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Expression and clinical significance of vascular endothelial growth factor, cyclooxygenase-2, and Bcl-2 in borderline ovarian tumors

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Abstract

Objective

The objectives were to study the expression of vascular endothelial growth factor (VEGF), cyclooxygenase-2 (Cox-2), and Bcl-2 in borderline ovarian tumors (BOTs) and the relationship within them, and to investigate the correlation between expression of VEGF, Cox-2, and Bcl-2, and the clinicopathologic features of BOTs.

Methods

An immunohistochemical technique was used to investigate the expression of VEGF ,Cox-2, and Bcl-2 in 69 borderline, 18 benign, and 27 malignant human ovarian tumor tissues.

Results

Expression rate of VEGF protein (59.4%) in BOTs was higher than in benign tumors (27.8%) and was lower than in ovarian carcinomas (92.6%), and there was a significant difference between BOTs and benign ovarian tumors (p<0.05), and carcinoma (p<0.01). Significant correlation was observed between the positive expression rate for VEGF and clinical stage of BOTs (p<0.05). The statistical analysis did not show a close correlation between the expression of VEGF and tissue type, and peritoneal implants in BOTs (p>0.05). The expression rate of Cox-2 was significantly higher in ovarian carcinomas (81.5%) than in BOTs (57.9%) and in benign ovarian tumors (38.9%) (p<0.05). Significant correlation was observed between the positive expression rate for Cox-2 and the clinical stage of BOTs (p<0.05). The statistical analysis showed no close correlation between the expression of Cox-2 and tissue type, and peritoneal implants in BOTs (p>0.05). There was a significant difference between the expression of Bcl-2 in ovarian carcinomas and BOTs than that in benign ovarian tumors (p<0.05). The positive expression rate of Bcl-2 was not related to clinical stages and peritoneal implants (p>0.05). Statistical analysis showed a positive correlation between the expression of Cox-2 and VEGF, and Bcl-2 in BOTs.

Conclusions

Overexpression of VEGF, Cox-2, and Bcl-2 in BOTs may play an important role in the oncogenesis and progression of BOTs. It is feasible to detect VEGF, Cox-2, and Bcl-2 in the diagnosis and to predict the prognosis of BOTs.

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Acknowledgements

This work was supported by the Science Foundation of the Education Department of Gansu (02B3—01).

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Authors and Affiliations

  1. Department of Pathology, Lanzhou Medical College, Lanzhou University, Gansu Province, 730000, People’s Republic of China

    Min Li, Shu-Ying Qi, Yong Wang & Shu-Xian Feng

  2. School of Life Science, Lanzhou University, Gansu Province, 730000, People’s Republic of China

    Bang-Zhi Zhang & Rui Wang

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  1. Min Li
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  2. Shu-Ying Qi
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Correspondence to Rui Wang.

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Li, M., Qi, SY., Wang, Y. et al. Expression and clinical significance of vascular endothelial growth factor, cyclooxygenase-2, and Bcl-2 in borderline ovarian tumors. Arch Gynecol Obstet 272, 48–52 (2005). https://doi.org/10.1007/s00404-004-0708-9

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  • DOI: https://doi.org/10.1007/s00404-004-0708-9

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