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Autonomic dysfunction in systemic lupus erythematosus

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Abstract

The objectives were to study the frequency and pattern of autonomic dysfunction in systemic lupus erythematosus (SLE). Fifty-one patients of SLE and 30 age- and sex-matched healthy controls were studied prospectively using a standard battery of noninvasive tests. Autonomic symptoms were seen in 37% patients. On laboratory testing incipient dysfunction was seen in 9 (18%) cases and 1 (3%) control, while atypical involvement was seen in 11 (21%) cases and 6 (20%) controls. Autonomic dysfunction did not correlate with disease duration, lupus activity, disease damage, any particular organ involvement or the presence/absence of peripheral neuropathy. Autonomic neuropathy is not uncommon in lupus and may exist independent of peripheral neuropathy. There are no specific clinical predictors. The clinical significance of autonomic dysfunction detected by laboratory testing warrants longitudinal studies.

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Authors and Affiliations

  1. Department of Medicine, All India Institute of Medical Sciences, 110029, New Delhi, India

    Shalimar, Rohini Handa & Praveen Aggarwal

  2. Department of Physiology, All India Institute of Medical Sciences, New Delhi, India

    Kishore Kumar Deepak

  3. Department of Neurology, All India Institute of Medical Sciences, New Delhi, India

    Manvir Bhatia

  4. Department of Bio-statistics, All India Institute of Medical Sciences, New Delhi, India

    Ravindra Mohan Pandey

Authors
  1. Shalimar
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  2. Rohini Handa
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  3. Kishore Kumar Deepak
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  4. Manvir Bhatia
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  5. Praveen Aggarwal
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  6. Ravindra Mohan Pandey
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Corresponding author

Correspondence to Rohini Handa.

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Shalimar, Handa, R., Deepak, K.K. et al. Autonomic dysfunction in systemic lupus erythematosus. Rheumatol Int 26, 837–840 (2006). https://doi.org/10.1007/s00296-005-0093-0

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  • DOI: https://doi.org/10.1007/s00296-005-0093-0

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