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Prevalence of functional dyspepsia in an outpatient clinic with primary care physicians in Japan

  • Original Article—Alimentary Tract
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Abstract

Background

Since little is known about the prevalence of patients with functional gastrointestinal disorders (FGID), this study was performed to clarify the prevalence of FGID, especially functional dyspepsia (FD), in new patients of an outpatient clinic with primary care physicians in Japan.

Methods

We analyzed consecutive outpatients (n = 5183) who first visited the Department of General Medicine, Asahikawa Medical College Hospital, between April 2004 and March 2009.

Results

Out of 5813 patients, 818 (14.1%) visited because of abdominal symptoms. Final diagnoses of the 818 patients were FGID (n = 320, 39.1%), organic gastrointestinal diseases (n = 237, 28.9%), organic non-GI disease (n = 135, 16.5%), and others (n = 126, 15.4%). The 320 patients with FGID had FD (n = 170), irritable bowel syndrome (IBS) (n = 68), and other FGIDs (n = 88). The rate of FGID or FD in all patients was 5.5% or 2.9%, respectively. Among outpatients (n = 381) who complained of upper abdominal symptoms, approximately 45% had FD. There was no gender difference in the frequency of FGID, FD, or IBS in all ages of patients. A lower incidence of FD was shown in female patients over 70 years old and a higher incidence of IBS in male patients under 29 years old.

Discussion

These results suggest that the prevalence of FGID, especially FD, is very high in an outpatient clinic with primary care physicians in Japan.

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References

  1. Drossman DA. The functional gastrointestinal disorders and the Rome III. Gastroenterology. 2006;130:1377–90.

    Article  PubMed  Google Scholar 

  2. Switz DM. What the gastroenterologist does all day. A survey of a state society’s practice. Gastroenterology. 1976;70:1048–50.

    CAS  PubMed  Google Scholar 

  3. Mitchell CM, Drossman DA. Survey of the AGA membership relating to patients with functional gastrointestinal disorders. Gastroenterology. 1987;92:1282–4.

    CAS  PubMed  Google Scholar 

  4. Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada JR, et al. Functional gastroduodenal disorders. Gastroenterology. 2006;130:1466–79.

    Article  PubMed  Google Scholar 

  5. Koloski NA, Talley NJ, Boyce PM. The impact of functional gastrointestinal disorders on quality of life. Am J Gastroenterol. 2000;95:67–71.

    Article  CAS  PubMed  Google Scholar 

  6. Talley NJ, McNeil D, Hayden A, Colreavy C, Piper DW. Prognosis of chronic unexplained dyspepsia. A prospective study of potential predictor variables in patients with endoscopically diagnosed nonulcer dyspepsia. Gastroenterology. 1987;92:1060–6.

    CAS  PubMed  Google Scholar 

  7. Koloski NA, Talley NJ, Boyce PM. Predictors of health care seeking for irritable bowel syndrome and nonulcer dyspepsia: a critical review of the literature on symptom and psychosocial factors. Am J Gastroenterol. 2001;96:1340–9.

    Article  CAS  PubMed  Google Scholar 

  8. Talley NJ, Boyce P, Jones M. Dyspepsia and health care seeking in a community: how important are psychological factors? Dig Dis Sci. 1998;43:1016–22.

    Article  CAS  PubMed  Google Scholar 

  9. International Classification of Diseases 10th edition (ICD-10) codes. International statistical classification of diseases and related health problems, 10th revision, Version for 2007. http://www.who.int/classifications/apps/icd/icd10online/.

  10. Namiki M. Acute ulceration, acute gastric mucosal lesions (AGML) and acute duodenal mucosal lesions (ADML). Nippon Rinsho. 1984;42:40–2.

    CAS  PubMed  Google Scholar 

  11. Yakabi K, Nakamura T. Acute gastroduodenal mucosal lesion. Nippon Rinsho. 1998;56:2336–42.

    CAS  PubMed  Google Scholar 

  12. Colin-Jones DG, Bloom B, Bodemar G, Crean G, Freston J, Gugier R, et al. Management of dyspepsia: report of a working party. Lancet. 1988;1:576–9.

