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NF-kB in development and progression of human cancer

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Abstract

The nuclear factor kB (NF-kB) comprises a family of transcription factors involved in the regulation of a wide variety of biological responses. NF-kB plays a well-known function in the regulation of immune responses and inflammation, but growing evidences support a major role in oncogenesis. NF-kB regulates the expression of genes involved in many processes that play a key role in the development and progression of cancer such as proliferation, migration and apoptosis. Aberrant or constitutive NF-kB activation has been detected in many human malignancies. In recent years, numerous studies have focused on elucidating the functional consequences of NF-kB activation as well as its signaling mechanisms. NF-kB has turned out to be an interesting therapeutic target for treatment of cancer.

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Acknowledgements

Supported by grants FISS 01/1656, FISS PI020227, SAF 2004-05250 and 2002XT00115. X.D. holds a postdoctoral fellowship supported by Department d’Universitats, Recerca i Societat de la Informació, Generalitat de Catalunya (2003RED0018). J.P. holds a research fellowship from the Fondo de Investigaciones Sanitarias, Ministerio de Sanidad y Consumo (BEFI-02/9007). DLL holds a research fellowship from AECC-Catalunya contra el Cancer-Lleida.

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Correspondence to Xavier Matias-Guiu.

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Dolcet, X., Llobet, D., Pallares, J. et al. NF-kB in development and progression of human cancer. Virchows Arch 446, 475–482 (2005). https://doi.org/10.1007/s00428-005-1264-9

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