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Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson’s disease and related neurodegenerative disorders

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Abstract

Oxidative stress including DNA oxidation is implicated in Parkinson’s disease (PD). We postulated that DNA repair enzymes such as 8-oxoguanosine DNA glycosylase (OGG1) are involved in the PD process. We performed immunohistochemical and biochemical studies on brains of patients with PD and those of patients with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) as disease controls, and control subjects. We found higher expression levels of mitochondrial isoforms of OGG1 enzymes in the substantia nigra (SN) in cases of PD. Furthermore, Western blot analysis revealed high OGG1 levels in the SN of the patients with PD. Our results indicate the importance of oxidative stress within the susceptible lesions in the pathogenesis of PD.

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Acknowledgement

The authors thank Dr. Makiko Iijima for the technical assistance.

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Authors and Affiliations

  1. Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan

    Jiro Fukae, Masashi Takanashi, Shin-ichiro Kubo, Hideo Mori, Yoshikuni Mizuno & Nobutaka Hattori

  2. Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

    Ken-ichi Nishioka & Yusaku Nakabeppu

Authors
  1. Jiro Fukae
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  2. Masashi Takanashi
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  3. Shin-ichiro Kubo
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  4. Ken-ichi Nishioka
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  5. Yusaku Nakabeppu
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  6. Hideo Mori
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  7. Yoshikuni Mizuno
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  8. Nobutaka Hattori
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Correspondence to Nobutaka Hattori.

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Fukae, J., Takanashi, M., Kubo, Si. et al. Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson’s disease and related neurodegenerative disorders. Acta Neuropathol 109, 256–262 (2005). https://doi.org/10.1007/s00401-004-0937-9

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  • DOI: https://doi.org/10.1007/s00401-004-0937-9

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