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Effects of age on ventilatory threshold and peak oxygen uptake normalised for regional skeletal muscle mass in Japanese men and women aged 20–80 years

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Abstract

Ventilatory threshold (VT) is an important predictor of cardiorespiratory fitness, such as peak oxygen uptake \((\dot{V}_{{{\text{O}}_{2} {\text{peak}}}}),\) and is a valuable index of aerobic exercise intensity. However, little is known about the role of skeletal muscle (SM) mass in the age-associated decline of VT. Therefore, the present study was performed to investigate the effects of age on cardiopulmonary fitness normalised for regional SM mass in 1,463 Japanese men and women, and to determine the relevance of VT normalised to SM mass based on age and gender. Total, trunk and thigh SM mass were measured using an ultrasound method, while \(\dot{V}_{{{\text{O}}_{2} {\text{peak}}}}\) and VT were determined during treadmill walking. \(\dot{V}_{{{\text{O}}_{2} {\text{peak}}}}\) was estimated using the predicted maximum heart rate (HR) and the \({\hbox{HR}{\text{--}}\dot{V}_{{{\text{O}}_{2}}}}\) relationship for sub-maximal treadmill walking. There were significant negative correlations between VT normalised for body mass and age in men and women (P <  0.001). Age-associated declines were also observed in VT normalised for body mass in both men and women; however, VT normalised for SM mass was not significantly different with age. Significant correlations were also observed between thigh SM mass and VT in both men and women. These results suggest that thigh SM mass is closely associated with \(\dot{V}_{{{\text{O}}_{2} {\text{peak}}}}\) and/or VT in both men and women, and the decrease in VT with age is predominantly due to an age-related decline of SM mass. Moreover, this study provides normative cardiorespiratory fitness data regarding VT normalised SM mass in healthy men and women aged 20–80 years.

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Authors and Affiliations

  1. Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Wasedatsurumaki-cho, Shinjuku-ku, Tokyo, 162-0041, Japan

    Kiyoshi Sanada

  2. Division of Integrated Humanistic and Cultural Studies, Graduate School of Integrated Science and Art, University of East Asia, Shimonoseki, Japan

    Tsutomu Kuchiki

  3. National Institute of Health and Nutrition, Tokyo, Japan

    Motohiko Miyachi

  4. Department of Physiological Sciences and Sports Performance, National Institute of Fitness and Sports, Kanoya, Japan

    Kelly McGrath

  5. Faculty of Sport Sciences, Waseda University, Tokorozawa, Japan

    Mitsuru Higuchi

  6. Faculty of Integrated Cultures and Humanities, University of East Asia, Shimonoseki, Japan

    Hiroshi Ebashi

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  1. Kiyoshi Sanada
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  2. Tsutomu Kuchiki
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  3. Motohiko Miyachi
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  4. Kelly McGrath
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  5. Mitsuru Higuchi
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  6. Hiroshi Ebashi
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Correspondence to Kiyoshi Sanada.

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Sanada, K., Kuchiki, T., Miyachi, M. et al. Effects of age on ventilatory threshold and peak oxygen uptake normalised for regional skeletal muscle mass in Japanese men and women aged 20–80 years. Eur J Appl Physiol 99, 475–483 (2007). https://doi.org/10.1007/s00421-006-0375-6

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  • DOI: https://doi.org/10.1007/s00421-006-0375-6

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