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Insight in the prediction of chemotherapy-induced nausea

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Supportive Care in Cancer Aims and scope Submit manuscript

Abstract

Purpose

To identify risk factors for chemotherapy-related nausea.

Methods

We examined risk factors for nausea in 1,696 patients from three multicenter studies conducted from 1998 to 2004. All patients were beginning a chemotherapy regimen containing cisplatin, carboplatin, or doxorubicin. Nausea was assessed on a 1–7 scale four times a day for 4 days by diary.

Results

First, average nausea for breast cancer patients receiving doxorubicin (mean = 2.31) was significantly greater than for other patients receiving doxorubicin (mean = 1.82), patients receiving cisplatin (mean = 1.88), and patients receiving carboplatin (mean = 1.45), Ps < 0.01. Second, mean nausea decreased steadily with age, P < 0.0001. Third, patients rating themselves more susceptible to nausea had significantly more nausea (adjusted mean = 2.51) than patients rating themselves less susceptible (adjusted mean = 1.92) and were 2.8 times more likely to experience severe nausea, Ps < 0.0001. Fourth, expected nausea was a significant predictor of average nausea, P = 0.034, but not severe nausea, P = 0.31. Last, no evidence that gender is a significant predictor of nausea in 299 patients with gender neutral cancers, P = 0.35.

Conclusions

Specific patient characteristics, especially younger age and perceived susceptibility to nausea, can help clinicians in the early identification of patients who are more susceptible to treatment-related nausea.

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Authors and Affiliations

  1. University of Rochester Cancer Center Community Clinical Oncology Program Research Base, James P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 704, Rochester, NY, 14642, USA

    Joseph A. Roscoe, Gary R. Morrow, Charles E. Heckler & Bryan D. Pudlo

  2. Medical Psychology Research Unit, School of Psychology, University of Sydney, Sydney, Australia

    Ben Colagiuri

  3. Northwest Community Clinical Oncology Program, Tacoma, WA, USA

    Lauren Colman

  4. Central Illinois CCOP, Decatur Memorial Hospital, Decatur, IL, USA

    Karen Hoelzer

  5. Virginia Mason CCOP, Seattle, WA, USA

    Andrew Jacobs

  6. University of Rochester, 601 Elmwood Avenue, Box 704, Rochester, NY, 14642, USA

    Joseph A. Roscoe

Authors
  1. Joseph A. Roscoe
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  2. Gary R. Morrow
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  3. Ben Colagiuri
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  4. Charles E. Heckler
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  5. Bryan D. Pudlo
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  6. Lauren Colman
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  7. Karen Hoelzer
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  8. Andrew Jacobs
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Corresponding author

Correspondence to Joseph A. Roscoe.

Additional information

This work was supported by grant number 1R25-CA102618-01A1 from the National Cancer Institute.

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Roscoe, J.A., Morrow, G.R., Colagiuri, B. et al. Insight in the prediction of chemotherapy-induced nausea. Support Care Cancer 18, 869–876 (2010). https://doi.org/10.1007/s00520-009-0723-2

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  • DOI: https://doi.org/10.1007/s00520-009-0723-2

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