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TNF alpha affects the expression of GFAP and S100B: implications for Alzheimer’s disease

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Summary.

Neurodegenerative disorders such as Alzheimer’s disease are characterized by increased intracellular and extracellular concentrations of the astrocytic proteins glial fibrillary acidic protein (GFAP) and S100B. The present study examined the potential contribution of tumor necrosis factor alpha (TNFα) to these changes by measuring astrocyte viability along with the intracellular and extracellular expression of GFAP and S100B following exposure to this cytokine. Although TNFα did not affect astrocyte viability, the extracellular levels of both proteins were increased three-fold with associated reductions in immunocytochemical labeling.

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Abbreviations

AD:

Alzheimer’s disease

AC:

ammonium citrate

BSA:

bovine serum albumin

DMEM:

Dulbeccos Modified Eagle Medium

FBS:

fetal bovine serum

GFAP:

glial fibrillary acidic protein

LDH:

lactate dehydrogenase

PB:

phosphate buffer

PBS:

phosphate buffered saline

TNFα:

tumor necrosis factor alpha

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Present address: The Jackson Laboratory, 600 Main St., Bar Harbor, ME 04609, USA

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Edwards, M., Robinson, S. TNF alpha affects the expression of GFAP and S100B: implications for Alzheimer’s disease. J Neural Transm 113, 1709–1715 (2006). https://doi.org/10.1007/s00702-006-0479-5

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