurrence Handle10.1074/jbc.273.29.18040 Occurrence Handle1:CAS:528:DyaK1cXkvVChsLg%3D Occurrence Handle9660759

    Article  CAS  PubMed  Google Scholar 

  71. K.F. Tolias J.H. Hartwig H. Ishihara Y. Shibasaki L.C. Cantley C.L. Carpenter (2000) ArticleTitleType Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly. Curr. Biol. 10 153–156 Occurrence Handle10.1016/S0960-9822(00)00315-8 Occurrence Handle1:CAS:528:DC%2BD3cXht12hsLo%3D Occurrence Handle10679324

    Article  CAS  PubMed  Google Scholar 

  72. I. Vancurova J.H. Choi H. Lin J. Kuret A. Vancura (1999) ArticleTitleRegulation of phosphatidylinositol 4-phosphate 5-kinase from Schizosaccharomyces pombe by casein kinase I. J. Biol. Chem. 274 1147–1155 Occurrence Handle10.1074/jbc.274.2.1147 Occurrence Handle1:CAS:528:DyaK1MXmtFGqsg%3D%3D Occurrence Handle9873063

    Article  CAS  PubMed  Google Scholar 

  73. P.P. van Horck E. Lavazais B.J. Eickholt W.H. Moolenaar N. Divecha (2002) ArticleTitleEssential role of Type I(alpha) phosphatidylinositol 4-phosphate 5-kinase in neurite remodeling. Curr. Biol. 12 241–245 Occurrence Handle10.1016/S0960-9822(01)00660-1 Occurrence Handle1:CAS:528:DC%2BD38XhtlGnsrs%3D Occurrence Handle11839279

    Article  CAS  PubMed  Google Scholar 

  74. J. Van Rheenen K. Jalink (2002) ArticleTitleAgonist-induced PI4,5P(2) hydrolysis inhibits cortical actin dynamics: Regulation at a global but not at a micrometer scale. Mol. Biol. Cell 13 3257–3267 Occurrence Handle10.1091/mbc.E02-04-0231 Occurrence Handle1:CAS:528:DC%2BD38XntlGisLs%3D Occurrence Handle12221130

    Article  CAS  PubMed  Google Scholar 

  75. S.A. Watt G. Kular I.N. Fleming C.P. Downes J.M. Lucocq (2002) ArticleTitleSubcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta 1. Biochem. J. 363 651–666 Occurrence Handle10.1042/0264-6021:3630657

    Article  Google Scholar 

  76. P.A. Weernink Y. Guo C. Zhang M. Schmidt C. Von Eichel-Streiber K.H. Jakobs (2000) ArticleTitleControl of cellular phosphatidylinositol 4,5-bisphosphate levels by adhesion signals and rho GTPases in NIH 3T3 fibroblasts involvement of both phosphatidylinositol-4-phosphate 5-kinase and phospholipase C. Eur. J. Biochem. 267 5237–5246 Occurrence Handle10.1046/j.1432-1327.2000.01599.x Occurrence Handle1:STN:280:DC%2BD3cvpsFWnsw%3D%3D Occurrence Handle10931209

    Article  CAS  PubMed  Google Scholar 

  77. M.R. Wenk L. Pellegrini V.A. Klenchin G. Di Paolo S. Chang L. Daniell M. Arioka T.F. Martin P. De Camilli (2001) ArticleTitlePI4,5P kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse. Neuron 32 79–88 Occurrence Handle1:CAS:528:DC%2BD3MXnsl2ks7g%3D Occurrence Handle11604140

    CAS  PubMed  Google Scholar 

  78. A. Yamamoto D.B. DeWald I.V. Boronenkov R.A. Anderson S.D. Emr D. Koshland (1995) ArticleTitleNovel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast. Mol. J. Biol. Cell 6 525–539 Occurrence Handle1:CAS:528:DyaK2MXlsl2mt70%3D

    CAS  Google Scholar 

  79. M. Yamanoto D.H. Hilgemann S. Feng H. Bito H. Ishihara Y. Shibasaki H.L. Yin (2001) ArticleTitlePhosphatidylinositol 4,5-bisphosphate induces actin stress-fiber formation and inhibits membrane ruffling in CV1 cells. Cell Biol. 152 867–876 Occurrence Handle10.1083/jcb.152.5.867

    Article  Google Scholar 

  80. M. Yamazaki H. Miyazaki H. Watanabe T. Sasaki T. Maehama M.A. Frohman Y. Kanaho (2002) ArticleTitleA phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export. J. Biol. Chem. 277 17226–17230 Occurrence Handle10.1074/jbc.M109795200 Occurrence Handle1:CAS:528:DC%2BD38XjslWgs7g%3D Occurrence Handle11877391

    Article  CAS  PubMed  Google Scholar 

  81. J.D. York A.R. Odom R. Murphy E.B. Ives S.R. Wente (1999) ArticleTitleA phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export. Science 285 96–100 Occurrence Handle10.1126/science.285.5424.96 Occurrence Handle1:CAS:528:DyaK1MXksVCqsbY%3D Occurrence Handle10390371

    Article  CAS  PubMed  Google Scholar 

  82. X. Zhang J.C. Loijens I.V. Boronenkov G.J. Parker F.A. Norris J. Chen O. Thum G.D. Prestwich P.W. Majerus R.A. Anderson (1997) ArticleTitlePhosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules. J. Biol. Chem. 272 17756–17761 Occurrence Handle10.1074/jbc.272.28.17756 Occurrence Handle1:CAS:528:DyaK2sXksFyjsr8%3D Occurrence Handle9211928

    Article  CAS  PubMed  Google Scholar 

  83. R.L. Doughman A.J. Firestone M.L. Wojtasiak M.W. Bunce R.A. Anderson (2003) ArticleTitleMembrane ruffling requires coordination between type I phosphatidylinositol phosphate kinase and Rac signaling. J. Biol. Chem. 278 M211397200 Occurrence Handle10.1074/jbc.M211397200

    Article  Google Scholar 

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Doughman, R., Firestone, A. & Anderson, R. Phosphatidylinositol Phosphate Kinases Put PI4,5P2 in Its Place . J. Membrane Biol. 194, 77–89 (2003). https://doi.org/10.1007/s00232-003-2027-7

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