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Long-term efficacy of low-density lipoprotein apheresis for focal and segmental glomerulosclerosis

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Abstract

Recently, there have been reports on the efficacy of low-density lipoprotein (LDL) apheresis (LDL-A) for focal and segmental glomerulosclerosis (FSGS) in pediatric patients. However, there have been few reports on the long-term efficacy of LDL-A for FSGS in such patients. We report here a case of long-term efficacy of LDL-A for FSGS. The patient was a 13-year-old boy with FSGS who presented with steroid-resistant and cyclosporine-resistant nephrotic syndrome and hyperlipidemia. LDL-A was performed 24 times on one year. Following LDL-A, serum concentrations of LDL, very low-density lipoprotein (VLDL), apoprotein B, and vascular endothelial growth factor significantly decreased, and urinary excretion of protein also decreased. In addition, 3 years after LDL-A, the pathology findings on a second renal biopsy had improved. The patient has been in remission from FSGS for 12 years since LDL-A. These findings suggest that LDL-A may be useful in maintaining long-term remission from pediatric FSGS.

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Authors and Affiliations

  1. Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima City, Fukushima, 960-1295, Japan

    Yukihiko Kawasaki, Sigeo Suzuki, Ayumi Matsumoto, Kei Takano, Kazuhide Suyama, Koichi Hashimoto, Junzo Suzuki, Hitoshi Suzuki & Mitsuaki Hosoya

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  1. Yukihiko Kawasaki
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  2. Sigeo Suzuki
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  3. Ayumi Matsumoto
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  4. Kei Takano
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  5. Kazuhide Suyama
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  6. Koichi Hashimoto
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  7. Junzo Suzuki
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  8. Hitoshi Suzuki
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  9. Mitsuaki Hosoya
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Correspondence to Yukihiko Kawasaki.

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Kawasaki, Y., Suzuki, S., Matsumoto, A. et al. Long-term efficacy of low-density lipoprotein apheresis for focal and segmental glomerulosclerosis. Pediatr Nephrol 22, 889–892 (2007). https://doi.org/10.1007/s00467-006-0426-6

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  • DOI: https://doi.org/10.1007/s00467-006-0426-6

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