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Frontal and temporal volume size of grey and white matter in patients with schizophrenia

An MRI parcellation study

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European Archives of Psychiatry and Clinical Neuroscience Aims and scope Submit manuscript

Abstract

We previously performed a magnetic resonance imaging (MRI) parcellation study that showed smaller grey and white matter volumes of the temporal lobes and increased CSF volumes in the frontal and temporal lobe in men with schizophrenia. One question that arose from this earlier study was whether similar structural changes in the brain are found in a large group of schizophrenic patients consisting of both men and women. In the present study, MRI scans were acquired from 94 patients of both genders with schizophrenia and 101 healthy subjects. After the automatic segmentation of grey matter, white matter, and cerebrospinal fluid, the frontal, temporal, parietal, and occipital lobes were automatically parcellated according to the Talairach atlas. Compared with healthy subjects, schizophrenic patients showed significantly smaller volumes of grey matter in the temporal lobe and white matter in the frontal lobe. Schizophrenic patients had a greater CSF volume in the frontal and temporal lobes. These results suggest that volume reduction in the cerebrum is prominent in the frontal and temporal lobes in both men and women with schizophrenia.

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Acknowledgements

We would like to thank Masato Matsumoto PhD for providing statistical advice. We thank Drs. Göran C. Sedvall, and Erik Jönsson and research nurse Monica Hellberg of the Human Brain Informatics Project, Karolinska Institutet, for providing valuable assistance. The Wallenberg Foundation, Sweden, is acknowledged.

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Correspondence to Gaku Okugawa MD, PhD.

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Okugawa, G., Tamagaki, C. & Agartz, I. Frontal and temporal volume size of grey and white matter in patients with schizophrenia. Eur Arch Psychiatry Clin Neurosc 257, 304–307 (2007). https://doi.org/10.1007/s00406-007-0721-7

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  • DOI: https://doi.org/10.1007/s00406-007-0721-7

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