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A ‘natural’ mutation in Saccharomyces cerevisiae strains derived from S288c affects the complex regulatory gene HAP1 (CYP1)

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Abstract

The HAP1 gene encodes a complex transcriptional regulator of many genes involved in electron-transfer reactions and is essential in anaerobic or heme-depleted conditions. We show here that strains derived from S288c carry a defective Ty1 element inserted in the 3′ region of the HAP1 ORF. This mutant allele acts as a HAP1 null allele in terms of cytochrome c expression and CYC1 UAS1-dependent transcription, but is able to sustain limited growth in heme-depleted conditions.

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Authors and Affiliations

  1. Centre de Génétique Moléculaire, Laboratoire propre du CNRS associéà l'Université Pierre et Marie Curie, F-91198, Gif-sur-Yvette, France e-mail: Herbert@CGM.CNRS-GIF.FR Tel.: +33-1-69 82 31 91 Fax: +33-1-69 07 55 39, , , , , , FR

    M. Gaisne, A.-M. Bécam, J. Verdière & C. J. Herbert

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  1. M. Gaisne
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  2. A.-M. Bécam
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  3. J. Verdière
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  4. C. J. Herbert
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Received: 31 March / 22 June 1999

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Gaisne, M., Bécam, AM., Verdière, J. et al. A ‘natural’ mutation in Saccharomyces cerevisiae strains derived from S288c affects the complex regulatory gene HAP1 (CYP1). Curr Genet 36, 195–200 (1999). https://doi.org/10.1007/s002940050490

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  • DOI: https://doi.org/10.1007/s002940050490

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