Abstract
We previously performed a magnetic resonance imaging (MRI) parcellation study that showed smaller grey and white matter volumes of the temporal lobes and increased CSF volumes in the frontal and temporal lobe in men with schizophrenia. One question that arose from this earlier study was whether similar structural changes in the brain are found in a large group of schizophrenic patients consisting of both men and women. In the present study, MRI scans were acquired from 94 patients of both genders with schizophrenia and 101 healthy subjects. After the automatic segmentation of grey matter, white matter, and cerebrospinal fluid, the frontal, temporal, parietal, and occipital lobes were automatically parcellated according to the Talairach atlas. Compared with healthy subjects, schizophrenic patients showed significantly smaller volumes of grey matter in the temporal lobe and white matter in the frontal lobe. Schizophrenic patients had a greater CSF volume in the frontal and temporal lobes. These results suggest that volume reduction in the cerebrum is prominent in the frontal and temporal lobes in both men and women with schizophrenia.
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Agartz I, Okugawa G, Greiz D, Nordström M, Greitz D, Magnotta VA, Sedvall G (2001) Reliability and reproducibility of brain tissue volumetry from segmented MR scans. Eur Arch Psychiatry Clin Neurosci 251:255–261
American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Association Press, Washington, DC
Andreasen NC (1983) Scale for the assessment of negative symptoms (SANS). Iowa City, University of Iowa College of Medicine
Andreasen NC (1984) Scale for the assessment of positive symptoms (SAPS). Iowa City, University of Iowa College of Medicine
Andreasen NC, Cizaldo T, Harris G, Swayze V, O’Leary DS, Cohen G, Ehrhardt J, Yuh WTC (1993) Voxel processing techniques for the antemortemstudy of neuroanatomy and neuropathology using MRI. J Neuropsych Clin Neurosci 5:121–130
Buchanan RW, Vladar KV, Barta PE, Pearlson GD (1998) Structural evaluation of the prefrontal cortex in schizophrenia. Am J Psychiatry 155:1049–1055
Cannon TD, van Erp TG, Huttunen M, Lonnqvist J, Salonen O, Valanne L, Poutanen VP, Standertskjold-Nordenstam CG, Gur RE, Yan M (1998) Regional grey matter, white matter, and cerebrospinal fluid distributions in schizophrenic patients, their siblings, and controls. Arch Gen Psychiatry 55:1084–1091
Chemerinski E, Nopoulos NC, Crespo-Facorro B, Andreasen NC, Magnotta V (2002) Morphology of the ventral frontal cortex in schizophrenia: relationship with social dysfunction. Biol Psychiatr 52:1–8
Flaum M, Swayze VW 2nd, O’Leary DS, Yuh WT, Ehrhardt JC, Arndt SV, Andreasen NC (1995) Effect of diagnosis, laterality and gender on brain morphology in schizophrenia. Am J Psychiatr 152:704–714
Harris G, Andreasen NC, Cizadlo T, Bailey JM, Bockholt HJ, Magnotta VA, Arndt S (1999) Improving tissue classification in MRI: a three-dimensional multispectral discriminant analysis method with automated training class selection. J Comput Assist Tomogr 23:144–154
Kane JM (2003) The expert consensus guideline series optimizing pharmacologic treatment of psychotic disorders. J Clin Psychiatr 64:S12
Magnotta VA, Heckel D, Andreasen NC, Cizadlo T, Corson PW, Ehrhardt JC, Yuh WT (1999) Measurement of brain structures with artificial neural networks: two- and three-dimensional applications. Radiology 211:781–790
Okugawa G, Sedvall GC, Agartz I (2002) Reduced grey and white matter volumes in the temporal lobe of male patients with chronic schizophrenia. Eur Arch Psychiatry Clin Neurosci 252:120–123
Okugawa G, Takase K, Nobuhara K, Yoshida T, Minami T, Tamagaki C, Magnotta VA, Andreasen NC, Kinoshita T (2003) Inter- and intraoperator reliability of brain tissue measures using magnetic resonance imaging. Eur Arch Psychiatry Clin Neurosci 253:301–306
Rector NA, Seeman MV (1992) Auditory hallucinations in women and men. Schizoph Res 7:233–236
Shrout P, Fleiss J (1979) Intraclass correlations: uses in assessing rater reliability. Psychol Bull 86:420–429
Shtasel DL, Gur RE, Gallacher F, Heimberg C, Gur RC (1992) Gender differences in the clinical expression of schizophrenia. Schizophr Res 7:225–231
Talairach J, Tournoux P (1988) Coplanar stereotaxic atlas of human brain. Thieme medical, New York
Acknowledgements
We would like to thank Masato Matsumoto PhD for providing statistical advice. We thank Drs. Göran C. Sedvall, and Erik Jönsson and research nurse Monica Hellberg of the Human Brain Informatics Project, Karolinska Institutet, for providing valuable assistance. The Wallenberg Foundation, Sweden, is acknowledged.
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Okugawa, G., Tamagaki, C. & Agartz, I. Frontal and temporal volume size of grey and white matter in patients with schizophrenia. Eur Arch Psychiatry Clin Neurosc 257, 304–307 (2007). https://doi.org/10.1007/s00406-007-0721-7
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DOI: https://doi.org/10.1007/s00406-007-0721-7