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Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers

  • The ABC of Solute Carriers
  • Guest Editor: Matthias A. Hediger
  • Published:
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Abstract

All of the members of this family are thought to facilitate zinc efflux from the cytoplasm either into various intracellular compartments (endosomes, secretory granules, synaptic vesicles, Golgi apparatus, or trans-Golgi network) or across the plasma membrane. Thus, these transporters are thought to help maintain zinc homeostasis and facilitate transport of zinc into specialized intracellular compartments. Counterparts of the SLC30 family are found in all organisms. Most of the members of this class are predicted to have 6 transmembrane domains with both N- and C-termini on the cytoplasmic side of the membrane. Expression of rodent Znt1, Znt2 or Znt4 cDNAs in mammalian cells can confer resistance to zinc toxicity. Loss of function of the mouse Znt1 is embryonic lethal, loss of mouse Znt3 prevents accumulation of zinc in synaptic vesicles, nonfunctional mouse Znt4 (lethal milk) results in zinc-deficient milk, and Znt5-null mice display bone abnormalities and heart failure. No mutations in human counterparts of any of the members of the SLC30 family have been described.

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Authors and Affiliations

  1. Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195, USA

    Richard D. Palmiter

  2. Western Human Nutrition Research Center/Agricultural Research Service/United States Department of Agriculture, Department of Nutrition and the Rowe Program in Genetics, University of California, Davis, CA 95616, USA

    Liping Huang

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Correspondence to Richard D. Palmiter.

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Palmiter, R.D., Huang, L. Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers. Pflugers Arch - Eur J Physiol 447, 744–751 (2004). https://doi.org/10.1007/s00424-003-1070-7

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  • DOI: https://doi.org/10.1007/s00424-003-1070-7

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