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Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains

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Abstract

There are numerous observations confirming that microglia expressing major histocompatibility complex (MHC) class II molecules are associated with the central nervous system (CNS) in aging and pathological conditions. In this study, we investigated the distribution of MHC class II-positive microglia in Parkinson's disease (PD) brains. The number of MHC class II-positive microglia in the substantia nigra (SN) and putamen increased as the neuronal degeneration of the SN proceeded. These cells were also ICAM-1 (CD54) and LFA-1 (CD11a) positive. The number of activated microglia not only in the SN and putamen but also in the hippocampus, transentorhinal cortex, cingulate cortex and temporal cortex in PD was significantly higher than that in the normal control. Most activated microglia persisted regardless of the presence or absence of Lewy bodies. They were frequently associated not only with α-synuclein-positive Lewy neurites, but also with TH-16-positive dopaminergic and WH-3-positive serotonergic neurites, as well as MAP-2- and SMI-32-positive neurites. These activated microglia were also positive for TNF-α and interleukin-6, which are known to have a neuroprotective function. We conclude that MHC class II-positive microglia are a sensitive index of neuropathological change and are actively associated with damaged neurons and neurites.

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Authors and Affiliations

  1. Department of Neurology, Okazaki City Hospital, 3-1 Goshoai, Kouryuuji-cho, Okazaki, Aichi, 444-8553, Japan

    Kazuhiro Imamura

  2. Department of Neurology, Nagoya University School of Medicine, Nagoya, Aichi, Japan

    Nozomi Hishikawa

  3. Institute for Comprehensive Medical Science, Fujita Health University, Japan Science and Technology Corporation, Toyoake, Aichi, Japan

    Makoto Sawada & Toshiharu Nagatsu

  4. Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Aichi, Japan

    Mari Yoshida & Yoshio Hashizume

Authors
  1. Kazuhiro Imamura
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  2. Nozomi Hishikawa
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  3. Makoto Sawada
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  4. Toshiharu Nagatsu
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  5. Mari Yoshida
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  6. Yoshio Hashizume
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Correspondence to Kazuhiro Imamura.

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Imamura, K., Hishikawa, N., Sawada, M. et al. Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains. Acta Neuropathol 106, 518–526 (2003). https://doi.org/10.1007/s00401-003-0766-2

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  • DOI: https://doi.org/10.1007/s00401-003-0766-2

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