Abstract
Alzheimer’s disease and related dementias are devastating disorders that lead to the progressive decline of cognitive functions. Characteristic features are severe brain atrophy, paralleled by accumulation of beta amyloid and neurofibrillary tangles. With the discovery of neurogenesis in the adult brain, the hopes have risen that these neurodegenerative conditions could be overcome, or at least ameliorated, by the generation of new neurons. The location of the adult neurogenic zones in the hippocampus and the lateral ventricle wall, close to corpus callosum and neocortex, indicates strategic positions for potential repair processes. However, we also need to consider that the generation of new neurons is possibly involved in cognitive functions and could, therefore, be influenced by disease pathology. Moreover, aberrant neurogenic mechanisms could even be a part of the pathological events of neurodegenerative diseases. It is the scope of this review to summarize and analyze the recent data from neurogenesis research with respect to Alzheimer’s disease and its animal models.
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Abbreviations
- AD:
-
Alzheimer’s disease
- APP:
-
amyloid precursor protein
- Aß:
-
beta amyloid peptide
- BDNF:
-
brain derived neurotrophic factor
- BrdU:
-
bromo-deoxyuridine
- CA:
-
cornu ammonis
- CNS:
-
central nervous system
- DCX:
-
doublecortin
- DG:
-
dentate gyrus
- FGF-2:
-
fibroblast growth factor 2
- IGF-1:
-
insulin-like growth factor 1
- LTP:
-
long-term potentiation
- MAP:
-
microtubule-associated protein
- NFT:
-
neurofibrillary tangle
- PCNA:
-
proliferating cell nuclear antigen
- PDGF:
-
platelet-derived growth factor
- PS:
-
presenilin
- RMS:
-
rostral migratory stream
- SGZ:
-
subgranular zone
- SVZ:
-
subventricular zone
- VEGF:
-
vascular endothelial growth factor
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Kuhn, H.G., Cooper-Kuhn, C.M., Boekhoorn, K. et al. Changes in neurogenesis in dementia and Alzheimer mouse models: are they functionally relevant?. Eur Arch Psychiatry Clin Neurosc 257, 281–289 (2007). https://doi.org/10.1007/s00406-007-0732-4
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DOI: https://doi.org/10.1007/s00406-007-0732-4