Original articleCorrelation between inflammatory cytokines released from the lumbar facet joint tissue and symptoms in degenerative lumbar spinal disorders
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Controlled immobilization-traction based on intervertebral stability is conducive to the regeneration or repair of the degenerative disc: an in vivo study on the rat coccygeal model
2019, Spine JournalCitation Excerpt :Previous clinical studies have confirmed that height loss of a degenerative IVD may affect the function of articular processes [40–42]. These processes are accompanied by a narrow joint space, poor joint faces, hyperplasia of the joint, and instability of the spine [40–42]. In addition, instability can lead to accelerated disc degeneration, which can lead to pain and neurologic dysfunction [13].
Physiologic facet capsule stretch can induce pain & upregulate matrix metalloproteinase-3 in the dorsal root ganglia when preceded by a physiological mechanical or nonpainful chemical exposure
2019, Clinical BiomechanicsCitation Excerpt :Although neither NGF nor MMP-3 expression in the DRG were evaluated as a result of either a single subthreshold injection of FJD, each condition was selected as conditions not inducing pain and since the DRG responses follow pain (Figs. 4 and 5), they are not expected to be elevated at day 7 after a single exposure alone. Painful joint loading and aging initiates repair and remodeling of the tissue ECM (Igarashi et al., 2007). Since MMPs mediate ECM remodeling, their increase is a hallmark of early joint degeneration (Bobacz et al., 2003; Chen et al., 2014; Chu et al., 2015; Fujita et al., 2006).
Effect of Pulsed Radiofrequency Therapy on Chronic Refractory Atlanto-Occipital Joint Pain
2018, World NeurosurgeryCitation Excerpt :In addition, electric fields induced by PRF have anti-inflammatory effects. Previous studies by Igarashi et al.21 and Sluijter et al.18 demonstrated that PRF stimulation reduced the levels of inflammatory cytokines, such as interleukin-1β, tumor necrosis factor-α, and interleukin-6. Several studies reported that intra-articular PRF reduced serum C-reactive protein and cytokine levels.18,22,23
Cytokine and chemokine profile changes in patients with lower segment lumbar degenerative spondylolisthesis
2017, International Journal of SurgeryCitation Excerpt :Generally, lumbar DS is an anatomic finding that develops as a result of inflammatory and remodeling FJ processes. Except for prostaglandins (e.g., prostaglandin E2 [PGE2]), inflammatory cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α), play a major role in the mediation of osteoarthritic changes in animals and humans [8–10]. These cytokines and matrix-degrading enzymes disturb chondrocyte metabolism, leading to cartilage degradation.
Scoping review to develop common data elements for lumbar spinal stenosis
2017, Spine Journal