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Comparative map between the domestic pig and dog

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Abstract

Cross-species chromosome painting with probes derived from flow-sorted dog and human chromosomes was used to construct a high-resolution comparative map for the pig. In total 98 conserved autosomal segments between pig and dog were detected by probes specific for the 38 autosomes and X Chromosome of the dog. Further integration of our results with the published human–dog and cat–dog comparative maps, and with data from comparative gene mapping, increases the resolution of the current pig–human comparative map. It allows for the conserved syntenies detected in the pig, human, and cat to be aligned against the putative ancestral karyotype of eutherian mammals and for the history of karyotype evolution of the pig lineage to be reconstructed. Fifteen fusions, 17 fissions, and 23 inversions are required to convert the ancestral mammalian karyotype into the extant karyotype of the pig.

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Notes

  1. Pig Base, http://www.toulouse.inra.fr/lgc/pig/cyto/cyto.htm.

  2. Dog Map, http://www.recomgen.univ-rennes1.fr/cgi-dog/integrateRHgene.prog.

  3. Human Base in NCBI map http://www.ncbi.nlm.nih.gov/mapview/map-search.cgi?taxid=9606.

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Acknowledgments

This study was funded by the Molecular Cell Biology (MCB) and Russian Fund of Basic Research (RFBR) Research Grants and the Independent International Association (INTAS) Grant 01-2163 to ASG. FY is partly supported by the National Natural Science Foundation of China. We thank Prof. Terence J. Robinson, Stellenbosch University, South Africa, for critical review of the manuscript.

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Novosibirsk, Russia

    L.S. Biltueva, N.V. Vorobieva & A.S. Graphodatsky

  2. Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yuunan, P. R. China

    F. Yang

  3. Department of Clinical Veterinary Medicine, Centre for Veterinary Science, University of Cambridge, Cambridge, United Kingdom

    F. Yang

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  1. L.S. Biltueva
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  2. F. Yang
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  3. N.V. Vorobieva
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  4. A.S. Graphodatsky
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Correspondence to A.S. Graphodatsky.

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Biltueva, L., Yang, F., Vorobieva, N. et al. Comparative map between the domestic pig and dog. Mamm Genome 15, 809–818 (2004). https://doi.org/10.1007/s00335-004-2391-3

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  • DOI: https://doi.org/10.1007/s00335-004-2391-3

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