Abstract
Monocyte chemoattractant protein-1 (MCP-1) has a pathogenic role in murine lupus nephritis (LN). We recruited 25 pediatric and adolescent systemic lupus erythematosus (SLE) patients from our lupus clinic [13 (52%) patients with LN and 12 (48%) lupus non-nephritis patients] and evaluated their urinary and plasma MCP-1 levels compared to adult and childhood controls. The median age and SLE disease duration of patients were 14.4 and 5.5 years, respectively. LN patients had a higher median renal (p = 0.01) British Isles Lupus Assessment Group (BILAG) index, with a tendency for higher total BILAG scores (p = 0.2). There were significantly increased urinary MCP-1 levels in the LN patients compared to healthy controls (p < 0.001) whose values were significantly higher than lupus non-nephritis children (p< 0.004). Urinary MCP-1 levels correlated well with total BILAG scores (r = 0.82, p = 0.04). There were no differences in plasma MCP-1 levels between SLE patient groups and pediatric controls, although the levels in the childhood controls were elevated compared to those of the adult controls (p < 0.04). These results provide evidence of increased urinary—but not plasma—MCP-1 levels in children with LN, which correlates well with SLE disease activity as measured by the BILAG index.
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Acknowledgments
SM received a grant from the Peel Medical Research Trust to carry out this research and would like to express his gratitude to them.
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None of the authors have any relationships with companies that may have a financial interest in the information contained in the manuscript. There are no financial interests or arrangements with a company whose product was used in a study or is referred to in a manuscript. There are no financial interests of arrangement with a competing company. There are no direct payments to an author(s) from any source for the purpose of writing the manuscript. There are no other financial connections, direct or indirect, or other situations that might raise the question of bias in the work reported or the conclusions, implications, or opinions stated including pertinent commercial or other sources of funding for the individual author(s) or for the associated department(s) or organization(s), personal relationships, or direct academic competition.
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Marks, S.D., Shah, V., Pilkington, C. et al. Urinary monocyte chemoattractant protein-1 correlates with disease activity in lupus nephritis. Pediatr Nephrol 25, 2283–2288 (2010). https://doi.org/10.1007/s00467-010-1605-z
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DOI: https://doi.org/10.1007/s00467-010-1605-z