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Early mammographic and sonographic findings after intraoperative radiotherapy (IORT) as a boost in patients with breast cancer

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Abstract

The aim of this study was to evaluate mammographic and sonographic changes at the surgical site within the first 2 years after IORT as a boost followed by whole-breast radiotherapy (WBRT), compared with a control group treated with WBRT alone. All patients had breast-conserving surgery for early-stage breast cancer. Group A: n = 27, IORT (20 Gy) followed by WBRT (46 Gy). Group B (control group): n = 27, WBRT alone (56–66 Gy). Mammography: fat necrosis in 14 group A versus four group B patients (P < 0.001); parenchymal scarring classified as unorganized at the last follow-up in 16 vs seven cases, respectively (P = 0.03). Ultrasound: overall number of patients with circumscribed findings 27 vs 18 (P < 0.001); particular hematomas/seromas in 26 vs 13 patients (P < 0.001). Synopsis of mammography and ultrasound: overall postoperative changes were significantly higher classified in group A (P = 0.01), but not judged to have a significantly higher impact on interpretation. Additional diagnostic procedures, due to unclear findings at the surgical site, were performed on four patients of both groups. Within the first 2 years after IORT as a boost, therapy-induced changes at the original tumor site are significantly more pronounced compared with a control group. There is no evidence that the interpretation of findings is complicated after IORT.

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Authors and Affiliations

  1. Department of Radiology, University Hospital Mannheim, University of Heidelberg, Heidelberg, Germany

    K. Wasser, C. Schoeber, J. Teubner & W. Neff

  2. Department of Radiation Oncology, Mannheim Medical Center, University of Heidelberg, Heidelberg, Germany

    U. Kraus-Tiefenbacher & F. Wenz

  3. Department of Gynecology and Obstetrics, University Hospital Mannheim, University of Heidelberg, Heidelberg, Germany

    L. Bauer

  4. Department of Statistics, University Hospital Mannheim, University of Heidelberg, Heidelberg, Germany

    J. Brade

  5. Diagnostic Breastcenter St. Elisabethklinik Heidelberg, Heidelberg, Germany

    J. Teubner

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  1. K. Wasser
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  2. C. Schoeber
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  3. U. Kraus-Tiefenbacher
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  4. L. Bauer
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  5. J. Brade
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  6. J. Teubner
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  7. F. Wenz
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  8. W. Neff
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Correspondence to K. Wasser.

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Wasser, K., Schoeber, C., Kraus-Tiefenbacher, U. et al. Early mammographic and sonographic findings after intraoperative radiotherapy (IORT) as a boost in patients with breast cancer. Eur Radiol 17, 1865–1874 (2007). https://doi.org/10.1007/s00330-006-0556-z

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  • DOI: https://doi.org/10.1007/s00330-006-0556-z

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