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Sinonasal tubulopapillary low-grade adenocarcinoma. Histopathological, immunohistochemical and ultrastructural features of poorly recognised entity

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Abstract

We present the clinicopathological, histological and immunohistochemical findings of six cases of primary tubulopapillary low-grade adenocarcinoma of the sinonasal tract with ultrastructural examination in one case. Due to its unique features, we believe that primary tubulopapillary low-grade adenocarcinoma of the sinonasal tract represents a tumour entity different from any tumours generally recognised in the sinonasal region. Our cases had an equal sex incidence, with an age range of 44–76 years. The tumour has a tendency to recur, but none of our six patients developed metastases. We feel that it is important to separate this tumour entity from other types of sinonasal adenocarcinomas that exhibit a papillary growth pattern, as they frequently pursue a much more aggressive clinical course than the tumours in this study.

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Acknowledgements

The authors are most grateful to Dr. Mukensnabl for preparing microphotographs. We also appreciate the technical assistance with the electron microscopy of Mr. Dostal.

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Authors and Affiliations

  1. Sikl's Department of Pathology, Laboratore Spec. Diagnostiky Medical Faculty Hospital, Charles University, Alej Svobody 80, 323 18 , Plzen, Czech Republic

    A. Skalova & M. Michal

  2. Department of Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain

    A. Cardesa

  3. Department of Pathology, University of Helsinki, Helsinki, Finland

    I. Leivo

  4. Institute of Clinical Pathology, University Hospital of Zurich, Switzerland

    M. Pfaltz

  5. Department of Pathology, Medical Faculty, Charles University, Hradec Kralove, Czech Republic

    A. Ryska

  6. Department of Histopathology, Royal Devon and Exeter Hospital, Exeter, UK

    R. Simpson

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  1. A. Skalova
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  2. A. Cardesa
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  3. I. Leivo
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  4. M. Pfaltz
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  5. A. Ryska
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  6. R. Simpson
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  7. M. Michal
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Correspondence to M. Michal.

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Skalova, A., Cardesa, A., Leivo, I. et al. Sinonasal tubulopapillary low-grade adenocarcinoma. Histopathological, immunohistochemical and ultrastructural features of poorly recognised entity. Virchows Arch 443, 152–158 (2003). https://doi.org/10.1007/s00428-003-0844-9

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  • DOI: https://doi.org/10.1007/s00428-003-0844-9

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