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Effects of ENU dosage on mouse strains

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Abstract.

The germline supermutagen, N-ethyl-N-nitrosourea (ENU), has a variety of effects on mice. ENU is a toxin and carcinogen as well as a mutagen, and strains differ in their susceptibility to its effects. Therefore, it is necessary to determine an appropriate mutagenic, non-toxic dose of ENU for strains that are to be used in experiments. In order to provide some guidance, we have compiled data from a number of laboratories that have exposed male mice from inbred and non-inbred strains or their F1 hybrids to ENU. The results show that most F1 hybrid animals tolerate ENU well, but that inbred strains of mice vary in their longevity and in their ability to recover fertility after treatment with ENU.

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Authors and Affiliations

  1. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA, US

    Monica J. Justice & John S. Weber

  2. Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA, US

    Don A. Carpenter, Darla Miller, Eugene M. Rinchik, Patricia R. Hunsicker & William L. Russell

  3. GSF-National Research Center for Environment and Health, Neuherberg, Germany, DE

    Jack Favor, Angelika Neuhauser-Klaus, Martin Hrabé de Angelis & Dian Soewarto

  4. Department of Human Oncology, University of Wisconsin, Madison, Wisconsin 53792, USA, US

    Amy Moser

  5. Samuel Lunenfeld Institute, Mount Sinai Hospital, Toronto, Canada, CA

    Sabine Cordes

  6. Roswell Park Cancer Institute, Buffalo, New York, USA, US

    Verne Chapman

  7. Division of Biology, Kansas State University, Manhattan, Kansas 66706, USA, US

    Vernon C. Bode

Authors
  1. Monica J. Justice
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  2. Don A. Carpenter
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  3. Jack Favor
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  4. Angelika Neuhauser-Klaus
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  5. Martin Hrabé de Angelis
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  6. Dian Soewarto
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  7. Amy Moser
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  8. Sabine Cordes
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  9. Darla Miller
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  10. Verne Chapman
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  11. John S. Weber
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  12. Eugene M. Rinchik
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  13. Patricia R. Hunsicker
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  14. William L. Russell
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  15. Vernon C. Bode
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Additional information

Received: 11 February 2000 / Accepted: 11 February 2000

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Justice, M., Carpenter, D., Favor, J. et al. Effects of ENU dosage on mouse strains. Mammalian Genome 11, 484–488 (2000). https://doi.org/10.1007/s003350010094

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  • DOI: https://doi.org/10.1007/s003350010094

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