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Animal models of Parkinson’s disease progression

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Abstract

Parkinson’s disease (PD) is a progressive neurodegenerative disorder whose etiology is not understood. This disease occurs both sporadically and through inheritance of single genes, although the familial types are rare. Over the past decade or so, experimental and clinical data suggest that PD could be a multifactorial, neurodegenerative disease that involves strong interactions between the environment and genetic predisposition. Our understanding of the pathophysiology and motor deficits of the disease relies heavily on fundamental research on animal models and the last few years have seen an explosion of toxin-, inflammation-induced and genetically manipulated models. The insight gained from the use of such models has strongly advanced our understanding of the progression and stages of the disease. The models have also aided the development of novel therapies to improve symptomatic management, and they are critical for the development of neuroprotective strategies. This review critically evaluates these in vivo models and the roles they play in mimicking the progression of PD.

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Acknowledgements

This work was supported in part by grants NS41799 (GEM), NS41545 (PS), P50 NS38367 and U54 ES12078 (MFC), and W81XWH-05-1-0580 (USAMRMC NETRP Program to GEM).

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Authors and Affiliations

  1. Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL, 60064, USA

    Gloria E. Meredith

  2. Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ, 08854, USA

    Patricia K. Sonsalla

  3. Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, 300 UCLA Medical Plaza, Suite B200, Los Angeles, CA, 90095-6975, USA

    Marie-Francoise Chesselet

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  1. Gloria E. Meredith
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  2. Patricia K. Sonsalla
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  3. Marie-Francoise Chesselet
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Correspondence to Gloria E. Meredith.

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Meredith, G.E., Sonsalla, P.K. & Chesselet, MF. Animal models of Parkinson’s disease progression. Acta Neuropathol 115, 385–398 (2008). https://doi.org/10.1007/s00401-008-0350-x

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  • DOI: https://doi.org/10.1007/s00401-008-0350-x

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