Skip to main content

Advertisement

Log in

Hepatoblastoma: an oncological review

  • Minisymposium
  • Published:
Pediatric Radiology Aims and scope Submit manuscript

Abstract

The treatment of hepatoblastoma is an example of the great advances made in paediatric oncology over the past few decades. Formerly a disease with a dreadful prognosis, children now have a 5-year survival rate of over 70%. This has been achieved by advances in surgical techniques and the use of chemotherapy. In future, we hope to be able to improve survival for children with high-risk tumours, and decrease the morbidity associated with treatment in the others.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Miller RW, Young JL Jr, Novakovic B (1995) Childhood cancer. Cancer 75:395–405

    Article  PubMed  CAS  Google Scholar 

  2. Stocker JT, Schmidt D (2000) Hepatoblastoma. In: Hamilton SR, Aaltonen LA (eds) World Health Organization Classification of tumors. Pathology and genetics of tumors of the digestive system. IARC Press, Lyon, pp 184–189

    Google Scholar 

  3. DeBaun MR, Tucker MA (1998) Risk of cancer during the first four years of life in children from The Beckwith-Wiedemann Syndrome Registry. J Pediatr 132:398–400

    Article  PubMed  CAS  Google Scholar 

  4. Oda H, Imai Y, Nakatsuru Y, et al (1996) Somatic mutations of the APC gene in sporadic hepatoblastomas. Cancer Res 56:3320–3323

    PubMed  CAS  Google Scholar 

  5. Prokurat A, Kluge P, Kosciesza A, et al (2002) Transitional liver cell tumors (TLCT) in older children and adolescents: a novel group of aggressive hepatic tumors expressing beta-catenin. Med Pediatr Oncol 39:510–518

    Article  PubMed  Google Scholar 

  6. Zimmermann A (2005) The emerging family of hepatoblastoma tumours: from ontogenesis to oncogenesis. Eur J Cancer 41:1503–1514

    Article  PubMed  Google Scholar 

  7. Haas JE, Muczynski KA, Krailo M, et al (1989) Histopathology and prognosis in childhood hepatoblastoma and hepatocarcinoma. Cancer 64:1082–1095

    Article  PubMed  CAS  Google Scholar 

  8. Ortega JA, Douglass EC, Feusner JH, et al (2000) Randomized comparison of cisplatin/vincristine/fluorouracil and cisplatin/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: a report from the Children’s Cancer Group and the Pediatric Oncology Group. J Clin Oncol 18:2665–2675

    PubMed  CAS  Google Scholar 

  9. Exelby PR, Filler RM, Grosfeld JL (1975) Liver tumors in children in the particular reference to hepatoblastoma and hepatocellular carcinoma: American Academy of Pediatrics Surgical Section Survey–1974. J Pediatr Surg 10:329–337

    Article  PubMed  CAS  Google Scholar 

  10. Lack EE, Neave C, Vawter GF (1982) Hepatoblastoma. A clinical and pathologic study of 54 cases. Am J Surg Pathol 6: 693–705

    Article  PubMed  CAS  Google Scholar 

  11. Kuo CY, Liu HC, Chang MH, et al (1991) Hepatoblastoma in infancy and childhood: a clinical and pathological study of 32 cases. Zhonghua Minguo Xiaoer Keyi Xuehui Zazhi 32:79–87

    CAS  Google Scholar 

  12. Tiao GM, Bobey N, Allen S, et al (2005) The current management of hepatoblastoma: a combination of chemotherapy, conventional resection, and liver transplantation. J Pediatr 146:204–211

    Article  PubMed  Google Scholar 

  13. Ortega JA, Krailo MD, Haas JE, et al (1991) Effective treatment of unresectable or metastatic hepatoblastoma with cisplatin and continuous infusion doxorubicin chemotherapy: a report from the Children’s Cancer Study Group. J Clin Oncol 9:2167–2176

    PubMed  CAS  Google Scholar 

  14. Pritchard J, Brown J, Shafford E, et al (2000) Cisplatin, doxorubicin, and delayed surgery for childhood hepatoblastoma: a successful approach—results of the first prospective study of the International Society of Pediatric Oncology. J Clin Oncol 18:3819–3828

    PubMed  CAS  Google Scholar 

  15. Perilongo G, Shafford E, Maibach R, et al (2004) Risk-adapted treatment for childhood hepatoblastoma. Final report of the second study of the International Society of Paediatric Oncology—SIOPEL 2. Eur J Cancer 40:411–421

