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Multi-institutional study of risk factors of liver metastasis from colorectal cancer: correlation with CD10 expression

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Background

The risk factors for liver metastasis from colorectal cancer are still unclear. We therefore evaluated the relationships between various clinicopathological factors, including CD10 expression, liver metastasis, and survival, in patients with colorectal cancer.

Methods

Clinicopathological data for 1,025 patients with stage II or III colorectal cancer who underwent curative surgery in four participating hospitals were collected and evaluated. Three pathologists examined focal dedifferentiation, venous invasion, and CD10 expression without knowledge of the clinical outcome.

Results

Univariate analysis showed that pathological T (pT), pathological N (pN), venous invasion, focal dedifferentiation, and CD10 expression were significantly associated with liver metastasis. Multivariate analysis selected pT, pN, and CD10 expression as significant risk factors for liver metastasis. pT, pN and CD10 were also shown by univariate and multivariate analyses to be significantly associated with disease-free survival. The incidence of liver metastasis was 3% in pN0 patients with CD10-negative or pT2 or pT3 tumors and 28% in pN2 patients with CD10-positive or pT4 tumors.

Conclusions

CD10 expression is a significant risk factor for liver metastasis in patients with colorectal cancer and is correlated with prognosis. Patients with a high risk of liver metastasis can be selected on the basis of pT, pN, and CD10 expression.

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Acknowledgments

This work was supported by a Grant-in-Aid for Cancer Research from the Ministry of Health, Labor, and Welfare of Japan.

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Authors and Affiliations

  1. Colorectal Surgery Division, National Cancer Center Hospital, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo, 104-0045, Japan

    Shin Fujita

  2. Clinical Laboratory Division, National Cancer Center Hospital, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo, 104-0045, Japan

    Hirokazu Taniguchi & Tadakazu Shimoda

  3. Department of Pathology, Juntendo University School of Medicine, 1-1 Hongo 2-chome, Bunkyo-ku, Tokyo, 113-8421, Japan

    Takashi Yao

  4. Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan

    Hideki Ueno

  5. Department of Gastroenterological Surgery, Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan

    Takashi Hirai

  6. Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Disease, 1-3-3 Nakamichi, Higashinari-ku, Osaka, 537-8511, Japan

    Masayuki Ohue

Authors
  1. Shin Fujita
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  2. Hirokazu Taniguchi
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  3. Takashi Yao
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  4. Tadakazu Shimoda
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  5. Hideki Ueno
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  6. Takashi Hirai
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  7. Masayuki Ohue
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Correspondence to Shin Fujita.

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Fujita, S., Taniguchi, H., Yao, T. et al. Multi-institutional study of risk factors of liver metastasis from colorectal cancer: correlation with CD10 expression. Int J Colorectal Dis 25, 681–686 (2010). https://doi.org/10.1007/s00384-010-0913-x

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  • DOI: https://doi.org/10.1007/s00384-010-0913-x

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