    Google Scholar 

  13. Barbara L, Camilleri M, Corinaldesi R, Crean GP, Heading RC, Johnson AG, et al. Definition and investigation of dyspepsia. Consensus of an international ad hoc working party. Dig Dis Sci. 1989;34:1272–6.

    Article  CAS  PubMed  Google Scholar 

  14. Talley NJ, Colin-Jones D, Koch KL, Koch M, Nyren O, Stanghellini V. Functional dyspepsia: a classification with guidelines for diagnosis and management. Gastroenterol Int. 1991;4:145–60.

    Google Scholar 

  15. Talley NJ, Stanghellini V, Heading RC, Koch KL, Malagelada JR, Tytgat GN. Functional gastroduodenal disorders. Gut. 1999;45(Suppl. 2):II37–42.

    PubMed  Google Scholar 

  16. Bytzer P, Talley NJ. Dyspepsia. Ann Intern Med. 2001;134:815–22.

    CAS  PubMed  Google Scholar 

  17. Bernersen B, Johnsen R, Straume B, Burhol PG, Jenssen TG, Stakkevold PA. Towards a true prevalence of peptic ulcer: the Sorreisa gastrointestinal disorder study. Gut. 1990;31:989–92.

    Article  CAS  PubMed  Google Scholar 

  18. Bernersen B, Johnsen R, Straume B. Non-ulcer dyspepsia and peptic ulcer: the distribution in a population and their relation to risk factors. Gut. 1996;38:822–5.

    Article  CAS  PubMed  Google Scholar 

  19. Johnsen R, Straume B, Forde OH. Peptic ulcer and non-ulcer dyspepsia—a disease and a disorder. Scand J Prim Health Care. 1988;6:239–43.

    Article  CAS  PubMed  Google Scholar 

  20. Westbrook JI, Talley NJ. Empiric clustering of dyspepsia into symptom subgroups: a population-based study. Scand J Gastroenterol. 2002;37:917–23.

    Article  CAS  PubMed  Google Scholar 

  21. Moayyedi P, Forman D, Braunholtz D, Feltbower R, Crocombe W, Liptrott M, et al. The proportion of upper gastrointestinal symptoms in the community associated with Helicobacter pylori, lifestyle factors, and nonsteroidal anti-inflammatory drugs. Leeds HELP study group. Am J Gastroenterol. 2000;95:1448–55.

    Article  CAS  PubMed  Google Scholar 

  22. Halder SL, Locke GR 3rd, Schleck CD, Zinsmeister AR, Melton LJ 3rd, Talley NJ. Natural history of functional gastrointestinal disorders: a 12-year longitudinal population-based study. Gastroenterology. 2007;133:799–807.

    Article  PubMed  Google Scholar 

  23. El-Serag HB, Talley NJ. Systematic review: the prevalence and clinical course of functional dyspepsia. Aliment Pharmacol Ther. 2004;19:643–54.

    Article  CAS  PubMed  Google Scholar 

  24. Jones R, Lydeard S. Prevalence of symptoms of dyspepsia in the community. BMJ. 1989;298:30–2.

    Article  CAS  PubMed  Google Scholar 

  25. Talley NJ, Zinsmeister AR, Schleck CD, Melton LJ 3rd. Dyspepsia and dyspepsia subgroups: a population-based study. Gastroenterology. 1992;102:1259–68.

    CAS  PubMed  Google Scholar 

  26. Koloski NA, Talley NJ, Boyce PM. Epidemiology and health care seeking in the functional GI disorders: a population-based study. Am J Gastroenterol. 2002;97:2290–9.

    Article  PubMed  Google Scholar 

  27. Russo MW, Gaynes BN, Drossman DA. A national survey of practice patterns of gastroenterologists with comparison to the past two decades. J Clin Gastroenterol. 1999;29:339–43.

    Article  CAS  PubMed  Google Scholar 

  28. Klauser AG, Voderholzer WA, Knesewitsch PA, Schindlbeck NE, Müller-Lissner SA. What is behind dyspepsia? Dig Dis Sci. 1993;38:147–54.