    Article  PubMed  CAS  Google Scholar 

  16. Douglass EC, Green AA, Wrenn E, et al (1985) Effective cisplatin (DDP) based chemotherapy in the treatment of hepatoblastoma. Med Pediatr Oncol 13:187–190

    Article  PubMed  CAS  Google Scholar 

  17. Evans AE, Land VJ, Newton WA, et al (1982) Combination chemotherapy (vincristine, adriamycin, cyclophosphamide, and 5-fluorouracil) in the treatment of children with malignant hepatoma. Cancer 50:821–826

    Article  PubMed  CAS  Google Scholar 

  18. Quinn JJ, Altman AJ, Robinson HT, et al (1985) Adriamycin and cisplatin for hepatoblastoma. Cancer 56:1926–1929

    Article  PubMed  CAS  Google Scholar 

  19. Lemerle J, Voute PA, Tournade MF, et al (1983) Effectiveness of preoperative chemotherapy in Wilms’ tumor: results of an International Society of Paediatric Oncology (SIOP) clinical trial. J Clin Oncol 1:604–609

    PubMed  CAS  Google Scholar 

  20. Czauderna P, Otte J-B, Roebuck DJ (2006) Surgical treatment of hepatoblastoma in children. Pediatr Radiol 36

  21. Brown J, Perilongo G, Shafford E, et al (2000) Pretreatment prognostic factors for children with hepatoblastoma—results from the International Society of Paediatric Oncology (SIOP) study SIOPEL 1. Eur J Cancer 36:1418–1425

    Article  PubMed  CAS  Google Scholar 

  22. Perilongo G, Shafford E, Maibach R, et al (2004) Risk-adapted treatment for childhood hepatoblastoma. final report of the second study of the International Society of Paediatric Oncology–SIOPEL 2. Eur J Cancer 40:411–421

    Article  PubMed  CAS  Google Scholar 

  23. Von Schweinitz D, Hecker H, Schmidt-von-Arndt G, et al (1997) Prognostic factors and staging systems in childhood hepatoblastoma. Int J Cancer 74:593–599

    Article  Google Scholar 

  24. Von Schweinitz D, Hecker H, Harms D, et al (1995) Complete resection before development of drug resistance is essential for survival from advanced hepatoblastoma—a report from the German Cooperative Pediatric Liver Tumor Study HB-89. J Pediatr Surg 30:845–852

    Article  PubMed  Google Scholar 

  25. Douglass EC, Reynolds M, Finegold M, et al (1993) Cisplatin, vincristine, and fluorouracil therapy for hepatoblastoma: a Pediatric Oncology Group study. J Clin Oncol 11:96–99

    PubMed  CAS  Google Scholar 

  26. Katzenstein HM, London WB, Douglass EC, et al (2002) Treatment of unresectable and metastatic hepatoblastoma: a Pediatric Oncology Group phase II study. J Clin Oncol 20:3438–3444

    Article  PubMed  Google Scholar 

  27. Haberle B, Bode U, Von Schweinitz D (2003) Differentiated treatment protocols for high- and standard-risk hepatoblastoma—an interim report of the German Liver Tumor Study HB99. Klin Padiatr 215:159–165

    Article  PubMed  CAS  Google Scholar 

  28. Sasaki F, Matsunaga T, Iwafuchi M, et al (2002) Outcome of hepatoblastoma treated with the JPLT-1 (Japanese Study Group for Pediatric Liver Tumor) Protocol-1: a report from the Japanese Study Group for Pediatric Liver Tumor. J Pediatr Surg 37:851–856

    Article  PubMed  CAS  Google Scholar 

  29. Zamzam MA, Elmalt O, Kassem HA, et al (2004) Multidisciplinary treatment in children with non-metastatic hepatoblastoma: treatment results at the National Cancer Institute, Cairo University. J Egypt Natl Cancer Inst 16:92–98

    Google Scholar 

  30. Chan KL, Fan ST, Tam PK, et al (2002) Paediatric hepatoblastoma and hepatocellular carcinoma: retrospective study. Hong Kong Med J 8:13–17

    PubMed  CAS  Google Scholar 

  31. Tsai HL, Liu CS, Chin TW, et al (2004) Hepatoblastoma and hepatocellular carcinoma in children. J Chin Med Assoc 67:83–88

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Derek J. Roebuck.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Roebuck, D.J., Perilongo, G. Hepatoblastoma: an oncological review. Pediatr Radiol 36, 183–186 (2006). https://doi.org/10.1007/s00247-005-0064-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00247-005-0064-3

Keywords

Navigation