Abstract
Peripheral nerve tumors are not frequent, but due to their association with a nerve they are somewhat special. They may be encountered incidentally during evaluation of a soft-tissue mass or when a nerve lesion is clinically suspected and the recognition of such a lesion and its differential diagnosis is key for successful therapy and patient prognosis. As sonography is often the first line modality in the work-up of a soft-tissue mass, the sonographer should be aware of the typical features of such lesions in order to arrive at the correct diagnosis, and this article tries to give an overview of the histological subtypes of peripheral nerve tumors and their sonographic characteristics.
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References
Hughes DG, Wilson DJ (1986) Ultrasound appearances of peripheral nerve tumours. Br J Radiol 59:1041–1043
Enzinger FM, Weiss SW (1995) Benign tumors of peripheral nerves. In: Enzinger FM, Weiss SW (eds) Soft tissue tumors, 3rd edn. Mosby, St Louis, pp 821–888
Murphey MD, Smith WS, Smith SE, Kransdorf MJ, Temple HT (1999) From the archives of the AFIP. Imaging of musculoskeletal neurogenic tumors: radiologic-pathologic correlation. Radiographics 19:1253–1280
Enzinger FM, Weiss SW (1995) Malignant tumors of the peripheral nerves. In: Enzinger FM, Weiss SW (eds) Soft tissue tumors, 3rd edn. Mosby, St Louis, pp 889–928
Riccardi VM (1981) Von Recklinghausen neurofibromatosis. New Engl J Med 305:1617–1627
Fornage BD (1988) Peripheral nerves of the extremities: imaging with US. Radiology 167:179–182
Graif M, Seton A, Nerubali J et al (1991) Sciatic nerve: sonographic evaluation and anatomic-pathologic considerations. Radiology 181:405–408
Silvestri E, Martinoli C, Derchi LE et al (1995) Echotexture of peripheral nerves: correlation between US and histologic findings and criteria to differentiate tendons. Radiology 197:291–296
Martinoli C, Bianchi S, Derchi LE (1999) Tendon and nerve sonography. Radiol Clin North Am 37:691–711
Buchberger W, Judmaier W, Birbamer G et al (1992) Carpal tunnel syndrome: diagnosis with high-resolution sonography. AJR Am J Roentgenol 159:793–798
Martinoli C, Serafini G, Bianchi S, Bertolotto M, Gandolfo N, Derchi LE (1996) Ultrasonography of peripheral nerves. J Peripher Nerv Syst 1:169–178
Bodner G, Schocke MF, Rachbauer F, Seppi K, Peer S, Fierlinger A, Sununu T, Jaschke WR (2002) Differentiation of malignant and benign musculoskeletal tumors: combined color and power Doppler US and spectral wave analysis. Radiology 223:410–416
Kiechl S (2003) An introduction to electrodiagnostic testing. In: Peer S, Bodner G (eds) High-resolution sonography of the peripheral nervous system. Springer, Berlin Heidelberg New York, pp 121–134
Gruber H, Kovacs P (2003) Sonographic anatomy of the peripheral nervous system. In: Peer S, Bodner G (eds) High-resolution sonography of the peripheral nervous system. Springer, Berlin Heidelberg New York, pp 13–36
Riede UN, Schaefer HE (1995) Allgemeine und spezielle Pathologie. Thieme, Stuttgart New York
Bacigalupo L, Bianchi S, Valle M et al (2003) Ultraschall peripherer Nerven. Radiologe 43:841–849
Peer S, Bodner G, Meirer R et al (2001) Examination of postoperative peripheral nerve lesions with high-resolution sonography. AJR Am J Roentgenol 177:415–419
Shafighi M, Gurunluoglu R, Ninkovic M et al (2003) Ultrasonography for depiction of brachial plexus injury. J Ultrasound Med 22:631–634
Gruber H, Glodny B, Galiano K, Kamelger F, Bodner G, Hussl H, Peer S (2006) High-resolution ultrasound of the supraclavicular brachial plexus-can it improve therapeutic decisions in patients with plexus trauma? Eur Radiol DOI 10.1007/s00330-006-0464-2
