Skip to main content
SpringerLink
Log in

Retrospective Analysis of Predictive Factors for Recurrence After Curatively Resected Papillary Thyroid Carcinoma

  • Published:
Surgery Today Aims and scope Submit manuscript

Abstract

Purpose

This retrospective study analyzes the predictive factors after curative surgery for papillary thyroid carcinoma (PTC).

Methods

We analyzed 386 patients who underwent a curative operation for PTC in our hospital between 1977 and 1997, subject to the inclusion criteria.

Results

According to univariate analysis, pathological lateral cervical lymph node involvement (P < 0.0001), dedifferentiation of the tumor (P < 0.002), male sex (P < 0.0001), a large tumor (P < 0.005), and an age of over 50 years (P < 0.05) were significant factors. Cox’s proportional hazard model showed that a man (P < 0.05), aged over 50 years (P < 0.05), who had a large primary tumor (P < 0.05) with dedifferentiation (P < 0.05), and pathological lateral cervical lymph node metastasis (P < 0.005) was more likely to have recurrence of PTC.

Conclusions

Determining whether lymph node metastasis exists could be useful for predicting recurrence in patients who have undergone curative resection of PTC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. FD Gilliland WC Hunt DM Morris CR Key (1997) ArticleTitlePrognostic factors for thyroid carcinoma Cancer 79 564–73 Occurrence Handle10.1002/(SICI)1097-0142(19970201)79:3<564::AID-CNCR20>3.0.CO;2-0 Occurrence Handle9028369

    Article  PubMed  Google Scholar 

  2. RW Tsang JD Brierley WJ Simpson T Panzarella MK Gospodarowicz SB Sutcliffe (1998) ArticleTitleThe effects of surgery, radioiodine, and external radiation therapy on the clinical outcome of patients with differentiated thyroid carcinoma Cancer 82 375–88 Occurrence Handle10.1002/(SICI)1097-0142(19980115)82:2<389::AID-CNCR19>3.0.CO;2-V Occurrence Handle9445196

    Article  PubMed  Google Scholar 

  3. M Noguchi H Yamada N Ohta T Ishida K Tajiri H Fujii et al. (1987) ArticleTitleRegional lymph node metastases in well-differentiated thyroid carcinoma Int Surg 72 100–3 Occurrence Handle3610534

    PubMed  Google Scholar 

  4. E Mirallie J Visset C Sagan A Hamy M-F Le Bodic J Paineau (1999) ArticleTitleLocalization of cervical node metastasis of papillary thyroid carcinoma World J Surg 23 970–4 Occurrence Handle10.1007/s002689900609 Occurrence Handle10449830

    Article  PubMed  Google Scholar 

  5. N Sato M Oyamatsu Y Koyama I Emura Y Tamiya K Hatakeyama (1998) ArticleTitleDo the level of nodal disease according to the TNM classification and the number of involved cervical nodes reflect prognosis in patients with differentiated carcinoma of the thyroid gland? J Surg Oncol 69 151–5 Occurrence Handle10.1002/(SICI)1096-9098(199811)69:3<151::AID-JSO6>3.0.CO;2-V Occurrence Handle9846501

    Article  PubMed  Google Scholar 

  6. EL Mazzaferri SM Jhiang (1994) ArticleTitleLong-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer Am J Med 97 418–28 Occurrence Handle10.1016/0002-9343(94)90321-2 Occurrence Handle7977430

    Article  PubMed  Google Scholar 

  7. CJ Hughes AR Shaha JP Shah TR Loree (1996) ArticleTitleImpact of lymph node metastasis in differentiated carcinoma of the thyroid: a matched-pair analysis Head Neck 18 127–32 Occurrence Handle10.1002/(SICI)1097-0347(199603/04)18:2<127::AID-HED3>3.0.CO;2-3 Occurrence Handle8647677