    Article  CAS  PubMed  Google Scholar 

  29. Johnsen R, Bernersen B, Straume B, Førde OH, Bostad L, Burhol PG. Prevalences of endoscopic and histological findings in subjects with and without dyspepsia. BMJ. 1991;302:749–52.

    Article  CAS  PubMed  Google Scholar 

  30. Talley NJ, Silverstein MD, Agréus L, Nyrén O, Sonnenberg A, Holtmann G. AGA technical review: evaluation of dyspepsia. American Gastroenterological Association. Gastroenterology. 1998;114:582–95.

    Article  CAS  PubMed  Google Scholar 

  31. Allison MC, Howatson AG, Torrance CJ, Lee FD, Rusell RI. Gastrointestinal damage associated with the use of nonsteroidal anti-inflammatory drugs. N Engl J Med. 1992;327:749–54.

    Article  CAS  PubMed  Google Scholar 

  32. Hollenz M, Stolte M, Leodolter A, Labenz J. NSAID-associated dyspepsia and ulcers: a prospective cohort study in primary care. Dig Dis. 2006;24:189–94.

    Article  PubMed  Google Scholar 

  33. Geeraerts B, Tack J. Functional dyspepsia: past, present, and future. J Gastroenterol. 2008;43:251–5.

    Article  PubMed  Google Scholar 

  34. Drossman DA, Whitehead WE, Camilleri M. Irritable bowel syndrome: a technical review for practice guideline development. Gastroenterology. 1997;112:2120–37.

    Article  CAS  PubMed  Google Scholar 

  35. Thompson WG, Heaton KW, Smyth GT, Smyth C. Irritable bowel syndrome in general practice: prevalence, characteristics, and referral. Gut. 2000;46:78–82.

    Article  CAS  PubMed  Google Scholar 

  36. Itasaka T, Takahashi T. The epidemiological investigation for irritable bowel syndrome using a group examination. Ther Res. 1996;17:4059–64.

    Google Scholar 

  37. Shinozaki M, Fukudo S, Hongo M, Shimosegawa T, Sasaki D, Matsueda K, et al. High prevalence of irritable bowel syndrome in medical outpatients in Japan. J Clin Gastroenterol. 2008;42:1010–6.

    Article  PubMed  Google Scholar 

  38. Drossman DA, Li Z, Andruzzi E, Temple RD, Talley NJ, Thompson WG, et al. U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact. Dig Dis Sci. 1993;38:1569–80.

    Article  CAS  PubMed  Google Scholar 

  39. Agréus L, Svärdsudd K, Nyrén O, Tibblin G. The epidemiology of abdominal symptoms: prevalence and demographic characteristics in a Swedish adult population. A report from the abdominal symptom study. Scand J Gastroenterol. 1994;29:102–9.

    Article  PubMed  Google Scholar 

  40. Kay L, Jørgensen T. Epidemiology of upper dyspepsia in a random population. Prevalence, incidence, natural history, and risk factors. Scand J Gastroenterol. 1994;29:2–6.

    Article  CAS  PubMed  Google Scholar 

  41. Chang L, Toner BB, Fukudo S, Guthrie E, Locke GR, Norton NJ, et al. Gender, age, society, culture, and the patient’s perspective in the functional gastrointestinal disorders. Gastroenterology. 2006;130:1435–46.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

We would like to thank Dr. Y. Saijo (Department of Health Science, Asahikawa Medical College, Japan) for assistance with the statistical analysis.

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Authors and Affiliations

  1. Department of General Medicine, Asahikawa Medical College, 2-1-1 Midorigaoka-Higashi, Asahikawa, 078-8510, Japan

    Toshikatsu Okumura, Sachie Tanno, Masumi Ohhira & Satoshi Tanno

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  1. Toshikatsu Okumura
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  2. Sachie Tanno
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  3. Masumi Ohhira
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  4. Satoshi Tanno
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Correspondence to Toshikatsu Okumura.

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Okumura, T., Tanno, S., Ohhira, M. et al. Prevalence of functional dyspepsia in an outpatient clinic with primary care physicians in Japan. J Gastroenterol 45, 187–194 (2010). https://doi.org/10.1007/s00535-009-0168-x

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  • DOI: https://doi.org/10.1007/s00535-009-0168-x

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