Abstract
The forkhead domain containing transcription factor BF-1 has been shown to play a major role in the correct development of the cerebral hemispheres in the mouse. BF-1 orthologs have been isolated from zebrafish and the cephalocordate amphioxus. In both species, BF-1 is expressed in the anterior neural tube. In zebrafish zBF-1 expression is restricted to anterior portions of the otic vesicle and to the presumptive telencephalon. In amphioxus AmphiBF-1 is transiently seen in the frontal part of the first somite and, at 3 days of development, in a small number of cells in the cerebral vesicle (cv). The anterior expression of BF-1 in chordates and vertebrates and of slp-1/2 in Drosophila suggests that BF-1 is crucial for an evolutionarily conserved specification of anterior neuronal cell types.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 11 January 1998 / Accepted: 30 May 1998
Rights and permissions
About this article
Cite this article
Toresson, H., Martinez-Barbera, J., Bardsley, A. et al. Conservation of BF-1 expression in amphioxus and zebrafish suggests evolutionary ancestry of anterior cell types that contribute to the vertebrate telencephalon. Dev Gene Evol 208, 431–439 (1998). https://doi.org/10.1007/s004270050200
Issue Date:
DOI: https://doi.org/10.1007/s004270050200