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Proposal for genetic characterisation of wild-type mumps strains: Preliminary standardisation of the nomenclature

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Summary.

Though mumps virus (MuV) is a monotypic virus, genetic variation between strains has been described. Viruses have been placed into genotypes designated A–L based on the nucleotide sequence of the small hydrophobic (SH) gene, which is the most variable gene in the mumps genome. Molecular characterisation of MuV is an important component of mumps surveillance because it can help identify the transmission pathways of the virus as well as distinguish between wild-type and vaccine strains. Here, we propose a standardized nomenclature and an analysis protocol for the genetic characterisation of mumps strains to facilitate expansion of molecular epidemiological studies. In addition to assigning standard reference strains for the recognized genotypes of MuV, a convention is proposed for naming for strains and criteria to designate a new genotype.

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Authors and Affiliations

  1. Virus Reference Department, Centre for Infections, Health Protection Agency, London, U.K.

    L. Jin & D. Brown

  2. Medical Biology Centre, The Queen’s University of Belfast, Belfast, U.K.

    B. Rima

  3. Division of Clinical Virology, Huddinge University Hospital, Stockholm, Sweden

    C. Örvell & T. Tecle

  4. Division of Virology, National Institute for Biological Standards and Control, Potters Bar, U.K.

    M. Afzal

  5. Virus Division, Saitama Institute of Public Health, Saitama, Japan

    K. Uchida

  6. Laboratory of Viral Infection, Kitasato Institute for Life Sciences, Tokyo, Japan

    T. Nakayama

  7. Department of Microbiology, Institute for Viral Diseases, College of Medicine, Korea University, Seoul, South Korea

    J.-W. Song

  8. Laboratory of Respiratory Viruses, National Institute of Health, Seoul, South Korea

    C. Kang

  9. Measles Section, Centers for Disease Control and Prevention, Atlanta, U.S.A.

    P. A. Rota

  10. National Laboratory for Measles, Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China

    W. Xu

  11. Department of Immunisation, Vaccines and Biologicals, World Health Organization, Geneva, Switzerland

    D. Featherstone

Authors
  1. L. Jin
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  2. B. Rima
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  3. D. Brown
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  4. C. Örvell
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  5. T. Tecle
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  6. M. Afzal
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  7. K. Uchida
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  8. T. Nakayama
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  9. J.-W. Song
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  10. C. Kang
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  11. P. A. Rota
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  12. W. Xu
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  13. D. Featherstone
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Jin, L., Rima, B., Brown, D. et al. Proposal for genetic characterisation of wild-type mumps strains: Preliminary standardisation of the nomenclature. Arch Virol 150, 1903–1909 (2005). https://doi.org/10.1007/s00705-005-0563-4

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  • DOI: https://doi.org/10.1007/s00705-005-0563-4

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