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Expression of adhesion molecules during normal pregnancy

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Abstract

We review the available information regarding the role of adhesive molecules as potential participants in the complex events of fertilization, embryogenesis, implantation and placentation. Studies that specifically relate to the expression and modulation of adhesive molecules in fertilization, embryogenesis, and implantation have been identified in the literature and by Medline searches. Cell-cell and cell-extracellular matrix interactions play a critical role in various developmental processes and in the cascade of events that lead to implantation and to the normal development of the fetus during pregnancy. Adhesion molecules influence, directly or indirectly, numerous aspects of cell behaviour, cell migration, cell growth, cell survival, cell proliferation, angiogenesis, invasion and metastasis.

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, City Hospital, Birmingham, UK

    J. Pafilis

  2. Department of Physiology, Division of Adhesion Molecules, Ioannina University Medical School, Ioannina, Greece

    J. Pafilis, A. Bakogiannis, G. Dassopoulos & K. Charalabopoulos

  3. Department of Pathology, Ioannina University Medical School, Ioannina, Greece

    A. Batistatou & E. Tsanou

  4. Department of Medicine, Medway Maritime Hospital, Gillingham, Kent, UK

    A. Iliopoulou

  5. Department of Physiology, Clinical Unit, Medical Faculty, University of Ioannina, Ioannina, 45221, Greece

    K. Charalabopoulos

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  1. J. Pafilis
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Correspondence to K. Charalabopoulos.

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Pafilis, J., Batistatou, A., Iliopoulou, A. et al. Expression of adhesion molecules during normal pregnancy. Cell Tissue Res 329, 1–11 (2007). https://doi.org/10.1007/s00441-007-0406-6

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  • DOI: https://doi.org/10.1007/s00441-007-0406-6

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