    Article  PubMed  Google Scholar 

  8. M Ducci M Apperecchia M Marzetti (1997) ArticleTitleNeck dissection for surgical treatment of lymph node metastasis in papillary thyroid carcinoma J Exp Clin Cancer Res 16 333–5 Occurrence Handle9387910

    PubMed  Google Scholar 

  9. DS Dean ID Hay (2000) ArticleTitlePrognostic indicators in differentiated thyroid carcinoma Cancer Control 7 229–39 Occurrence Handle10832109

    PubMed  Google Scholar 

  10. SI Sherman JD Brierley M Sperling KB Ain ST Bigos DS Cooper et al. (1998) ArticleTitleProspective multicenter study of thyroid carcinoma treatment Cancer 83 1012–21 Occurrence Handle10.1002/(SICI)1097-0142(19980901)83:5<1012::AID-CNCR28>3.0.CO;2-9 Occurrence Handle9731906

    Article  PubMed  Google Scholar 

  11. K Tanaka H Sonoo Y Yamamoto K Udagawa I Arime H Kunisue et al. (1999) ArticleTitleAnalyses of the outcome of locally invasive papillary thyroid carcinomas Thyroid 9 1017–22 Occurrence Handle10560957

    PubMed  Google Scholar 

  12. R Bellantone CP Lombardi M Boscherini A Ferrante M Raffaelli F Rubino et al. (1998) ArticleTitlePrognostic factors in differentiated thyroid carcinoma: a multivariate analysis of 234 consecutive patients J Surg Oncol 68 237–41 Occurrence Handle10.1002/(SICI)1096-9098(199808)68:4<237::AID-JSO6>3.0.CO;2-5 Occurrence Handle9721709

    Article  PubMed  Google Scholar 

  13. CR McHenry IB Rosen PG Walfish (1991) ArticleTitleProspective management of nodal metastases in differentiated thyroid cancer Am J Surg 162 353–6 Occurrence Handle10.1016/0002-9610(91)90147-6 Occurrence Handle1951888

    Article  PubMed  Google Scholar 

  14. JD Lin MJ Liou TC Chao HF Weng YS Ho (1999) ArticleTitlePrognostic variables of papillary and follicular thyroid carcinoma patients with lymph node metastases and without distant metastases Endocrine-Related Cancer 6 109–15 Occurrence Handle10.1677/erc.0.0060109 Occurrence Handle10732793

    Article  PubMed  Google Scholar 

  15. I Tzavara B Vlassopoulou C Alevizaki G Koukoulis M Tzanela P Koumoussi et al. (1999) ArticleTitleDifferentiated thyroid cancer: a retrospective analysis of 832 cases from Greece Clin Endocrinol 50 643–54 Occurrence Handle10.1046/j.1365-2265.1999.00715.x

    Article  Google Scholar 

  16. CG Thomas (1991) ArticleTitleRole of thyroid stimulating hormone suppression in the management of thyroid cancer Semin Surg Oncol 7 115–9 Occurrence Handle2034937

    PubMed  Google Scholar 

  17. M Noguchi H Yagi M Earashi K Kinoshita I Miyazaki Y Mizukami (1995) ArticleTitleRecurrence and mortality in patients with differentiated thyroid carcinoma Int Surg 80 162–6 Occurrence Handle8530235

    PubMed  Google Scholar 

  18. MC Coburn HJ Wanebo (1992) ArticleTitlePrognostic factors and management considerations in patients with cervical metastases of thyroid cancer Am J Surg 164 671–6 Occurrence Handle1463122

    PubMed  Google Scholar 

  19. J Harwood OH Clark JE Dunphy (1978) ArticleTitleSignificance of lymph node metastasis in differentiated thyroid cancer Am J Surg 136 107–12 Occurrence Handle10.1016/0002-9610(78)90209-X Occurrence Handle567016

    Article  PubMed  Google Scholar 

  20. K Sugino Y Kure H Iwasaki O Ozaki T Mimura A Matsumoto et al. (1995) ArticleTitleMetastases to the regional lymph nodes, lymph node recurrence, and distant metastases in nonadvanced papillary thyroid carcinoma Surg Today 25 324–8 Occurrence Handle10.1007/BF00311254 Occurrence Handle7633123