Piza-Katzer H (2003) Clinical considerations: the surgeon’s perspective. In: Peer S, Bodner G (eds) High-resolution sonography of the peripheral nervous system. Springer, Berlin Heidelberg New York, pp 107–120
Bendix N, Wolf C, Gruber H, Bodner G (2005) Ultrasound of tumours and tumour-like lesions of peripheral nerves. Ultraschall Med 26:318–324
Chiou HJ, Chou YH, Chiou SY et al (2003) Peripheral nerve lesions: role of high-resolution ultrasound. Radiographics 23:15e
Gruber H, Kovacs P, Peer S, Frischhut B, Bodner G (2004) Sonographically guided phenol injection in painful stump neuroma. AJR Am J Roentgenol 182:952–954
Beggs I (1999) Sonographic appearances of nerve tumors. J Clin Ultrasound 27:363–368
Redd RA, Peters VJ, Emery SF, Branch HM, Rifkin MD (1989) Morton neuroma: sonographic evaluation. Radiology 171:415–417
Sobiesk GA, Wertheimer SJ, Schulz R et al (1997) Sonographic evaluation of interdigital neuromas. J Foot Ankle Surg 36:364–366
Read JW, Noakes JB, Kerr D et al (1999) Mortons metatarsalgia: sonographic findings and correlated histopathology. Foot Ankle Int 20:153–161
Quinn TJ, Jacobson JA, Craig JG, van Holsbeeck MT (2000) Sonography of Mortons neuromas. AJR Am J Roentgenol 174:1723–1728
Stuart RM, Koh ESC, Breidahl WH (2003) Sonography of peripheral nerve pathology. AJR Am J Roentgenol 182:123
Kline SC, Moore JR (1992) Intraneural hemangioma: a case report of acute cubital tunnel syndrome. J Hand Surg [Am] 17:305–307
Van Meir N, De Smet L (2003) Carpal tunnel syndrome in children. Acta Orthop Belg 69:387–395
Glasker S, Berlis A, Pagenstecher A et al (2005) Characterization of hemangioblastomas of spinal nerves. Neurosurgery 56:503–509
Heilbrun ME, Tsuruda JS, Townsend JJ et al (2001) Intraneural perineurioma of the common peroneal nerve. Case report and review of the literature. J Neurosurg 94:811–815
Reynolds DL, Jacobson JA, Inampudi P et al (2004) Sonographic characteristics of peripheral nerve sheath tumors. AJR Am J Roentgenol 182:741–744
Lin J, Jacobson JA, Hayes CW (1999) Sonographic target sign in neurofibromas. J Ultrasound Med 18:513–517
De Schepper AM (1997) Imaging of soft tissue tumors. Springer, Berlin Heidelberg New York
Hughes MJ, Thomas JM, Fisher C, Moskovic EC (2005) Imaging features of retroperitoneal and pelvic schwannomas. Clin Radiol 60:886–893
Lin J, Martel W (2001) Cross-sectional imaging of peripheral nerve sheath tumors: characteristic signs on CT, MR imaging, and sonography. AJR Am J Roentgenol 176:75–82
Hourani R, Rizk T, Kung S, Boudghene F (2006) Elephantiasis neuromatosa in neurofibromatis type I. MRI findings with review of the literature. J Neuroradiol 33:62–66
Brannon RB, Anand PM (2004) Oral granular cell tumors: an analysis of 10 new pediatric and adolescent cases and a review of the literature. J Clin Pediatr Dent 29:69–74
Porter GJ, Evans AJ, Lee AH, Hamilton LJ, James JJ (2006) Unusual benign breast lesions. Clin Radiol 61:562–569
Adeniran A, Al-Ahmadie H, Mahoney MC, Robinson-Smith TM (2004) Granular cell tumor of the breast: a series of 17 cases and review of the literature. Breast J 10:528–531
Wanebo JE, Malik JM, VandenBerg SR, Wanebo HJ, Driesen N, Persing JA (1993) Malignant peripheral nerve sheath tumors. A clinicopathologic study of 28 cases. Cancer 71:1247–1253
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Gruber, H., Glodny, B., Bendix, N. et al. High-resolution ultrasound of peripheral neurogenic tumors. Eur Radiol 17, 2880–2888 (2007). https://doi.org/10.1007/s00330-007-0645-7
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DOI: https://doi.org/10.1007/s00330-007-0645-7