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Factors related to Health-Related Quality of Life (HRQoL) among children with ADHD in Europe at entry into treatment

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Abstract

Objective

To describe the associations between a range of baseline factors (demographic, family and clinical) and parent-reported health-related quality of life (HRQoL) of children with ADHD taking part in the ADORE study.

Methods

HRQoL was rated using the Parent Report Form of the Child Health and Illness Profile-Child Edition (CHIP-CE). Forward-stepwise linear regression models were used to investigate associations with 26 independent variables. Separate models were fitted for each of the five CHIP-CE domains (Satisfaction, Comfort, Resilience, Risk Avoidance and Achievement) and two subdomains of Achievement (Academic Performance and Peer Relations).

Results

CHIP-CE domain mean scores were lower than community norms, especially for Risk Avoidance and Achievement, indicating a low level of HRQoL. Clinical factors significantly associated with a poorer HRQoL included ADHD symptoms (inattention, hyperactivity-impulsivity), conduct problems, peer relationship problems, having asthma, multiple other somatic symptoms and co-ordination problems. Family factors, such as having a parent with a health or mental health problem possibly caused by the child's illness, child not living with both parents and maternal smoking during pregnancy were also associated with a worse HRQoL in some CHIP-CE domains/subdomains.

Conclusions

Numerous factors independently impact on the HRQoL of children with ADHD.

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Abbreviations

ADHD:

Attention-Deficit/Hyperactivity Disorder

ADORE:

Attention-deficit/hyperactivity Disorder Observational Research in Europe

ADHD-RS:

ADHD Rating Scale

CD:

Conduct Disorder

CGAS:

Children's Global Assessment Scale

CGI-S:

Clinical Global Impression-Severity scale

CHIP-CE:

Child Health and Illness Profile – Child Edition

HRQoL:

Health-Related Quality of Life

ODD:

Oppositional Defiant Disorder

PRF:

Parent Report Form

SDQ:

Strengths and Difficulties Questionnaire

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Authors and Affiliations

  1. Johns Hopkins Bloomberg School of Public Health, 692 Hampton House, 624 North Broadway, Baltimore, MD 21205, USA

    Anne W. Riley PhD

  2. Landeskrankenhaus Klagenfurt, Dept. of Child and Adolescent Neuropsychiatry, Klagenfurt, Austria

    Georg Spiel

  3. Section of Psychiatry, Division of Pathology and Neuroscience, University of Dundee, Dundee, Scotland, UK

    David Coghill

  4. Dept. of Child and Adolescent Psychiatry, University of Cologne, Cologne, Germany

    Manfred Döpfner

  5. INSERM U669, Université Paris-Sud, Paris, France

    Bruno Falissard

  6. Eli Lilly and Company, Lilly Research Centre, Windlesham, Surrey, UK

    Maria J. Lorenzo

  7. Dept. of Child and Adolescent Psychiatry, University of Bern, Bern, Switzerland

    Ulrich Preuss

Authors
  1. Anne W. Riley PhD
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  2. Georg Spiel
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  3. David Coghill
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  4. Manfred Döpfner
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  5. Bruno Falissard
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  6. Maria J. Lorenzo
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  7. Ulrich Preuss
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  8. Stephen J Ralston**
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Consortia

ADORE Study Group*

Corresponding author

Correspondence to Anne W. Riley PhD.

Additional information

* Members of the ADORE Study Group G Baldursson, D Coghill, P Curatolo, S Dalsgaard, M Döpfner, B Falissard, A Hervas, MF Le Heuzey, TS Nøvik, RR Pereira, U Preuss, S Ralston, P Rasmussen, AW Riley, A Rothenberger, G Spiel, HC Steinhausen, L Vlasveld

**Employed by Eli Lilly and Company at the time the research was performed

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Riley, A.W., Spiel, G., Coghill, D. et al. Factors related to Health-Related Quality of Life (HRQoL) among children with ADHD in Europe at entry into treatment. Eur Child Adolesc Psychiatry 15 (Suppl 1), i38–i45 (2006). https://doi.org/10.1007/s00787-006-1006-9

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  • DOI: https://doi.org/10.1007/s00787-006-1006-9

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