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Radiation effects on neural precursor cells in the dentate gyrus

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Abstract

Ionizing irradiation is an effective treatment for intracranial tumors but is limited by the potential adverse effects induced in surrounding normal brain. These effects can include cognitive impairments, and whereas the pathogenesis of such injury has not yet been definitively established, it may involve injury to the neurogenic cell population that exists in the dentate subgranular zone (SGZ) of the hippocampus. Understanding the issues surrounding this topic could have a major impact in the management of specific sequelae associated with cranial irradiation. Although radiation is now becoming a useful tool in investigations into the biology of neurogenesis, the perspective of this review is directed more toward the potential relevance of studying radiation and the stem/precursor cell response.

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Authors and Affiliations

  1. Department of Neurological Surgery, San Francisco General Hospital, Bldg. 1, Room 101, 1001 Potrero Avenue, San Francisco, CA 94110-0899, USA

    Marta Andres-Mach, Radoslaw Rola & John R. Fike

  2. Department of Radiation Oncology, University of California, San Francisco, USA

    John R. Fike

  3. Department of Radiology, University of California, San Francisco, USA

    John R. Fike

  4. Department of Neurological Surgery, F. Skubiszewski Medical University, 8 Jaczewskiego Street, Lublin, Poland

    Radoslaw Rola

  5. Department of Physiopathology, Institute of Agricultural Medicine, Lublin, Poland

    Marta Andres-Mach & Radoslaw Rola

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  1. Marta Andres-Mach
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  2. Radoslaw Rola
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  3. John R. Fike
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Correspondence to John R. Fike.

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This work was supported in part by NIH grant R01 NS46051, NASA grant NNJ04HC90G, and NCI Contract 22xs026a.

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Andres-Mach, M., Rola, R. & Fike, J.R. Radiation effects on neural precursor cells in the dentate gyrus. Cell Tissue Res 331, 251–262 (2008). https://doi.org/10.1007/s00441-007-0480-9

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