    Article  PubMed  Google Scholar 

  21. A Tsuchiya S Suzuki M Kanno Y Kikuchi Y Ando R Abe (1995) ArticleTitlePrognostic factors associated with differentiated thyroid cancer Surg Today 25 778–82 Occurrence Handle10.1007/BF00311452 Occurrence Handle8555694

    Article  PubMed  Google Scholar 

  22. H Yamashita S Noguchi H Yamashita N Murakami S Watanabe S Uchino et al. (1998) ArticleTitleChanging trends and prognoses for patients with papillary thyroid cancer Arch Surg 133 1058–65 Occurrence Handle10.1001/archsurg.133.10.1058 Occurrence Handle9790201

    Article  PubMed  Google Scholar 

  23. OH Clark (1982) ArticleTitleTotal thyroidectomy Ann Surg 196 361–70 Occurrence Handle7114941

    PubMed  Google Scholar 

  24. H Wanebo M Coburn D Teates B Cole (1998) ArticleTitleTotal thyroidectomy does not enhance disease control or survival even in high-risk patients with differentiated thyroid cancer Ann Surg 227 912–21 Occurrence Handle10.1097/00000658-199806000-00015 Occurrence Handle9637555

    Article  PubMed  Google Scholar 

  25. H Lerch O Schober T Kuwert H-B. Saur (1997) ArticleTitleSurvival of differentiated thyroid carcinoma studied in 500 patients J Clin Oncol 15 2067–75 Occurrence Handle9164219

    PubMed  Google Scholar 

  26. S Noguchi N Murakami H Yamashita M Toda H Kawamoto (1998) ArticleTitlePapillary thyroid carcinoma. Modified radical neck dissection improves prognosis Arch Surg 133 276–80 Occurrence Handle10.1001/archsurg.133.3.276 Occurrence Handle9517740

    Article  PubMed  Google Scholar 

  27. E Mirallie C Sagan A Hamy J Paineau X Kahn JC Le Neel (1999) ArticleTitlePredictive factors for node involvement in papillary thyroid carcinoma. Univariate and multivariate analysis Eur J Cancer 35 420–3 Occurrence Handle10.1016/S0959-8049(98)00399-2 Occurrence Handle10448293

    Article  PubMed  Google Scholar 

  28. PR Kelemen AJ Van Herle AE Giuliano (1998) ArticleTitleSentinel lymphadenectomy in thyroid malignant neoplasms Arch Surg 133 288–92 Occurrence Handle10.1001/archsurg.133.3.288 Occurrence Handle9517742

    Article  PubMed  Google Scholar 

  29. Y Fukui T Yamakawa T Taniki S Numoto H Miki Y Monden (2001) ArticleTitleSentinel lymph node biopsy in patients with papillary thyroid carcinoma Cancer 92 2868–74 Occurrence Handle10.1002/1097-0142(20011201)92:11<2868::AID-CNCR10129>3.0.CO;2-I Occurrence Handle11753960

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Breast and Thyroid Surgery, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192, Japan

    Katsuhiro Tanaka, Hiroshi Sonoo, Mai Hirono, Sumiko Ohkubo, Tsunehisa Nomura, Masahiko Ikeda, Kazukata Nakajima & Junichi Kurebayashi

Authors
  1. Katsuhiro Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hiroshi Sonoo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mai Hirono
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sumiko Ohkubo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tsunehisa Nomura
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Masahiko Ikeda
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Kazukata Nakajima
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Junichi Kurebayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tanaka, K., Sonoo, H., Hirono, M. et al. Retrospective Analysis of Predictive Factors for Recurrence After Curatively Resected Papillary Thyroid Carcinoma. Surg Today 35, 714–719 (2005). https://doi.org/10.1007/s00595-005-3021-8

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00595-005-3021-8

Key words

Search

Navigation