Abstract
The objectives of this study were to determine whether recombinant human bone morphogenetic protein-2 (rhBMP-2) can be used as the sole stimulator of osteogenesis with success equal to an autologous graft in posterolateral lumbar fusion (PLF) at the same level and to describe the progress until bone union. This study included 11 patients who underwent PLF of L4-5. On the right side, only rhBMP-2, for which polylactic/glycolic acid (PLGA) was used as a carrier, was used, whereas, on the left side, autogenous bone was used. The bone union rate was 73 and 82% at 12 and 24 months after surgery, respectively, on the right BMP side, while the rate on the autogenous bone side was 91%. There was no statistically significant difference in the bone union rate. rhBMP-2 can be used as the sole source of osteogenesis with success equivalent to an autologous graft of the PLF.
Résumé
L’objectif de cette étude est de déterminer si la BMP humaine recombinante rhBMP-2 peut être utilisée comme le seul stimulateur de l’ostéogénèse avec un résultat équivalent à une autogreffe lors des fusions postéro-latérales lombaires. Méthode : 11 patients ayant bénéficié d’une greffe postéro-latérale de L4 – L5 ont été inclus dans cette étude. Du côté droit a été mis en place uniquement de la BMP recombinante avec comme support le PLGA et du côté gauche une auto-greffe osseuse. Résultat : le taux de fusion a été respectivement de 73% et de 82% à 12 et 24 mois du côté BMP alors que du côté de la greffe, le taux de fusion est de 91%. Il n’y a pas de différence significative entre ces deux méthodes. En conclusion : la BMP recombinante rhBMP-2 peut être utilisée comme seule source d’ostéogénèse avec un succès à peu près équivalent à celui de l’autogreffe.
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Katayama, Y., Matsuyama, Y., Yoshihara, H. et al. Clinical and radiographic outcomes of posterolateral lumbar spine fusion in humans using recombinant human bone morphogenetic protein-2: an average five-year follow-up study. International Orthopaedics (SICOT) 33, 1061–1067 (2009). https://doi.org/10.1007/s00264-008-0600-5
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DOI: https://doi.org/10.1007/s00264-008-0600-5